What are the types of myasthenia gravis?

Type: ocular mg. Only the levator palpebrae palpebrae and extraocular muscles are affected, accounting for about 20 to 30%.

Type A: mild generalized MG. Mild weakness of limb muscles is the main manifestation, good response to drugs**, no respiratory muscle paralysis, accounting for about 30%.

Type B: Moderate generalized mg. Severe limb weakness, inability to take care of oneself, poor response to drugs**, but no dyspnea, accounting for about 25%.

Type: acute fulminate mg. Acute onset, rapid onset of severe muscle weakness symptoms and dyspnea within half a year, poor drug response, often combined with thymoma, high mortality rate, accounting for about 15%.

Type: Late severe mg. The clinical symptoms are similar to those of type I, but the course of the disease is longer, mostly more than 2 years, and it is formed by the gradual progression of type I or type II, accounting for about 10%.

Myasthenia gravis is a neurological disease, and the main symptoms are roughly mild and severe, with insidious onset, fluctuating throughout the course of the disease, alternating between remission and **, which should be divided into five situations:

1. Ocular muscle type.

2. A mild generalized type.

3. B moderate generalized type.

4. Acute severe type.

5. Delayed severe type.

6. Amyotrophic type.

Myasthenia gravis is divided into adult, child, and juvenile myasthenia gravis.

Adult myasthenia gravis is divided into five types according to the extent of skeletal muscle involvement and the severity of the condition: First, the ophthalmo-simple type. Lesions are always confined to the extraocular muscles and manifest as ptosis and diplopia.

Second, mild generalization. The disease progresses slowly and mildly, and no crisis occurs. Third, moderately generalized.

Severe muscle weakness with bulbar muscle involvement, but no crisis presents, and drug treatment is suboptimal. Fourth, the acute progressive type. Onset is acute, often progressing to bulbar and respiratory muscles within weeks of the first symptoms, with myasthenic gravis crisis, requiring tracheostomy, and high mortality.

Fifth, late-onset generalized muscle weakness. Sixth, those who have obvious manifestations of amyotrophy earlier. Pediatric myasthenia gravis is further divided into neonatal and congenital myasthenia gravis.

Eye muscle weakness Generalized muscle weakness.

Myasthenia gravis can be roughly divided into four types according to the internationally accepted Osseman classification:

type, a simple ocular muscle type, only the ocular muscle is affected.

type, which is also generally called mild generalized type. Progression is slow, crisis usually does not occur, ophthalmomuscle involvement may be combined, and drug sensitivity is also relatively high; IIB type, which is the moderately generalized type. Skeletal and bulbar muscles are severely affected, but there is no crisis and drug sensitivity is suboptimal.

type, also called severe aggressive type. Symptoms are critical, progress rapidly, and can peak over weeks or months. There is a possibility of respiratory crisis, the drug efficacy is relatively poor, the incidence of thymoma is relatively high, and the mortality rate is relatively high.

Types, also known as delayed-onset severe types, have the same symptoms as type III. It can develop from the above type I to type IIA, type IIB, and then progress to type IV over a period of several years.

Myasthenia gravis begins with muscle fatigue and can affect all muscles of the body, but it is often focused and predominantly localized.

Myasthenia gravis can be divided into four types depending on the severity of the disease.

1.The type is ocular and only the eye is affected.

2.The type is generalized, without the occurrence of a crisis, and can be divided into different subtypes depending on whether it is accompanied by significant bulbar paralysis.

3.The type is acutely progressive, meaning that the bulbar muscle can develop within months of the first symptoms.

4.The type is a late-onset type that develops from the first three types, often more than two years after the onset of the first symptoms.

Myasthenia gravis is mainly classified by Osserrman, which can generally be divided into five types.

The first type is the ophthalmosis type, which is also type I.

The second type is type II, which includes type A and type B, with type A being mildly generalized and type B being moderately generalized. Type A mainly involves the autologous body, causing autologous weakness.

The moderate generalized form of muscle weakness is relatively widespread and includes conditions such as tight muscles, as well as muscle handling of the ball, i.e., problems with chewing and swallowing, which is type IIB.

The third type is type III, type III will involve respiratory muscles, causing breathing disorders, generally refers to the onset of myasthenia gravis to the occurrence of respiratory dysfunction, respiratory failure, myasthenic crisis within half a year.

If respiratory muscle involvement occurs more than half a year later, it is considered to be the fourth type, i.e., type IV.

The fifth type is the type, that is, patients with myasthenia gravis have symptoms of muscle atrophy in addition to weakness symptoms, which is relatively rare.

Myasthenia gravis can be divided into 5 types. Ophthalmosis type, systemic type, acute severe type, delayed severe type, amyotrophic type. In addition, myasthenia gravis in children can be divided into three types, neonatal type, congenital myasthenia gravis, and circular myasthenia gravis.

Most myasthenia gravis will gradually worsen within two years, and eventually affect normal breathing and swallowing function, and lose the ability to take care of oneself. A small number of myasthenia gravis is an acute attack, which will cause short-term difficulty swallowing, difficulty breathing, and inability to take care of themselves.

Myasthenia gravis is generally divided into the following types:

First, bulbar type myasthenia gravis, which is characterized by weakness of the muscles in the face, and a low voice when speaking, which makes it easy to feel tired.

Second, the generalized type, which is mainly manifested as muscle weakness of the whole body, feeling weaker and unable to walk in severe cases.

