Effects and side effects of sulfasalazine pyridine 5

The anti-inflammatory effects of sulfasalazine are well known, and it was once a common drug for ulcerative colitis. It can inhibit the activity of thromboxane synthase and lipoxidase, and also has an inhibitory effect on the movement of white blood cells and the activity of proteases. In addition to anti-inflammatory effects, sulfasalazine can also significantly reduce interleukin 1 and L, as well as tumor necrosis factor (TNF) 1 and interleukin-6, which are closely related to the mechanism of rheumatoid arthritis.

It is also believed that sulfasalazine can affect the absorption and metabolism of folic acid, so it has a similar effect to MTX. The above results suggest that sulfasalazine does have an effect on the immune system.

The effective dose of sulfasalazine** for rheumatoid arthritis is at least daily. Generally, starting from three times a day, if there are no adverse reactions, add to the second week, three times a day, and the third week, three times a day, generally the maximum dose does not exceed daily. It is generally believed that the higher doses of this drug have a better effect.

Sulfasalazine** is usually longer, usually 2 years or more. It is recommended to start daily and increase weekly, gradually increasing to daily.

There are more sulfasalazine sulfasalazine, and within the first 2 to 3 months, the common ones have gastrointestinal and central nervous system symptoms, such as nausea, vomiting, diarrhea, depression, headache, etc. Although the toxicity of sulfasalazine to the hematopoietic system is rare, it can also cause neutropenia, thrombocytopenia, hemolytic anemia, etc. Others include rashes, pneumonia, male infertility, etc.

Hello, sulfasalazine enteric-coated tablets can be effectively used for ulcerative colitis, and can be used together with anti-ulcer drugs such as mesalazine enteric-coated tablets, and the effect will be faster.

Sulfasalazine tablets are irreplaceable drugs for ulcerative colitis, which should be stored in the dark and are forbidden for those who are allergic to sulfonamides, pregnant women, lactating women, and children under 2 years old. The main ingredient of sulfasalazine tablets is sulfasalazine, which is a sulfonamide antibacterial drug, which is decomposed into 5-aminosalicylic acid and sulfapyridine in the intestine, which has antibacterial, anti-inflammatory and immunosuppressive effects. It is mainly used for inflammatory bowel disease, ulcerative colitis and other diseases.

In the intestine, it is broken down by bacteria there into sulfapyridine and 5-aminosalicylic acid. Sulfapyridine has little effect on the intestinal flora, and its effect is mainly on the active 5-aminosalicylic acid, which can inhibit the synthesis of prostaglandins, thereby playing an anti-inflammatory effect.

Sulfasalazine.

English name sulfasalazine Chinese alias sulfasalazine, sulfasalazine acid azosulfadiazine, salicylic acid azosulfadiazine, salicylyl azazosulfadiazine.

Synonyms azulfidine, colo-pleon, gastropyrin, salazopyrin, salazopyrina, salazosulfapyridine, salicylazosulfapyridine, salicylazosulphapyridine, salisulf, sulphasalazine

Synonyms sulfasalazine, sulfazosulfapyridine salicylate, sulfazosulfapyridine salicylate, sulfazosulfapyridine salicylate, azulfidine, colo-pleon, gastropyrin, salazopyrin, salazopyrina, salazosulfapyridine, salicylazosulfapyridine, salicylazosulphapyridine、salisulf、sulphasalazine

Catalog:Western medicine.