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1. Most (98%) of doxazosin in plasma binds to proteins. Human plasma data in vitro showed that doxazosin had no effect on the protein binding of digoxin, warfarin, phenytoin, and indomethacin;
2. No adverse drug interactions were found between doxazosin and thiazide diuretics, nitrofuraniline, blockers, non-steroidal anti-inflammatory drugs, antibiotics, oral hypoglycemic drugs, uric aciduria or anticoagulants in clinical use.
Doxazosin mesylate extended-release tablets are white film-coated tablets. Controlled-release tablets have more stable plasma drug concentration parameters than ordinary tablets. The plasma drug concentration peaked 8-9 hours after taking the drug, and the peak concentration was about the same as the trough concentration level of the two dosage forms after 1 hour of the same dose of ordinary tablets.
The peak-to-valley concentration ratio of doxazosin controlled-release tablets was lower than that of ordinary tablets. At steady state, the relative bioavailability of 4 mg of doxazosin controlled-release tablets was 54%, and that of 8 mg was 59% compared to normal. There was no significant difference in pharmacokinetic parameters between older patients and younger patients.
Patients should not think that they are adding or subtracting the dosage of drugs, or adding other drugs together, and any combination of drugs should be carried out under the guidance of a doctor.
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These two medicines are preferably not taken together.
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Disease analysis: Doxazosin mesylate tablets are A-receptor blockers, which effectively block the contraction of bladder smooth muscle, reduce the overactivity of the bladder, and thus reduce the symptoms of frequent urination and urgency. Suggestions: It is recommended to continue to eat, follow the doctor's instructions, and do not just read the instructions.
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It's better to eat before going to bed this night, *** a little smaller.
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Doxazosin mesylate tablets are A-blockers, which effectively block the contraction of bladder smooth muscle, reduce the overactivity of the bladder, thereby reducing the symptoms of urinary frequency and urgency. It is usually used for prostate disease**, because men are more prone to problems with the prostate, and prostate problems generally affect urination. The key depends on whether you have urinary urgency and frequent urination symptoms, if you do not have frequent urination and urgency symptoms, you do not need to take doxazosin mesylate tablets.
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You can check the instructions, and if you don't trust it, you can go to another regular hospital for consultation.
If you need it urgently**, you can refer to the instructions and eat the minimum amount first.
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Do not cure this doctor prescribes this medicine. You can ** or directly ask why you are prescribed this medicine, and the doctor will interpret it, otherwise you can complain to him.
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When taking this sustained-release tablet, the tablet should be swallowed whole with sufficient water, and should not be chewed, broken or crushed, regardless of whether it is eaten or not The most common dose is 4mg once daily. The maximum dose used in clinical use abroad is 8mg once a day, and there is no clinical experience in China. Doxazosin can be used for patients with renal insufficiency and elderly patients; For patients with liver insufficiency, see [Precautions]. When taking this sustained-release tablet, the tablet should be swallowed whole with sufficient water, and should not be chewed, broken or crushed, regardless of whether it is eaten or not The most common dose is 4mg once daily.
The maximum dose used in clinical use abroad is 8mg once a day, and there is no clinical experience in China. Doxazosin can be used for patients with renal insufficiency and elderly patients; For patients with liver insufficiency, see [Precautions].
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The medication should be taken at night before going to bed to reduce symptoms, and it is important to monitor your blood pressure while taking the medication. If the reaction is still relatively large, you can go to my clinic again and use other early drugs with caution. Shanghai Changhai Hospital-Department of Urology-Chief Physician Wang Linhui View the original post 》Qingque.
Paclobutrazol is a plant hormone drug, mainly to control plant growth, but at the same time it is a bactericidal drug, if it is to be used on cabbage, it should be applied scientifically and appropriately, and it is best not to use it.
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