Thirdly, the spinal cord type of muscle weakness, which manifests as weakness in the limbs, and the symptoms will be more obvious when walking and climbing stairs.

Fourth, the more common eye muscle type muscle weakness, manifested by drooping eyelids and difficulty in lifting, requires a neostigmine test, and if the symptoms are cured, it can basically be diagnosed.

Myasthenia gravis is an acquired autoimmune disorder in which the neuromuscular junction is impaired in the postsynaptic membrane of the neuromuscular junction, where the number of acetylcholine receptors (ACHRs) is reduced. The clinical feature is that some or all of the skeletal muscle is highly susceptible to fatigue, and symptoms usually worsen with activity and are relieved by rest and anticholinesterase drugs**.

Adult myasthenia gravis:

Pure ocular type, 15-20%, lesions confined to extraocular muscles, manifested by ptosis and diplopia;

Mild generalized, accounting for 30%, mild disease, no crisis, drug** effective;

moderate generalized, 25%, severe muscle weakness with bulbar muscle involvement, but crisis presents, medications** are suboptimal;

Acute severe type, accounting for 15%, acute onset, severe ventilator weakness, need for tracheostomy, high mortality;

Late-onset generalized myasthenic type, which accounts for 10% of cases, has a high mortality rate;

Type V is less common in patients with significant manifestations of amyotrophy at an earlier stage.

Pediatric myasthenia gravis: about 10% of patients with myasthenia gravis in China, most cases are limited to extraocular muscle paralysis, bilateral eyelid ptosis can alternately, about 1 4 cases can be relieved spontaneously, and only a few cases involve systemic skeletal muscles.

1. Symptoms of spleen and stomach weakness.

2. Symptoms of liver and kidney yin deficiency.

Ophthalmosis type: lesions are confined to the extraocular muscles, and within 2 years of onset, 70% may progress to other sites.

Systemic type: It can be understood that all parts of the body that are involved except for the eye muscle type belong to the systemic type. The mild generalized form usually does not have difficulty chewing, swallowing, or dysarthria, and is able to take care of itself; Patients with moderate to higher systemic forms usually develop the symptoms described above, with bent muscles and reduced ability to perform daily living.

Acute severe disease: this group of patients has a very acute onset and rapid progression, involving the laryngeal and/or respiratory muscles within weeks or months of onset. Most patients are unable to take care of themselves.

Late-onset severe: this type of patient has an insidious onset, slow-progression, and usually progressively worsens over a period of 2 years, eventually affecting the respiratory muscles.

Amyotrophic state contraction: skeletal muscle atrophy and weakness can occur within six months of the onset of the disease.

In the early stages of myasthenia gravis, you often feel soreness in your eyes or limbs, blurred vision, and fatigue easily. Fatigue is worse in hot weather. As the disease progresses, skeletal muscles become significantly fatigued and weak, most notably characterized by muscle weakness, which worsens with exertion in the afternoon or evening and lessens after waking up or resting.

In later stages, it can even cause weakness or paralysis of the respiratory muscles, resulting in severe dyspnea. You should usually work and rest on time, don't stay up late, and combine work and rest. It is necessary to pay more attention to regulating the diet, we must not be too hungry or too full, we must be regular and modest, and at the same time, all kinds of nutrients must be appropriate, and we must not eat partially.

Myasthenia gravis is an autoimmune disease caused by dysfunction of transmission at the neuromuscular junction, which is clinically manifested by the corresponding skeletal muscle involvement, and patients have ptosis, eye movement disorders, diplopia, swallowing weakness, proximal limb weakness, and can also involve respiratory muscles, resulting in dyspnea. Patients with myasthenia gravis have symptoms that worsen with activity and are relieved with rest.

Myasthenia gravis is a neuromuscular junction disorder that can cause symptoms such as muscle weakness, fatigue, and difficulty breathing. Myasthenia gravis can be classified into a variety of types according to the classification criteria of the segment difference.

According to the time of onset, it can be divided into acute myasthenia gravis and chronic myasthenia gravis.

Acute myasthenia gravis is a severe myasthenic symptom that develops over a period of weeks or months, usually requiring hospitalization**.

Chronic myasthenia gravis refers to symptoms of muscle weakness that last more than a year, but most patients have less than a year of disease.

According to the clinical manifestations, it can be divided into generalized, ptosis, bulbar paralysis, limb girdle, retrobulbar optic neuritis and others.

The systemic form is the most common type and includes a variety of mild and moderate symptoms that can affect the muscles of the patient's body.

Ptosis is when drooping eyelids are the main symptom and the other symptoms are milder.

The bulbar paralysis type is when the respiratory muscles are affected, making it difficult to breathe.

Limb-girdle refers to muscle involvement of the extremities, while retrobulbar optic neuritis refers to optic nerve and ocular muscle involvement.

According to the mode of inheritance, it can be divided into sporadic and familial types.

The sporadic type refers to myasthenia gravis with no obvious genetic background, while the familial type refers to myasthenia gravis with a family history.

In addition to the above classification methods, it can also be classified according to other characteristics, such as anticholinesterase type and non-anticholinesterase type according to drug response, and simple type and compound type according to the course of the disease.

In short, there are many classification methods for myasthenia gravis, and each classification method has its own characteristics and scope of application. Understanding the different types of symptoms and characteristics can help doctors develop individualized plans to improve outcomes.