Is sodium ferulate a traditional Chinese medicine or a Western medicine, the effect of sodium ferula

Sodium ferulate should theoretically belong to traditional Chinese medicine.

Sodium feruloate for injection.

Drug Name] Generic name: Sodium ferulate for injection.

English name: sodium ferulate for injection

The main ingredient in this product is sodium feruloate, and its chemical name is: 3-methoxy-4-hydroxycinnamate sodium salt dihydrate. Its structural formula is: Molecular formula: C10H9NaO4 2H2O Molecular weight:

Properties] This product is a light yellow loose block.

Pharmacology and toxicology] This product is a non-peptide endothelin receptor antagonist, which can antagonize endothelin-induced vasoconstriction, vasopressor and vascular smooth muscle cell proliferation, and reduce vascular endothelial damage; Increases the synthesis of NO, relaxes vascular smooth muscle; Inhibits platelet aggregation, anticoagulation, and improves hemorheological characteristics. This product can also inhibit the synthesis of cholesterol, reduce blood lipids, scavenge free radicals, and prevent lipid peroxidative damage; It affects complement, enhances immune function, and has certain analgesic and antispasmodic effects. Intravenous administration, the half lethal dose (LD50) of mice is.

Pharmacokinetics】 Intravenous administration, plasma protein binding rate, rat distribution half-life (t1 2) is 3 minutes, elimination half-life (t1 2) is, rapid distribution, can pass the blood-cerebrospinal fluid barrier, mainly through the kidney excretion, not easy to accumulate in the body.

Indications] It is used for atherosclerosis, coronary heart disease, cerebrovascular disease, glomerular disease, pulmonary hypertension, diabetic vascular disease, vasculitis and other vascular diseases, as well as leukopenia and thrombocytopenia, and can also be used for migraine and vascular headache.

Usage and dosage] Intravenous infusion. Once a day, once a day, after dissolving, add 100 500ml of glucose injection, normal saline or glucose sodium chloride injection intravenously. Intramuscular injection.

Once, 1 2 times a day, dissolve in 2 4ml of normal saline before use. A course of treatment is recommended for 10 days. 【Adverse reactions】Occasional allergic rash reaction, which disappears after stopping the drug.

Contraindications】 Those who are allergic to this product are prohibited.

Precautions] When the normal saline is dissolved, a little precipitation will not affect the use, and it can be shaken well.

Pregnant and lactating women] is not clear.

Drug interactions] are not well understood.

Specifications] (1) (2).

Storage] shading, sealed storage.

Packing: Vial, box of 6.

Validity] tentatively set at 2 years.

Sodium ferulate is a Western medicine. Traditional Chinese medicine such as angelica contains a large amount of ferulic acid.

Western. Sodium ferulate is a chemical agent, molecular formula: C10H9NaO4, chemical name: 3-methoxy-4-hydroxycinnamate sodium salt.

Molecular weight: It is the sodium salt of ferulic acid.

Ferulic acid, chemical name is 3-(4-hydroxy-3-methoxyphenyl)-2-acrylic acid.

or 4-hydroxy-3-methoxycinnamic acid or 3-methoxy-4-hydroxycinnamic acid; or caffeic acid-3-methyl ether.

Molecular Formula: C10H10O4

Molecular weight: sodium ferulate 1, appearance: white or off-white crystalline powder; Odorless and slightly astringent.

2. Solubility: soluble in water, slightly soluble in ethanol, insoluble in chloroform or ether.

3. Absorption coefficient: 1ml contains about 10 g of solution, and the absorbance is measured at 310nm wavelength according to spectrophotometry, which should be 690 732

As the saying goes, medicine is three parts poisonous, so no matter what the disease is, patients must understand the dosage of the drug, medication attention, adverse reactions, etc. before taking the drug.

1. Functional indications

1. For the adjunct of atherosclerosis, coronary heart disease, cerebrovascular disease and other diseases, sodium ferulate can be used.

2. Sodium ferulate can be used for the reduction of white blood cells and platelets in vascular diseases such as glomerular diseases, pulmonary hypertension, diabetic vascular diseases, vasculitis, etc.

3. If the patient suffers from migraine, vascular headache and other diseases, sodium ferulate can be used to reduce the patient's pain and achieve further purposes.

2. What is the efficacy?

Sodium ferulate tablets, in clinical application, are mainly used in cardiovascular diseases. This administration can effectively strengthen some vascular diseases, remove blockages and stasis in the blood vessels, and thus ** cardiovascular diseases. For example, for coronary heart disease, cerebrovascular disease, or arteriosclerosis and other problems, it has a very effective auxiliary effect.

