What to do if drug resistance develops during chemotherapy? How can it be effectively improved?

When resistance to chemotherapy develops, chemotherapy regimens and drugs should be changed. Chemotherapy is generally divided into first-line, second-line, and third-line regimens, and if first-line regimens are resistant or fail, they are replaced with second-line regimens. However, after multiple changes to chemotherapy drugs, multidrug resistance can occur.

Some cancer patients who have developed resistance to chemotherapy and have a poor response to chemotherapy may also be considered**. However, resistance to targeted ** can still occur.

In past clinical practice, the combination of traditional Chinese medicine and chemotherapy has certain significance in reducing or stopping chemotherapy resistance. Recently, studies have been carried out on the intervention of traditional Chinese medicine (TCM) in chemotherapy resistance, especially multi-drug resistance, but due to the constraints of conditions, the research is not in-depth enough to elucidate the mechanism.

There are many factors that lead to drug resistance, both internal and external, and comprehensive analysis is required to arrive at a relatively accurate understanding. It is advisable to go to your attending physician, under this platform, even other doctors, no matter how savvy, can hardly give a responsible answer with the current knowledge.

In the same situation as when my second aunt got a tumor, my second aunt also had drug resistance during chemotherapy, and then we inquired and learned that many patients with this situation now choose to take Mycosan fungus nutrition intervention to regulate and improve, so my second aunt was also equipped with a fungus nutrition intervention program, as far as I know, the fungus nutrition intervention can help the human body to remove the toxins produced in the body during chemotherapy, and can also effectively reduce the toxicity and resistance of drugs to the human body My second aunt has a good effect after taking it.

Chemotherapy resistance can be carried out through drugs**, surgery**, targeting**, radiation**, etc., and the specific measures are as follows:

1.Drugs**.

Generally, after a period of chemotherapy, the patient's body will have drug resistance, and then it can be carried out by changing the chemotherapy drug**, or the patient will be tested for the sensitivity of the chemotherapy drug first, and the targeted chemotherapy drugs will be selected according to the sensitivity test results, the main drugs include paclitaxel injection, cisplatin injection, etc.

2.Surgery**.

Resistance to chemotherapy drugs may also be caused by increased tumor burden, which requires surgical resection of the lesion.

3.Targeting**.

For some well-defined carcinogenic sites, recovery can be promoted by targeting**, including argon-helium knife, radiofrequency ablation, high-intensity focused ultrasound, radioactive particle implantation in the interstitial irradiation**, photodynamic**, etc.

4.Radiation**.

After chemotherapy resistance, it can also help the recovery of the disease through radiation**, which is to use radiation to destroy cancer cells to achieve the purpose. The main methods include Gamma Knife, X-Knife, Cyberknife, etc.

Long-term chemotherapy may cause damage to intestinal mucosal cells, so it is necessary to pay attention to a light diet and avoid excessive spicy, greasy or indigestible food. Avoid sitz baths or saunas when bathing to avoid catching a cold after sweating profusely, and the prognosis still needs to be checked regularly to avoid the disease** or spread.

It is not good to develop resistance to chemotherapy drugs.

Drug resistance, also known as drug resistance, generally refers to a state in which a pathogen responds less to a drug. It is due to the long-term use of antimicrobial drugs, when the dosage is insufficient, the pathogen is produced by producing enzymes that inactivate the drug, changing the membrane permeability to block the entry of the drug, changing the target structure, or changing the original metabolic process. Severe drug resistance can render a variety of antimicrobial drugs ineffective.

Therefore, during chemotherapy, if drug resistance develops, the effect of the drug on killing cancer is poor, and chemotherapy is of little significance. It is recommended to take Selenium Vikang chewable tablets to supplement the trace element selenium during chemotherapy, which can reduce the *** produced by chemotherapy and inhibit the drug resistance of cancer cells.

When drug resistance develops, drugs are less effective at killing cancer.

Of course, it is not good, once there is a lesion in the human body or the infection caused by the invasion of external bacteria, the first thing is to pass through the lymph glands, and the white blood cells are not able to kill the cancer cells, so the external chemotherapy is to assist it in annihilating the cancer cells that remain in the diseased tissue after surgery, but the difference is that it not only kills cancer cells but also kills normal cells and tissues, so chemotherapy patients often have white blood cell hemoglobin and so on much lower than the healthy value, if the cancer cells produce drug resistance, Chemotherapy doesn't make much sense, follow the doctor's advice to see if you can change the chemotherapy drug, or take traditional Chinese medicine conservatively**, go to Beijing and other big hospitals to see.

