What does stage 1 and stage 2 of kidney cancer mean, and the relationship between kidney cancer stag

Meaning of stage 1 and grade 3 of kidney cancer: stage 1 refers to patients with stage T1N0M0 in TNM stage, where T refers to the primary tumor, and T1 refers to the lesion confined to the kidney, and the maximum diameter does not exceed 7cm; n refers to regional lymph nodes.

N0 refers to metastases without regional lymph nodes; m refers to distant metastases, and m0 refers to no distant metastases. Grading is an important method in pathology, grade 3 refers to medium differentiation, grades 1 and 2 are well-differentiated, and grade 4 is poorly differentiated or undifferentiated. Among them, high differentiation is relatively sensitive to ** and has a relatively good prognosis, low differentiation is relatively insensitive to **, the prognosis is relatively poor, and medium differentiation is between high differentiation and low differentiation, so kidney cancer stage 1 and grade 3 is early kidney cancer, and the main method is surgery, and the prognosis is relatively good.

The prevention of kidney cancer should be based on the best positioning of kidney cancer, mainly related to smoking, drinking, obesity, occupation, and hypertension.

Radiotherapy, family history, genetics and other factors. At present, the only recognized environmental risk factor is smoking, so quitting smoking in time can reduce the risk. In addition, we should reduce the intake of high-fat and high-energy foods, keep exercising, control weight, avoid obesity, and control hypertension and diabetes.

Reduce the use of certain medications that can cause kidney cancer, such as antipyretics and pain relievers.

Try to avoid the intervention of chemical carcinogens to reduce the incidence of kidney cancer.

TNM staging.

T (primary tumor) stage.

tx: primary tumor cannot be assessed.

t0: no evidence of primary tumor.

T1: Tumor confined to the kidney, up to 7cm in diameter

T1A: tumor confined to kidney, tumor maximum diameter 4cmT1B: tumor confined to kidney, 4cm tumor maximum diameter 7cmT2: tumor confined to kidney, maximum diameter 7cm

T2A: Tumor confined to the kidney, 7cm tumor maximum diameter 10cmT2B: tumor confined to kidney, maximum diameter 10cm

T3: Tumor invasion of renal veins or perirenal tissues other than ipsilateral adrenal glands, but not beyond the perirenal fascia.

T3A: Tumour invades the renal veins or renal veins (myometrious veins) or perirenal and/or sinus fat (parapelvic fat) that does not extend beyond the perirenal fascia.

T3b: tumor invasion of inferior vena cava under the diaphragm.

T3C: tumor invasion of inferior vena cava under the diaphragm or invasion of the inferior vena cava wall.

T4: Tumor invasion of the perirenal fascia (including ipsilateral adrenal glands invading adjacent tumors) N (lymph node metastasis) stage.

NX: Regional lymph node metastases cannot be assessed.

N0: No regional lymph node metastases.

N1: Regional lymph node metastases.

M (distant metastasis) staging.

m0: No long-distance transfer.

m1: There is a long-distance transfer.

Histological grading is often based on the 1982 Fuhrman four-level classification. In 1997, the World Health Organization recommended that the Fuhrman grade be merged into well-differentiated, Fuhrman grade as moderately differentiated, and Fuhrman grade as poorly differentiated or undifferentiated. A grading criterion that classifies kidney cancer into well-differentiated, moderately differentiated, and poorly differentiated (undifferentiated) is recommended.

Staging of the tumor.

Phase I t1 n0 m0

Stage II t2 n0 m0

Stage III t1 or t2 n1 m0

t3 n0 or n1 m0

Stage IV T4 Any n m0

Any t any n m1

In fact, there are still differences between the stage and grade of kidney cancer, so what is the relationship between the stage and grade of kidney cancer?

The stage of kidney cancer refers to the TNM stage, which refers to the size of the primary tumor lesion, which is divided into T1, T2, T3 and T4; n refers to distant metastatic lymph nodes, which are divided into n0, n1, and n2; Carry only M refers to the presence or absence of distant metastases. Clinically, kidney cancer is divided into stage, stage, stage, and stage. Stage and stage belong to the early stage of kidney cancer; Stage belongs to the middle stage of kidney cancer; Stage of kidney cancer is advanced.

