Why not use phentolamine for high blood pressure?

Too big.

The cost of the drug is large, the finished product is high, and it is not suitable for long-term oral administration.

Phentolamine mesylate is known under the brand name "Viagra", which has a similar effect to Viagra, and I don't think it is suitable for male patients.

We still have so many effective, high-quality, and inexpensive antihypertensive drugs, why should we use them.

Phentolamine Other names: Pyrolamine Pyramitazoline Mesylate Fitumin Mesylate Risbutine Rychitin Rychitin.

Main ingredient: chlortaminezoline.

Properties: injection, tablet.

Indications: It is used for vasospasmodic diseases, such as acral artery spasm (i.e., Raynaud's disease), cyanosis of the hands and feet, etc., diagnostic tests for infectious toxic shock and pheochromocytoma, etc., and is also effective for premature ventricular contractions.

Usage and Dosage: 1Treatment of vasospasmodic diseases, intramuscular injection or intravenous injection, 5mg each time, 1 2 times a day.

2.Anti-shock: intravenous infusion in doses per minute.

3.Premature ventricular contractions: 50 mg orally 4 times a day for the first 2 days, if ineffective, increase the dose to 75 mg each time 4 times a day for the next 2 days.

If it is still ineffective, it can be increased to 400 mg a day; If it is no longer effective, it should be deactivated. Regardless of the dose, once effective, continue to take that dose for 7 days. 4.

Diagnosis of pheochromocytoma: 5 mg intravenously, blood pressure is measured every 30 seconds after injection, and it can be measured continuously for 10 minutes.

Adverse reactions and attention: Adverse reactions include orthostatic hypotension, reflex tachycardia, nasal congestion, itching, nausea, vomiting, etc.

Specification: Injection: 10mg (1ml) per vial. Tablets: 25 mg per tablet.

Manufacturer:--

Whether it is a medical insurance drug: medical insurance.

Over-the-counter or not: Prescription.

Other: 1It is contraindicated in patients with hypotension, severe arteriosclerosis, organic damage of the heart, and decreased renal function. 2.Do not be compatible with iron. 3.Keep away from light and moisture, and store in a dry and cool place.

In the end, *** is too big!

Phentolamine is a non-selective receptor blocker that blocks both 1 and 2 receptors. Phentolamine has the effect of blocking vascular smooth muscle 1 receptors and directly dilating blood vessels, reducing peripheral resistance and blood pressure. In addition, phentolamine can also excite the heart, increase myocardial contractility, increase heart rate, and increase cardiac output (which is not good for high blood pressure).

This excitatory effect is partly due to vasodilation, blood pressure reduction, and reflexive excitation of sympathetic nerves, and partly due to blocking the postsynaptic membrane 2 receptors at nerve endings, thereby promoting the release of norepinephrine and stimulating cardiac 1 receptors. That is to say, because phentolamine can block 2 receptors, a series of heart-stimulating consequences produce an increase in blood pressure, so it can only be temporarily used for hypertension caused by an overdose of sympathomimetic amines such as epinephrine, and cannot be used for long-term treatment of essential hypertension**. This is different from prazosin, which only blocks receptor 1 but not receptor 2, so it does not have the effect of stimulating the heart.

Hmm, the contradiction is so... I think a lot of things in pharmacology are based on the strength of the effect, for example, I still don't understand why propranolol lowers blood pressure, although it blocks B1, but also blocks B2... Later, I thought that people have clinically verified that it can lower blood pressure, so it can only be said that its pressurizing effect is not as good as that of lowering blood pressure, so it is lowered, if you want to say that it can't lower blood pressure, then A1 is also blocked, and it can't be said... So, it should be a superposition of effects.

However, it's still just a personal opinion, and if it's not right, I'm bothered to inform you...

Phentolamine can also block 2 receptors, and the effect of excitating the heart increases blood pressure, which can only be used temporarily for hypertension caused by sympathetic drug overdose, and cannot be used for long-term treatment of essential hypertension**.

Phentolamine acts non-selectively on receptors, blocks receptor 1 and directly dilates blood vessels, lowers blood pressure, reflexively strengthens myocardial contractility, and accelerates heart rate. Due to the blockade of 2 receptors, promote the release of nerve endings NA, excite the heart, and when used for high blood pressure, blood pressure can drop significantly and heart rate increases, and even arrhythmia.

Phentolamine is preferred for hypertension due to pheochromocytoma.

Hello, phentolamine can be used for high blood pressure, but due to its strong antihypertensive effect and rapid, it is only suitable for short-term intravenous medication in hypertensive emergencies. And it needs to be done under supervision.

Phentolamine is generally not used for high blood pressure, but it is only effective in temporarily lowering blood pressure and may promote higher blood pressure in the long term.

All kinds of antihypertensive drugs are gradually upgraded and replaced products. The drug is more potent and has new effects such as protecting the function of internal organs.

It's not bad for money, and it's good medicine directly.