Zhang Deli s dissertation report, Zhang Deli s academic achievements

Updated on amusement 2024-05-07
2 answers
  1. Anonymous users2024-02-09

    Two important landmark identification results have been obtained: (1) Jingke Dengzi No. 20040602: the first successful development and long-term wide application of safe and efficient mink enteritis virus cell culture inactivated vaccine; (2) General Post Assurance No. 2002121008:

    The first discovery and successful replication of malignant rhabdomyoma (MRT) in a model animal provides an opportunity to elucidate the mystery of its origin; From the perspective of chromosomal genetic variation, the occurrence and development of MRT were preliminarily clarified, and the histocytic origin of MRT was revealed from the perspective of comparative medicine. It solves the problem of oncogenic toxicology experiments of passage cells (CCL), and reveals the relationship between genetic variation rate and carcinogenicity (tumor).

    In the field of biological cycle breeding, the theory and technical system of the alternating biological cycle breeding effect of the advantages and disadvantages of virus cytogenetic evolution has been preliminarily established and has been applied in practice, which is related to the development of high-efficiency mink parvovirus vaccine, the technological innovation of recombinant plasmid transfection of vaccinia virus, the toxicological safety evaluation of cell lines, the establishment of the transformation phenomenon of heterogeneous tumor in vivo experiments and the preliminary revelation of the mystery of the origin of rhabdomyoids, which has extensive scientific guidance and practical significance.

    Important progress has been made in the new methods of gene identification and functional gene isolation: a method for discovering new human genes from the perspectives of computer software analysis, human intervention analysis and experimental biology has been established, and it has been proved to be an effective way to accelerate gene cloning and identification; The collaborators' research on the algorithm of new gene recognition and regulatory region** has significantly improved the accuracy of genes and promoters, and the initial cooperation has established an automated electronic cloning software for new human genes. More than 100 new human genes were cloned electronically, and 800 new human gene candidates were identified by computers, and some of the gene coding sequences have been confirmed and cited by random experiments, and several of the new cloned genes have shown obvious biological functional activity in animal experiments. It was found that there were various types of errors in the human gene pattern reference sequence (RefSeq) published by the NCBI Genome Annotation Project in the United States, which suggested that the NCBI RefSeq database should be used with caution.

    In the field of molecular virology and antisense genes, he is responsible for "antisense RNA blocking duck hepatitis B virus (DHBV) replication and polyzyme region (P region) gene expression", constructing and purifying several antisense and sense recombinant viruses targeting different fragments of genes in DHBV P region or core region (C region), which laid the foundation for the establishment of an experimental model of hepatitis B duck body. The exploratory research on the transfection technology of recombinant plasmid of vaccinia virus and the purification method of spot erosion of recombinant vaccinia virus have achieved good results, the former simplifies the gene transfection technology for the first time, and the latter greatly reduces the main experimental cost for the first time and has been cited and proved to be effective.

  2. Anonymous users2024-02-08

    1 Zhang Dehe. Infrared spectroscopic identification. See: Zhu Shannong and others. Anatomy of polymer materials. Beijing: Science Press, 1988, 25-35

    2 Chen Benming, trans. Zhang Dehe. Handbook of Analysis of Polymers and Plastics (J.)Obansky et al.).Beijing: Chemistry and Chemical Engineering Press. 1982

    3 Zhang Dehe, Chen Kang, Qian Renyuan. The molecular weight distribution of polycaprolactam was measured by the old brigade. Acta Chimica Sinica, 1955, 21:63

    4 Zhang Dehe, Qian Renyuan. The intrinsic viscosity is calculated from the viscosity of a solution at one concentration. Polymer Communications, 1957, 3:39

    6 Zhang Dehe, Liu Dengliang. Study on the structure of weathered fulvic acid in Turpan, Acta Chimica Sinica,1982,40:933; 40:1123

    7 Yu Xiaochun, Hou Gui, Zhang Dehe. Graft copolymerization modification of humic acid and styrene. J Appl Chem Reed,1989,6(1):36

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