Penicillin allergic patients must not relinate cephalosporin 25

Patients with penicillin allergy are not necessarily immune to cephalosporin. Because penicillin and cephalosporin are not the same type of antibiotic. Penicillin is a penicillin class of antibiotics such as:

Ampicillin, oxazole penicillin, etc. are all penicillins. Cephalosporin is a cephalosporin antibiotic, such as: ceftriax 5, 4, ceftriaxone sodium, ceftazidime needle, etc.

Regarding the problem of your son's fever, if the water is not good for six days, you should check the cause, and you are not very clear here. The doctor won't just use cephalosporin, but with antivirals. Now there are many virus infections.

The medication is not clear, and we dare not talk nonsense. Check the blood picture to see what the cause is, and it's okay**.

After six days of cephalosporin, the fever still does not subside. This fever is too long.

The main reason is that the usual cold and fever are minor diseases, and cephalosporin should not be imported**, and as a result, in the long run, resistance to cephalosporin is produced. This cause is more likely, and you can change the usual antibiotics, except for penicillin.

It is recommended to go to a big hospital to find a familiar one for careful examination, because low-grade fever is often a precursor to major inflammation or cancer.

Usually over-medical, if the cold is not serious, you should not hang cephalosporin, try to drink water and pay attention to rest, and if you really can't take the right medicine.

Categories: Healthcare.

Problem description: The doctor prescribed me "cefuroxime ester capsules", I didn't look at it carefully, but when I went home, I carefully read the instructions and found that it said "cephalosporin antibiotics and penicillin drugs have cross-reactivity reports, so patients who are allergic to penicillins and have destroyed holes should be used with caution". I had not taken penicillin before, but I had a skin test of penicillin and had an allergic reaction. I want to ask, don't I mean that I can take this drug?

Analysis: The so-called cross-allergic reaction means that penicillin allergy but cephalocytic drugs are not necessarily allergic and general cephalophytic allergic reactions are very mild unless it is a person with a specific constitution, so people who are allergic to penicillin can also take cephalocytic drugs Add a sentence I am a young doctor who has been practicing medicine for seven years.

This is because the main allergic mechanisms are different. Penicillin allergy is because it opens the ring: from this to this:

After ring opening, penicillium thiazole is formed, which binds to protein polypeptides to produce penicillium thiazole protein, which is the main epitope; After ring opening, penicillium thiazole is formed, which is combined with protein polypeptides to form penicillium thiazole protein, which is the main antigenic determinant; The rings of cephalosporin are very stable, and the allergy is mainly due to the R1 side chain: to put it simply, the main cause of penicillin allergy is that the mouth is opened to eat the protein, so it dies!

To put it simply, the main reason for penicillin allergy is that you open your mouth and eat protein, so you die! Cephalosporin allergy is because the R1 side chain attracts bees and butterflies, so he dies! So if you are allergic to penicillin, you may not be allergic to cephalosporin, because cephalosporin will not open your mouth!!

However, there is also a secondary epitope, which is a mechanism of partial cross-allergies. <>

Cephalosporins and penicillins have cross-allergies, but they are not necessarily allergic, so in order to avoid the possibility of crossing, it is best to choose non-cross-crossing species. However, clinical medicine doctors have a great deal of autonomy and experience, and doctors often do not implement the principles written in the textbooks. So experience is something you have to accumulate rather than learn from books.

This is the truth.233 According to our teacher, the allergy to penicillin is mainly due to the problem of purification technology, and the allergy to impurities other than penicillin in penicillin preparations. Consideration may be given to avoiding cephalosporin as much as possible. Although, the chance of a true cross-allergic reaction leading to shock is around 5-10%.

But to be sure, doctors should avoid giving cephalosporin to patients with a history of anaphylactic shock. <>

There are no contraindications. It has no cross-allergic reaction with penicillin and cephalosporin antibiotics, and can be used for those who are allergic to penicillin. Adverse reactions to clindamycin:

Can cause gastrointestinal reactions: nausea, vomiting, loss of appetite, bloating, diarrhea. Rash, leukopenia.

Elevated aminotransferases. It can cause superinfection, pseudomembranous colitis. Dyspnea, swollen lips, swollen nasal passages, lacrimation, and allergic reactions may also occur.

It has been reported that the incidence of pseudomembranous enteritis caused by this product is the highest, which may exceed 2. About 10 people taking clindamycin** develop a rash, and others such as exudative erythema multiforme, reversible elevated serum aspartaminotransferase and serum glutamylaminotransferase, granulocytopenia, thrombocytopenia, and other allergic reactions may be seen occasionally. 1.

Local reactions: After intramuscular injection, pain, induration, and aseptic abscess may occasionally appear at the injection site. Long-term intravenous infusion should be noted for the appearance of phlebitis.

2.Gastrointestinal reactions: occasional nausea, vomiting, abdominal pain, and diarrhoea.

Pseudomembranous enteritis occurs in 1 to 2% of patients. 3.Allergic reactions:

A small number of patients may present with drug-induced rash and, occasionally, exfoliative dermatitis. 4.There is basically no toxic reaction to the hematopoietic system, and occasionally it can cause neutropenia, eosinophilia, thrombocytopenia, etc., which are generally mild and transient.

5.Transient alkaline phosphatase, mildly elevated serum aminotransferases, jaundice, and abnormal renal function may occur. 【Contraindications】 This product has cross-resistance with lincomycin and clindamycin, and it is forbidden for those with a history of allergy to clindamycin or lincomycin.

Philophiles and cephalosporins both belong to the -lactam class Clindamycin belongs to the lincomycin class Allergic to penicillin Not necessarily allergic to clindamycin However, before use, it is best to do a skin test in case you are also allergic to lincomycin However, lincomycin is relatively stable and not easy to produce allergies What are the adverse reactions you are referring to? ?

Penicillins and cephalosporins have a similar antimicrobial spectrum to clindamycins and are sensitive to gram-positive bacteria! Bacterial infections that are allergic to penicillin or cephalosporins, if you are sensitive to clindamycin, can switch to clindamycin!

Yes, my clindamycin is used as a substitute for penicillin cephalosporin allergy**...

Disease analysis: If there is a penicillin allergy, it is also necessary to perform a test when using ceflin-called antibiotics**.

Guidance: If there is no abnormality in the experiment of allergy with cephalosporin antibiotics, it can be used, and there will generally be no other effects.