The use of pyrazole salt, the main use of pyrazole

Sedative-hypnotics.

This product selectively binds to the 1-receptor subtype in the central nervous system and has low affinity for the 2- or 3-receptor subtype. Healthy subjects took a small dose of this product (5 a), and the results were shortened and the sleep time was prolonged; When taken orally at 10 to 20 mg or higher, phase 2 sleep, slow-wave sleep (phase 3 and 4 sleep) and rapid eye movement phase (REM) sleep latency are prolonged, and REM sleep duration is shortened. After insomnia patients take this product, the sleep quality and morning mental state are equivalent to or better than benzodiazepine (zhuo) drugs, and the patient's memory or mental state when awake is not affected when taking 10-20mg at night.

Resistance and dependence were observed in 138 elderly and adult patients with insomnia after taking this product for up to 1 year. This product does not have obvious anticonvulsant and muscle relaxant effects.

Clinically, it is mainly used for sleeplessness and anxiety.

The most common adverse reactions are dizziness ( headache ( drowsiness ) and gastrointestinal disorders, but the drug resistance, dependence and withdrawal effect of this product are small.

Patients with impaired liver and kidney function should reduce the dose. Use with caution if driving or machinery operators.

Pyrazole has a variety of physiological effects, including analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxing, mental excitement, antispasmodic, monoamine oxidase inhibitor, anti-diabetic, and antibacterial. Pyrazole can be used as an intermediate of some pharmaceuticals and pesticides, and occupies a very important position in the research and development of pharmaceuticals and pesticides. Pyrazole compounds have attracted more and more attention due to their wide spectrum of action and strong efficacy.

In pharmaceutical applications, pyrazoles have curative effects on many diseases; In pesticide applications, pyrazole compounds have insecticidal, bactericidal and herbicidal activities, and exhibit high efficiency, low toxicity and structural diversity. Therefore, pyrazoles have broad research and development prospects. Pyrazole can also be used as a side chain for monomers of certain photosensitive materials and has a wide range of applications.

In addition, pyrazole also corrects error |It is used as a stabilizer, chelating agent and organic synthesis intermediate for halogen-containing solvents and lubricating oils.

Manufacturing Method: Glycerol (glycerol) and hydrazine hydrate are used in sulfuric acid solvents to use cheap and easily available sodium iodide (catalytic amount) as a dehydrogenation catalyst to synthesize pyrazole in one step, and then neutralized to pH = 7-8 with liquid alkali, filter out inorganic salts, dehydrate the mixed solution with benzene reflux water, and then vacuum distillation to obtain the finished pyrazole. Its combined yield is up to: It can also be through the reaction of unsaturated aldehydes and hydrazine, and then dehydrogenation to synthesize pyrazole.