The intrinsic components of complement, which belong to the intrinsic components of complement

Answer]: The intrinsic components of E complement include C1 and C9, of which C1 is composed of three subunits: C1Q, C1R, and Duandou C1S.

Among the intrinsic components of complement, C3 is the most abundant.

There are more than 30 kinds of complement systems, which are widely found in serum, tissue fluid and cell membranes. The chemical nature of complement is actually protein, which is a finely regulated system in the human body. In general, biological functions are only exerted when they are activated.

The main biological function of complement is to play a defensive role in the body's innate immunity, and it is an auxiliary cause of antibodies, which is indispensable in the process of antibodies to play their role. Complement works in such a way that three cross-pathways initiate a series of protein cascades that activate complement to produce functions such as opsonophagocytosis, cell lysis, mediating inflammation, modulating immune responses, and clearing immune complexes.

Function: Code portability

Complement intrinsic components, complement intrinsic components refer to various proteins present in body fluids and plasma that participate in the complement activation pathway, such as: C1Q, C2, and C4 in the classical pathway; factor B and factor D in the bypass pathway; Common components in the activation process C3, C5, C6, C7, C8, C9.

Complement regulatory proteins, which are protein molecules in plasma, on cells, that control complement activation by regulating key enzymes in the complement activation pathway.

Complement receptors, complement receptors are receptor molecules present on the surface of different cells that can bind to active substances formed after complement activation and mediate a variety of complement responses.

The least abundant of the intrinsic components of complement is: factor d.

Complement is a group of proteins that have been activated to have enzymatic activity in the serum and tissue fluid of normal human and moving animals. As early as the end of the 19th century, Bordet proved that fresh blood contains a component that is not heat-resistant, which can assist and supplement specific antibodies, mediate immunolysis and hemolysis, so it is called complement. At present, complement is known to be a multimolecular system composed of more than 30 soluble proteins, membrane-bound proteins and rapid complement receptors, so it is called the complement system.

Complement intrinsic components.

1. C1, C2, and C4 of the classical activation pathway.

2. Factor B, factor D, and factor P of the bypass activation pathway.

3. Mannan-binding MBL and serine proteases of lectin (MBL)-activated pathways.

4. C3, C5, C6, C7, C8, and C9 involved in the common terminal pathway.

Pathways for complement activation.

1. The classical pathway starting from C1Q-C1R2-C1S2, with the antigen-antibody complex as the main activator.

2. An alternative pathway starting from C3, which is independent of antibodies.

3. The lectin activation pathway (MBL pathway) recognized by mannan binding lectin (MBL) glycans.

Complement is not a component, but rather a group of proteins with enzymatic activity that make up the complement system. The system consists of more than 30 glycoproteins, including intrinsic complement molecules, complement regulatory proteins, and complement receptors.

Complement intrinsic components: C1 C9, factor B, factor D.