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Professor Jin Yongjian of cerebrovascular disease reminded that arterial stenosis or occlusion can easily lead to cerebral ischemia, and the smoky blood vessels at the base of the skull are very fragile and easy to rupture and cause cerebral hemorrhage, so the symptoms of moyamoya disease mainly include ischemic symptoms and hemorrhagic symptoms. Ischemic symptoms such as headache, dizziness, nausea, vomiting, some people may have varying degrees of consciousness impairment, mental retardation, sensory loss, dysphonia, aphasia, migraine, headache, cranial nerve damage, etc., severe ischemia can be seen acute hemiplegia; Hemorrhagic symptoms mainly refer to intracranial hemorrhage, and 12% to 14% may have subarachnoid hemorrhage, intraventricular hemorrhage or intracerebral hemorrhage, and some may even reverse.
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Moyamoya disease is a rare cerebrovascular disease, but the incidence and detection rate of moyamoya disease in China have increased in recent years. There are many patients who ask what causes moyamoya disease. This is a relatively complex issue, and the current academic community is not very clear about the cause of moyamoya disease.
Some scholars believe that moyamoya disease may be genetic, but there is no definitive evidence to prove the hereditary nature of moyamoya disease, except that some statistics show that moyamoya disease has a certain familial nature and the incidence is higher among siblings and relatives of moyamoya disease patients. Some scholars believe that this acquired disease may be related to vascular infections and immune diseases.
Although there is no consensus in the academic community about what causes smoke, everyone is unanimous about the first cause of smoke disease. It is generally accepted in the medical community that moyamoya disease is conservative** and that surgery should be performed as soon as possible once the diagnosis is confirmed**. Professor Jin Yongjian, a well-known neurosurgeon and director of the Department of Cerebrovascular Neurosurgery of the Aviation General Hospital, also has this view, and has carried out a lot of fruitful work.
In recent years, Professor Jin has carried out more than 1,000 cases of combined vascular bypass surgery, and has achieved very good clinical results.
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Professor Jin Yongjian reminded that arterial stenosis or occlusion can easily lead to cerebral defection and bleeding, and smoky blood vessels at the base of the skull are very fragile and easy to rupture and cause cerebral hemorrhage, so the symptoms of moyamoya disease mainly include ischemic symptoms and hemorrhagic symptoms. Ischemic symptoms such as headache, dizziness, nausea, vomiting, some people may have varying degrees of consciousness impairment, mental retardation, sensory loss, dysphonia, aphasia, migraine, headache, cranial nerve damage, etc., severe ischemia can be seen acute hemiplegia; Hemorrhagic symptoms mainly refer to intracranial hemorrhage, and 12% to 14% may have subarachnoid hemorrhage, intraventricular hemorrhage or intracerebral hemorrhage, and some may even reverse.
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Moyamoya disease, also known as spontaneous basilar artery annular occlusion or abnormal vascular network disease at the base of the brain, is an unknown chronic cerebrovascular disease, characterized by the slow thickening of the arterial intima at the end of the internal carotid artery (ICA), the anterior cerebral artery (ACA) and the beginning of the middle cerebral artery (MCA), the gradual narrowing of the arterial lumen to the point of occlusion, and the compensatory dilation of the perforator artery at the base of the brain.
Narrowing or occlusion of the initial intracranial segment of the internal carotid artery results in the appearance of abnormal vascular networks at the base of the brain, which are used on cerebral angiography.
It resembles "smoke", so the disease is named moyamoya disease.
Moyamoya disease by magnetic resonance imaging.
MRI) Magnetic Resonance Angiography (MRA) and Digital Subtraction Angiography (DSA) can determine the degree of progression of the disease and the corresponding stage.
The harm of moyamoya disease is extremely great, and in severe cases, it will be life-threatening, and the harm is mainly reflected in two aspects: cerebral blood loss and hemorrhage, and the symptoms of cerebral ischemia are mainly transient ischemic attack.
TIA), cerebral infarction.
Hemiplegia. Epilepsy.
Wait; Symptoms associated with bleeding include intracerebral hemorrhage.
Headache, vomiting, impaired consciousness.
Wait; Moyamoya disease** focuses on improving blood circulation at the lesion and preventing cerebral blood flow from being blocked and squeezing the upstream blood vessel wall, causing cerebral hemorrhage; It is also necessary to prevent subsequent blood vessels from experiencing ischemic symptoms due to insufficient blood supply, such as brain cell death, cerebral infarction, etc., after the cerebral blood flow is blocked.
Moyamoya disease has not yet been clarified, so it cannot be targeted for **, and the patient cannot be completely cured. At present, it can only be done according to the patient's symptoms** to control the progression of the disease.
