What to do with 1 bottle of beer drunk at 9 p.m. and cefaclor eaten at 2 a.m

No problem. One is that 1 bottle of beer is not much; the second is 5 hours, which is longer; The third is that this medicine does not emphasize the prohibition of alcohol. But no matter what medicine you take in the future, you need to be careful not to drink alcohol!

Precautions for this medicine (when it comes to milk, if you avoid alcohol, you should also be prompted):

1 This product has a cross-allergic reaction with penicillin or cephamycin, so people who are allergic to penicillin, penicillin derivatives, penicillamine and cephamycin should use with caution.

2. Patients with renal function and liver function impairment should use with caution.

3 Patients with a history of gastrointestinal diseases, especially ulcerative colitis, localized enteritis or antibiotic-associated colitis, should be used with caution.

4. Long-term use of this product can cause dysbiosis and cause secondary infection.

5 Interference with laboratory indicators: antiglobulin (Coombs) test may be positive; Copper sulfate urine glucose test may be false-positive, but glucosease test is not affected; serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and blood urea nitrogen may be elevated; Serum and urine creatinine values may be falsely elevated using the Jaffe reaction.

6 This product should be taken orally on an empty stomach because food can delay its absorption. Milk does not affect the absorption of this product.

7 The safety of medication in children and neonates has not been established.

Hello, taking cephalosporins must be forbidden to drink alcohol, please let your relatives around you observe your movements, call 120 as soon as something is wrong, eating cephalosporin and drinking alcohol is easy to be life-threatening, so, if there is any problem, take first aid measures immediately, after eating cephalosporin normally, you can only drink alcohol after 72 hours, so, remember not to experiment with life in the future, you will reduce the symptoms by drinking more water now!

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1.If you have a cold and fever, drinking alcohol will only accelerate the development of fever, so you can't drink alcohol if you have a cold and fever. The alcohol in alcohol excites the central nervous system, leading to an accelerated spread of the virus.

2.Alcohol is easy to reduce the efficacy of some medicines, and some drugs have a chemical reaction with alcohol to produce harmful substances to the body, and some antibiotics and alcohol reactions will also be life-threatening.

Suggestion: cold and fever, don't drink alcohol during the period of taking medicine, eat lightly during the ** period, breathe more fresh air, and exercise appropriately to enhance resistance! Wait until you are well and then drink, and drinking is not bad for a day or two.

Don't drink beer while taking cephalosporins!

Drinking alcohol after taking cephalosporin drugs can cause disulfiram-like reactions.

Disulfiram-like reaction can be explained by the normal alcohol metabolism pathway, alcohol, the chemical name is ethanol, after entering the body, it is first converted into acetaldehyde by the action of ethanol dehydrogenase in the liver, and then converted into acetic acid by the action of acetaldehyde dehydrogenase, and the acetic acid enters the citrate cycle, and finally converts into water and carbon dioxide for excretion. Two enzymes in the link play an important role in alcohol metabolism. The cephalosporin antibiotics, especially the methyl thiotetrazolium group (MTT) contained in the third-generation cephalosporin antimicrobial molecule, can inhibit the activity of acetaldehyde dehydrogenase, so that the acetaldehyde cannot be degraded, resulting in acetaldehyde poisoning, which is the so-called disulfiram-like reaction.

As a result, it can cause red face, red ears, fast heart rate, low blood pressure and other manifestations, and in severe cases, respiratory depression, myocardial infarction, acute heart failure, convulsions and death.

Remember to avoid alcohol while taking the medication.

Don't eat cephalosporin when you drink alcohol in the future! It's not a big problem that you don't eat right away.

Disulfiram like reaction refers to facial flushing, conjunctival hyperemia, blurred vision, violent pulsation of blood vessels in the head and neck or pulsatile headache, dizziness, nausea, vomiting, sweating, dry mouth, chest pain, myocardial infarction, acute heart failure, dyspnea, acute liver injury, convulsions and death if alcohol is consumed after taking the drug, and blood pressure may drop, heart rate acceleration (up to 120 min) and normal or partial changes in electrocardiogram (such as ST-T changes) may occur during physical examination.

Its severity is directly proportional to the dosage and amount of alcohol consumed, and is more severe in the elderly, children, cardiovascular and cerebrovascular diseases and people who are sensitive to ethanol, and this reaction generally occurs 15-30 minutes after medication and drinking.

2. Which drugs can cause disulfiram-like reactions?

1.Cefoperazone, cefoperazone, sulbactam, ceftriaxone, cefazolin (Pioneer), cefradine (Pioneer), cefmetazole, cefmetazole, cefminol, laoxycephalosporin, cefmethoxime, cefmendo, cephalexin (Pioneer), cefaclor, etc.

Among them, cefoperazone-induced disulfiram-like reactions were the most reported and the most sensitive. If a patient eats liquor chocolate, takes Huoxiang Zhengqi water, or even treats it with alcohol alone** after use, a disulfiram-like reaction will occur.

The common chemical structure of these cephalosporins is the presence of a methiotetrazolium (thiomethyltetrazole) substituent similar to the molecule of disulfiram at position 3 of the 7-aminocephalic acid (7-ACA) ring in its parent nucleus, which competes with the coenzyme for the active center of acetaldehyde dehydrogenase, which prevents the continued oxidation of acetaldehyde, leading to the accumulation of acetaldehyde, thereby causing a thiosulfide-like reaction.

Problem Analysis:

Cephalosporin antimicrobial drugs are broad-spectrum antibacterial drugs, which have strong antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, and are mainly used for upper respiratory tract infections, soft tissue infections, genitourinary tract infections or abdominal organ infections caused by sensitive bacteria.

Suggestions: Because some cephalosporins will affect the metabolism of alcohol, which may cause dizziness, chest tightness, palpitation and even hypotensive shock and other discomforts, it is best not to drink alcohol while taking the drug, but not all cephalosporins will affect alcohol metabolism, the more common is cefoperazone. It shouldn't be a problem if you don't have symptoms now, but you need to be careful not to drink alcohol while taking the medicine in the future.