What are the benefits of estering with succinate, such as artesunate, why should you choose estering

1. The purpose of preparing derivatives from drug esters is to increase the lipophilicity (oil-solubility) of the drug (for example, artesunate is an oil-soluble injection), which is also conducive to absorption; The second is to enhance the stability of the drug (e.g., artemisinin itself is unstable).

2. Why don't you choose other acids? And with succinic acid?

1) There are many organic acids that can be used for the preparation of derivatives into drug esters, not only succinic acid, but also lactic acid, malic acid, tartaric acid, citric acid, acetic acid, etc., most of them are best used in natural medicines, on the one hand, the safety is guaranteed, on the other hand, they themselves also have certain medicinal value.

2) Succinic acid, also known as succinic acid, was originally obtained by distilling amber. Succinic acid is an intermediate product in the process of glucose metabolism in the body. The functions of itself are:

a. Antibacterial effect; b. It has anticonvulsant effect in the center; c. Anti-ulcer effect; d. It can inhibit passive and active allergic reactions, and reduce the formation of 1GE antibodies in animal serum; e. Detoxification effect: succinic acid has obvious protective effect on mice in poisonous cobras; f. Antispasmodic, expectorant and diuretic effects. The above effects will not be contrary to the antimalarial effect of artemisinin, and it has high efficiency with artemisinin esterification, so artemisinin is mostly estered with succinate.

3) Succinic acid, fumaric acid, tartaric acid, adipic acid, malic acid, citric acid, etc. are also acidulants of food

The two are different, and succinate ester is good.

The main ingredient of artesunate is artesunate, although because of the poor solubility of artemisinin in water and oil, it is made of water-soluble artesunate, but in use, it should still use 5% sodium bicarbonate injection that can completely dissolve it, so that it is safer to use!

Outward bound training is a new training method, which is characterized by open, sharing and happy experiential training, which is a comprehensive refinement and comprehensive supplement to orthodox education. Because knowledge and skills are only tangible capital, while will and spirit are invisible forces. Therefore, the outward bound training is more of a psychological challenge, guiding the trainees to complete a series of smelting team and challenging the extreme activities in the natural scenery.

Let students discover potential or blind spots that they are not usually aware of.

Therefore, to put it bluntly, the most important purpose of enterprises to lead employees to participate in development is to motivate employees' enthusiasm for work, increase the cohesion between employees, and increase employees' sense of identity with the company, so as to better serve the company and bring benefits to the company.

Moreover, outward bound training is often carried out in scenic spots with beautiful mountains and rivers, which can also be used as an employee benefit, but it is higher than the simple tourist price.

Strengthen team cohesion and improve employee enthusiasm, so as to achieve a significant improvement in enterprise performance.

I won't tell you that after I went to Dongsheng Tuoxun, my whole outlook on life has changed.

Alternating current has the advantage of being easy to generate, transmit and use, which is why we use it extensively. For example, long-distance transmission can use transformers to increase the voltage and reduce the current in the transmission line to reduce losses and obtain economic transmission benefits. In the case of electricity use, the voltage can be reduced through the transformer to ensure the safety of electricity use.

In addition, compared with alternators, AC motors and DC motors, AC motors have the advantages of simple structure, low cost, safe and reliable work, convenient use and maintenance, etc., so AC is widely used in various sectors of the national economy.

The main advantage of alternating current is that transformers can be utilized, whereas transformers cannot be used for direct current. This has led to a wide range of applications for alternating current.

There are many other advantages as well.

With the advent of the knowledge economy and the information age, the relatively closed economic pattern has been broken between countries. Resources, technology, information, etc. have gradually become the wealth shared by the world, the economic ties of various countries and regions are getting closer and closer, and the division of labor and cooperation in product production is becoming more and more significant. The emergence of a large number of regional and global economic organizations of multinational corporations has made the economies of all countries in the world more interdependent, integrated with each other, and developed in the direction of economic globalization.

The main thing is to divide and conquer a complex computer network, and each layer implements the corresponding functions, which is easy to manage, and the implementation of standards.

This layer only exists in books, not in practice.

You read the specific ones in the book.

There are so many advantages, hehe! Let me tell you a few.

One: If a company has 500 machines, you are a network administrator, you can't set the IP address one by one, this is the first point of dynamic allocation, to avoid the heavy workload of manual configuration by users.

2: There will be no conflict of IP addresses, if it is a static IP address, the client will inevitably have the problem of IP address conflict in the process of manual configuration, but with the dynamic allocation of IP addresses, this situation will not occur, because it is assigned to use the IP address in the DHCP address pool.

Three: When the company's IP address segment changes, the client does not need to modify it one by one, only need to modify the address pool, which is the third advantage of dynamic acquisition, which is convenient for the unified change of IP address.

When there are thousands of machines in a network, you know why. And network cloning, diskless workstations and the like use DHCP

Automate management and reduce workload!