Tumor drug resistance refers to the tolerance of tumor cells in cancer patients to the chemotherapy drugs used in the chemotherapy process, and once the body develops drug resistance, the effect of chemotherapy drugs is significantly reduced, and it is almost impossible to kill cancer cells. According to the causes of drug resistance, drug resistance can be divided into natural drug resistance and acquired drug resistance; According to the characteristics of drug resistance, we divide drug resistance into drug resistance and drug resistance.

Natural resistance refers to resistance that is known before chemotherapy is started; Acquired resistance is the gradual acquisition of drug resistance by tumor cells during chemotherapy. Drug resistance refers to the fact that tumor cells are no longer sensitive to one of the current drugs, but are still sensitive to other different types of drugs; Multidrug resistance is even more troubling, as the name suggests, because resistance to a variety of chemotherapy drugs has developed.

Consequences of drug resistance.

Chemistry is an important means of cancer, but once drug resistance appears, it will not only affect the effect of chemotherapy, but also aggravate the toxicity of chemotherapy drugs to normal cells in the human body.

Ways to combat drug resistance.

If resistance to the original drug develops, other types of chemotherapy drugs may be chosen. Some of the countermeasures we take are generally to change the body's multidrug resistance.

1) Chemical reversal agents This is the most important means to solve tumor drug resistance, including calcium channel blockers (such as isobodine, nicodine), immunomodulators, steroid hormones (megestrol, progesterone), estrogen antagonists (tamoxifen, toremifene ), antimalarial drugs and antiarrhythmic drugs (quinine, quinidine) ......However, the biggest disadvantage of reversal agents is that most of them are toxic, so they are limited in clinical application.

2) Traditional Chinese medicine Guben Peiyuan's traditional Chinese medicine is not only less toxic, but also can improve the body's immunity, and also has the effect of increasing efficiency and reducing toxicity in the process of chemotherapy, such as saponin monomer RH2 extracted from ginseng, a traditional Chinese medicine in China, has been proven to be able to help the body restore the body's immunity after chemotherapy, reduce toxicity, and improve the quality of life and survival rate of patients.

3) Biology includes immunity and genes.

Hello to this! After chemotherapy, the body is fine, it should be said that it is more sensitive to chemotherapy, but you should not be careless, and you must continue to have regular reexaminations**. Chemotherapy itself has ***.

Using Chinese medicine, Chinese medicine is OK.

Radiotherapy and chemotherapy not only kill cancer cells, but also kill normal cells, and can also lead to gastrointestinal dysfunction, bone marrow suppression, etc., which greatly reduces the quality of life of patients. Selenium can play a role in detoxification and synergy in four aspects.

1. Selenium can enhance immunity.

Organs such as lymph nodes, liver, and spleen in the human body have high levels of selenium, and these tissues are the concentration of immune cells. Therefore, selenium supplementation can effectively improve the immunity of patients with chemoradiotherapy and enable them to successfully complete chemoradiotherapy.

2. Selenium can reduce the toxicity of chemotherapy.

Taking a larger dose of selenium before and after chemotherapy can reduce leukopenia, nausea, vomiting, loss of appetite, severe hair loss, lymphedema and nephrotoxicity.

3. Selenium can reduce the resistance of chemotherapy drugs.

Long-term chemotherapy can cause malignant tumor cells to become resistant to drugs. It has been reported that high-dose selenium supplementation can significantly reduce the resistance of malignant tumor cells to chemotherapy drugs, so that they are always sensitive to the preservation of the value of chemotherapy drugs.

Fourth, selenium can scavenge harmful free radicals.

Radiotherapy and chemotherapy for cancer patients produce a large number of harmful free radicals by the body, which leads to a variety of occurrences. Studies have found that selenium is a strong antioxidant, selenium can quickly improve the body's antioxidant capacity, remove harmful free radicals, and reduce the risk of radiotherapy and chemotherapy. It is worth mentioning that the good ** results in these studies all rely on high doses of selenium, and the effective dose of selenium is similar to the toxic dose, and there are safety risks that are difficult to control with large doses of selenium.

Therefore, patients must choose safe and efficient selenium supplementation products (e.g., Selenium Wang Capsule - Nano Selenium) to ensure their own safety.