The effect of the disease is related to the age of the patient and the symptoms that appeared before; At present, the efficacy of various surgical methods has been reported differently and is highly controversial.
The survival cycle of moyamoya disease patients is related to various factors such as symptom severity, vascular lesions, surgical methods, and postoperative care. Timely and effective surgery** can significantly improve the quality of life and prolong the survival of patients.
Daily prevention: Maintain a good attitude and be emotionally stable. Control blood pressure, avoid strenuous exercise, extreme exercise, avoid flying as much as possible, and have regular check-ups.
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1. Recurrent hemiplegia.
Patients with moyamoya disease may have recurrent hemiplegia in the early stage, hemiplegia caused by moyamoya disease will be intermittent and self-healing, after the occurrence of hemiplegia, after a period of time, there will be recovery is not like the hemiplegia caused by brain damage is permanent, irreversible, and hemiplegia will recur, and it will appear again after a period of time. Once the patient has this recurrent deviation symptom, it must be suspicious of moyamoya syndrome.
2. Headache. Headache is one of the early symptoms of moyamoya syndrome, and the patient's headache is also episodic, most headaches will appear migraine, the pain may be more intense, or it may be mild, which depends on the degree of the patient's condition.
3. Vision problems.
Patients with moyamoya syndrome may have symptoms of vision problems in the early stages, and patients may have blurred vision and a lack of vision during the disease. Therefore, if a patient has vision problems or career difficulties, it is important to see if it is caused by moyamoya syndrome, rather than simply from the eye disease.
Fourth, intellectual problems.
Patients with moyamoya syndrome may also have intellectual problems, many patients with moyamoya syndrome will have mental decline and memory loss during the early onset of symptoms, and many other problems related to intelligence, if there is a sudden decline in intelligence under normal intelligence conditions, it is necessary to be vigilant that it is moyamoya syndrome.
5. Epilepsy. Epilepsy is a symptom of most patients with moyamoya syndrome, and patients with moyamoya syndrome may experience some involuntary movement disorders, which can be regarded as mild epilepsy. In patients with early moyamoya disease, seizures may be persistent, but most cases may be intermittent and frequent.
During the examination, you will see that the EEG is a seizure-like discharge.
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Moyamoya disease is a rare cerebrovascular disease, mainly due to narrowing or occlusion of cerebral arteries, which leads to the formation of a compensatory small vascular network of abnormal skull bases, which is smoky during cerebral angiography, hence the name moyamoya disease.
Moyamoya disease mostly starts with headache, dizziness, nausea and vomiting, and some patients may have varying degrees of consciousness impairment, mental retardation, sensory loss, dysphonia, etc., 12% 14% of patients may have subarachnoid hemorrhage, intraventricular hemorrhage or intracerebral hemorrhage, and even some patients will have reverse.
At present, it is generally accepted in the medical community that there is no benefit in the conservative internal medicine of moyamoya disease**, and surgery should be performed as soon as possible once the diagnosis is clear. At present, the traditional surgical methods for moyamoya disease in China, direct bypass surgery and patch surgery, have their defects and limitations, such as the limitation of the improvement range of direct bypass on blood supply, such as the slow onset time of patching.
Professor Jin Yongjian, a doctor studying in Japan, used the method of combined vascular bypass surgery**Moyamoya disease.
Combined vascular bypass surgery is a dual operation of direct bypass + patching, direct bypass immediately improves the blood supply to the brain and prevents recurrence in the short term, and at the same time, multi-factor application is applied to the brain surface to induce neovascularization, expand the scope of blood supply improvement, and re-establish a perfect blood bypass, which has absolute benefits for improving the blood supply to patients with moyamoya disease.
Professor Jin Yongjian has completed more than 1,000 cases of moyamoya disease combined with vascular bypass surgery, and all of them have achieved good recovery results. Recently, Professor Jin Yongjian also successfully completed the first combined vascular bypass surgery for the youngest child (2 years old) with moyamoya disease in China**, which caused great repercussions in the domestic medical community.
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The disease of moyamoya disease is relatively complex and is being explored at home and abroad. Scholars summarize the reasons as follows: 1
It is related to congenital factors, including genetic factors and autoimmune factors; 2.Associated with acquired factors, including environmental factors, infections, or autoimmune diseases. In most cases, the prognosis depends on the natural progression of the disease, i.e., the age of onset, the primary onset**, the severity of the disease, and the degree of brain damage.