According to the principle of kidney cancer staging** and the prognosis of patients. In T1 and T2 stages, the kidneys can be preserved and renal segment resection can be performed; T3 stage requires renal surgery; Traditional surgical resection is not recommended for T4 stage, and local intervention** and targeted drugs ** can be used.

Regular physical examinations: screening for diseases such as kidney cancer, ** cancer, colon cancer, prostate cancer, uterine cancer and breast cancer, the earlier it is detected and **, the greater the likelihood of **. In fact, the physical examination only takes half a day to "toss" it, and it may benefit you for a lifetime.

1.Cancerous tumors are staged and graded. Grade 1-2 means Grade 1 and Grade 2, which is the second stage of early cancer.

2.Cancer tumors are graded according to the degree of malignancy, from low to high, indicating the degree of malignancy, which is used as the basis for clinical ** and prognostic judgment. However, there is no international standard for this classification, some are only divided into 2 levels, and some are classified as 3 or 4 levels.

1) Broders classification Broders (1992) has classified squamous cell carcinoma into 4 grades. Grade I: anaplastic cells are below 25%, and differentiated cells account for 75%; Level II:

anaplastic cells account for 25% to 50%, differentiated cells account for 50% to 75%; Grade III: 50% 75% for anaplastic cells, 25% for differentiated cells; Grade IV: more than 75% of anaplastic cells, less than 25% of differentiated cells.

This grading method has been widely used in other tumors, but it is cumbersome.

2) Level 3 classification This is commonly used at home and abroad, taking **squamous cell carcinoma as an example. Grade I: The arrangement of cancer cells still shows the similar morphology of cells in each layer, basal cells, spinous cells, keratinocytes, and intercellular bridges and keratinized beads; Level II:

The cell differentiation is poor, the difference between the cells in each layer is not obvious, and individual cells with poor keratinization can still be seen; Grade III: no spinous cells, no intercellular bridges, no keratinized beads, and a few cells have a slightly squamous cell morphology. The 3-level taxonomy can be expressed as either i, ii, or iii, as well as high-differentiation, moderately differentiated, or low-differentiated.

Various adenocarcinomas can also be roughly classified into three grades according to their glandular duct structure and glandular cell morphology. Other malignancies are graded by analogy according to the above examples.

Level 2 is considered more serious.

The reason why cancer is terrible is that the growth rate of kidney cancer masses is relatively rapid, most of the early kidney cancer is asymptomatic, and the general patient is found to be in the middle and advanced stages, and the impact on the patient's life is even greater. In order to take effective prevention and control measures before the onset of the disease.

It should be stage 2 kidney cancer, which is the pathological stage of kidney cancer. Stage 2 kidney cancer is relatively easy to treat, and the prognosis is also better.

It should be stage 2 kidney cancer, which is the pathological stage of kidney cancer, indicating the severity of the disease.

Although early-stage kidney cancer is only early, it is also malignant, so how malignant is early-stage kidney cancer?

If we simply talk about the classification of kidney cancer, it mainly refers to the histological classification of kidney cancer, and the most commonly used is the Fuhrman grade. However, there is also a TNM stage for kidney cancer, which is also very important for the prognosis of kidney cancer. The method of determining Fuhrman grading is to observe cancer cells with a microscope and grade them according to their nuclear morphology.

Grade I: Well-differentiated Grade II: Well-differentiated Grade:

Medium differentiation grade: low differentiation (undifferentiated) differentiation refers to the degree of differentiation of the nucleus, the degree of differentiation is opposite to the degree of heterosexuality, if the degree of differentiation is high, indicating that the atypia is smaller, the better the prognosis; If differentiation is low, it indicates high atypia and poor prognosis.

This degree of differentiation is compared to that of normal kidney cells, and the more it deviates from normal cells, the lower and more severe the differentiation becomes. Fuhrman grade is an independent influencing factor of kidney cancer prognosis, the higher the Fuhrman grade, the worse the prognosis, that is, the greater the possibility of occurrence and metastasis in the future, the higher the risk of the tumor, and the faster the progression of the disease.