Are there any headaches about the side effects of apatinib?

The phase III clinical study of apatinib showed that the proportion of headache, headache and dizziness symptoms in the experimental group and placebo group were and respectively, and there was no significant difference between the two. According to this study, headache has nothing to do with apatinib, that is, the probability of headache between the two groups of patients is similar to that of taking apatinib and eating ordinary vitamins or even pure corn flakes, and there is no statistical difference.

However, as with all drugs, targeted drugs have side effects, and apatinib has a common side effect of hypertension, which can cause headaches, and daily monitoring of blood pressure is recommended. In addition, disease progression and deterioration of nutritional status in patients with advanced cancer may cause these symptoms, and the presence of brain metastases should be ruled out.

It is recommended that patients consult with the attending physician to determine the cause of the headache, actively treat the primary cause of the headache, and use analgesics appropriately if the severe pain is unbearable.

The *** of apatinib has:

A little tired, tired, 9: a little puffy face. From the library, you can take a look at it, I hope it is useful.

1. Apatinib is the world's first small molecule anti-angiogenic targeted drug that has been proven safe and effective in advanced gastric cancer, and it is also a monotherapy that significantly prolongs survival after the failure of standard chemotherapy for advanced gastric cancer.

2. At the same time, the drug is the only oral preparation among the targeted drugs for gastric cancer, which can effectively improve the compliance of patients and significantly reduce the cost. Highly selectively competes for ATP-binding sites of VEGFR-2 in cells, blocks downstream signal transduction, and inhibits neoangiogenesis in tumor tissues.

On December 13, China's self-developed small molecule targeted drug "Apatinib mesylate Tablets" for advanced gastric cancer was approved by the State Food and Drug Administration.

Its chemical name is N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridylmethyl)amino]-3-pyridincarboxamide, and its drug is the world's first small molecule anti-angiogenic targeted drug that has been proven to be safe and effective after the failure of standard chemotherapy for advanced gastric cancer, and at the same time, apatinib is also the only oral preparation among the targeted drugs for advanced gastric cancer, which can significantly prolong the survival time of patients with advanced gastric cancer and effectively improve the compliance of patients. According to the news of the National Health and Family Planning Commission on the 13th, China's self-developed small molecule targeted drug "Apatinib Mesylate Tablets" for advanced gastric cancer has been approved for marketing by the State Food and Drug Administration, which is another major breakthrough in the field of tumors with the support of China's major national major new drug creation science and technology major projects.

OverviewApatinib is the world's first small molecule anti-angiogenic targeted drug that has been proven safe and effective in advanced gastric cancer, and it is also the single agent with the best efficacy after the failure of standardization** in advanced gastric cancer. In addition, apatinib is also the only oral drug among the targeted drugs for gastric cancer, which will greatly improve the rate of patients. In June 2014, the clinical study of the drug was selected by the American Society of Clinical Oncology (ASCO) as a conference report, which was the first time that China's innovative drug research was presented at a top global academic conference, and the first time it was selected as an excellent research at the annual meeting.

On December 13, 2014, Jiangsu Hengrui Pharmaceutical Co., Ltd. announced that the new drug approved by the State Food and Drug Administration for advanced gastric cancer - Apatinib (apatinib) was officially launched in China. Etan, that is, apatinib mesylate tablets, is the world's first oral small molecule anti-angiogenic targeted drug that has been proven to be safe and effective after the failure of standard chemotherapy for advanced gastric cancer, which can significantly prolong the overall survival of patients with advanced gastric cancer, bringing new hope to patients with advanced gastric cancer.

Introduction Apatinib is a molecularly targeted anti-tumor drug, a new class of drugs independently developed by Jiangsu Hengrui Pharmaceutical Co., Ltd., and a small molecule vascular endothelial growth factor tyrosine kinase inhibitor with independent intellectual property rights.

As the saying goes, "medicine is poisonous", it will bring more or less *** while reducing the pain of patients and alleviating the pain of patients. Apatinib, as an anti-angiogenic drug, can have adverse effects while bringing efficacy.

We need to know that apatinib is generally mild and predictable, manageable, and positively correlated with efficacy. If you hear that the drug has *** and do not follow the doctor's instructions, it will lead to poor effect and unsatisfactory prognosis. Therefore, you should communicate more with your doctor, use drugs scientifically under the guidance of your doctor, and at the same time conduct necessary examinations regularly and develop good living habits in your daily life, without worrying too much about apatinib***.

Haizhou Chen Guangrui won the top prize, and was hit by Yin Wenjiao, the daughter of Prime Minister Yin Kaishan, and became a good son-in-law, but was murdered by thieves Liu Hong and Li Biao on the way to Jiangzhou. Yin Wenjiao gave birth to a son, threw into the river, was rescued by the monk Faming of Jinshan Temple, named Jiangliu, and was ordained at the age of eighteen. His legal name is Xuanzang.

Later, Xuanzang's mother and son met. avenged the past. [3]

Although apatinib is a very effective and relatively safe anti-cancer drug cavity fissure, no matter how good the drug is, it will be accompanied by some possible problems. Apatinib is an anti-angiogenic drug that inhibits angiogenesis and cuts off the oxygen and nutrient supply to tumors, thereby inhibiting tumor growth and metastasis. Continuous angiogenesis is one of the important features of tumor cells.

Therefore, when the anti-angiogenic drug takes effect, there may be some other effects, such as the more common hand-foot ** reaction, which may damage the blood vessels and vascular repair when blocking the angiogenesis pathway. Another possibility is to prevent the production of NO on arterial endothelial cells, triggering systemic vasoconstriction, thereby causing an increase in blood pressure. However, there are research data that show that these *** are often a manifestation of the effectiveness of the drug, and the patients who have *** may have better efficacy and longer survival.

Yes, every medicine