**Timely and appropriate also has a certain impact on prognosis.
The principle of moyamoya disease is early stage, and the early stage should mainly be treated with drugs. In the early stage, it is mainly aimed at moyamoya disease, and the main method of moyamoya disease is drugs, and the drugs for moyamoya disease refer to the main symptoms and causes of moyamoya disease. Moyamoya disease is generally controlled, and for early moyamoya disease, the following measures are used
Medications**: Medications** generally do not require the use of special medications. Generally, the main thing is to control or delay the progression of the disease, and some drugs can be taken to control the progression of the disease, which can generally be controlled after about 3-6 months.
Cerebrospinal fluid cytology: After the condition is controlled, you can consider selecting appropriate drugs for **, and the most commonly used drugs are neurobiofeedback inhibitors, such as lidocaine, sodium valproate, etc. Lidocaine has anticonvulsant effects and is beneficial for delaying the progression of intracranial lesions; Sodium valproate can promote the repair of damage to the brainstem and medulla oblongata, or promote the repair of damage to the brainstem and medulla; Lidocaine can inhibit viral proteins and inhibit viral replication, and promote the repair of nerve cells.
For moyamoya disease**, electroencephalogram (EEG) is a very important test that can help determine the state of the patient's nervous system, and it will also be of great help to epilepsy**. EEG changes are difficult to detect in the early stages, and once EEG abnormalities are found, they should be diagnosed and ** promptly.
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It may be because of regular smoking, and it is also a genetic factor, and eating some foods that are not easy to digest, and the immunity is relatively low, so it can lead to moyamoya disease.
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Moyamoya disease is related to genetic and environmental factors, and people with moyamoya disease are more likely to get moyamoya disease, and it may also be caused by facial infection.
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At present, the cause of moyamoya disease is not clear, and it is mainly related to the environment. People who live in polluted environments for a long time are more likely to get sick. The second is related to genetic inheritance.
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The specific ** of moyamoya disease is still unclear, and if we know for sure**, we call it moyamoya syndrome.
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Hello, moyamoya disease is mainly caused by congenital cerebrovascular malformation, which belongs to the congenital malformation of cerebral vascular development.
It is suggested that we are caused by cerebrovascular malformation, which was discovered through cerebral hemorrhage. **Mainly through surgery**.
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There are two types of moyamoya disease: cerebral ischemia and cerebral hemorrhage.
Ischemic moyamoya disease: children usually present with symptoms of an ischemic attack. The symptoms of ischemia are mainly transient ischemic attack, which may manifest as different degrees of hemiplegia or hemibody weakness, hemisensory impairment, aphasia, monocular vision impairment, etc.
Long-term cerebral ischemia causes cerebral atrophy, cerebral infarction leading to mental decline and dementia symptoms, and some patients present with symptoms such as seizures and headaches.
Hemorrhagic moyamoya disease: occurs more often in adults and presents primarily with intracranial hemorrhage. This is significantly more common in adults than in children.
The basal ganglia and ventricular system are the most common sites of hemorrhage, followed by the thalamic and subarachnoid hemorrhages, and patients present with hemiplegia, aphasia, and impaired consciousness. If left untimely**, rebleeding may occur, significantly worsening the prognosis, with a mortality rate of up to 25%.
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Transient paralysis or weakness.
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Moyamoya disease is more common in children and adolescents, and often begins in the form of stroke, which can manifest as cerebral thrombosis, cerebral hemorrhage and subarachnoid hemorrhage. Patients may have varying degrees of hemiplegia, or paralysis on both sides of the left and right sides, which may be accompanied by aphasia, choking on water, dysphagia, mental retardation, dementia, seizures, headache, and transient ischemic attack. If a child or adult has unexplained headache, limb weakness, numbness, aphasia, epilepsy, blurred vision, or amaurosis fugaurosis of unknown cause, moyamoya disease should be considered.
In addition, some children have low intelligence, slow development, and some mental abnormalities, and they also need to go to the hospital for further examination. Moyamoya disease is manifested as transient cerebral ischemia, headache, epilepsy, limb weakness, paresthesia and visual field changes, while severe cases are caused by cerebral infarction or cerebral hemorrhage, resulting in hemiplegia, aphasia, coma and even life-threatening. Once moyamoya disease develops, it is not only painful, but also causes a gradual decline in intelligence, which can gradually lead to irreversible brain damage.
Therefore, once the diagnosis of moyamoya disease is clear, surgery should be performed as soon as possible, and combined vascular bypass surgery is currently the most effective method for moyamoya disease, which can not only improve the ischemic attack after surgery, but also significantly improve the condition in a short period of time, and improve IQ to varying degrees. The above is a suggestion for the question "Early symptoms of moyamoya disease", I hope it will be helpful to you and I wish you good health!
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