Therefore, if someone in the family has a certain cardiovascular or vascular disease, you can carry this medicine, which can effectively relieve the pain of these diseases and treat them to a certain extent. In addition to this disease, sodium ferulate can also be used to treat some migraines and vascular headaches, which are also very significant, and for migraine patients, this medicine can take care of different types of patients.

3. Manual

The main ingredient of this product is sodium ferulate, the molecular formula is C10H10O4, and the molecular weight is.

Dosage form: tablets.

Shape: This product is a round white trillion color or off-white wide hole.

Indications: It is mainly used for the auxiliary treatment of vascular diseases such as atherosclerosis, coronary heart disease, cerebrovascular disease, glomerular disease, pulmonary hypertension, diabetic vascular disease, vasculitis, etc., and can also be used for migraine and vascular headache.

Specifications Chinese and Western medicines:

50mg tablets.

Dosage: Oral. For migraine, vascular headache, 50 100 mg once, 3 times a day. For coronary heart disease, cerebrovascular disease, vasculitis and thrombocytopenia, 20 100 mg at a time, 3 times a day.

【Adverse reactions】Occasional allergic rash reaction, which disappears after stopping the drug.

Contraindications】 Those who are allergic to this product are prohibited.

Notes:1When the properties of this product change, it is forbidden to use. 2.Keep out of reach of children.

Drug Interactions:

It is not clear.

Synonyms] sodium ferulate, ligustrazine.

Indications] It is mainly used for atherosclerosis, coronary heart disease, cerebrovascular disease, glomerular disease, pulmonary hypertension, diabetic vascular disease, vasculitis and other vascular diseases, and can also be used for migraine and vascular headache.

Afoetul: Afoetul is a unique medicinal herb in Xinjiang. Perennial once-fruiting herb, ferul is divided into two kinds: Xinjiang and round-stemmed afoetidae, belonging to the Apiaceae, perennial herbaceous plants.

Xinjiang Aferulum is 50-100 cm high, the whole plant is covered with white hairs, the roots are hypertrophied, cylindrical or spindle-shaped, sometimes branched, the epidermis is purple-black, smelly, and has small yellow flowers. Compared to it, the round-stemmed Aferul plant is twice as tall and the stem is erect. Only Xinjiang grows in China.

Sexual taste: bitter, bitter, warm. Return to the kidneys and stomach meridians.

Indications: dissipation, dispersion, insecticide. It is used for meat stagnation, blood stasis and blood congestion, abdominal lumps, and abdominal pain. Rational qi to reduce swelling

It has the effect of invigorating blood and reducing fatigue, expectorant and stimulating nerves.

Dosage: 1 more into pills and external plasters.

Caution: Do not use in pregnant women.

Selected from (Chinese Pharmacopoeia).

Condition analysis: Hello, sodium ferulate is mainly used for the auxiliary of vascular diseases such as atherosclerosis, coronary heart disease, cerebrovascular disease, glomerular disease, pulmonary hypertension, diabetic vascular disease, vasculitis, etc., and can also be used for migraine and vascular headache.

【Ingredients】Sodium ferulate. (Chemical name: 3-methoxy-4-hydroxycinnamic acid sodium salt dihydrate).

Molecular Formula: C10H9O4Na [Molecular Weight] [Cas No] 24276-84-4 [English Name] Sodium Ferulic

There is no shortage of effective new drugs for migraines. Its curative effect is fast, effective for mild, moderate and severe patients, and it is the most important treatment for migraine.

Dosage and usage] Oral: 2 tablets each time, 3 times a day, and 1 tablet can be added for severe cases.

Intramuscular injection: 100-200 mg each time, 1-2 times a day.

Intravenous infusion: 100-200 mg each time, once a day.

Precautions] This product has low toxicity, no obvious side reactions have been found, and the safety factor is large.

Specifications] Tablets. Capsules: 200mg capsules; Injection: 100mg vial.

Aferul, mainly produced in Xinjiang, is the resin of Xinjiang Aferulum tree, belongs to a unique traditional Chinese medicine in Tibetan medicine, has the effect of regulating qi and reducing swelling, invigorating blood and eliminating fatigue, and stimulating nerves, and is often used for meat stagnation, stasis, abdominal lumps, worm accumulation and abdominal pain.

Synonyms] sodium ferulate.

Ligustrum. Adaptation to annihilation].

Mainly used for: Atherosclerosis.

Coronary heart disease, cerebral vascular disease, glomerular disease

Pulmonary hypertension.

Diabetic vasculopathy,

Vasculitis nucleus.

and other vascular diseases**, can also be used.

Migraines. Vascular headache.

Target**.