What to do if the body develops drug resistance due to frequent antibiotics Experienced doctors come

The three upstairs were obviously cheating.

First, your symptoms are likely to be very serious, so you will take antibiotics for ten years in a row, and they have not been cured for ten years, which shows that your drug resistance is already very serious.

Second, you are likely to run into quacks, and high-level doctors will not use these two types of antibiotics for ten consecutive years.

Third, your communication with the doctor is so poor, and you know the types of drugs you use in such detail, why don't you communicate with the doctor well before the appointment?

Ten years of antibiotics have not cured your disease, and now your condition is urgent, and according to the symptoms you said, it is likely that your disease is in the lungs.

First of all, if you are allergic to penicillin, then it is best to use cephalosporin antibiotics, you are taking injections, then it is recommended that you choose ceftriaxonena, this drug from Baiyunshan Pharmaceutical General Factory and Federal Pharmaceutical General Factory is the best effect I have ever used.

If there is no effect, immediately replace it with a third-generation cephalosporin, cefixime.

Of course, now I am talking about medicine on paper, and I don't know your detailed symptoms, and I can't be 100% sure of your medication.

This is just a suggestion, you can talk to your doctor.

As for traditional Chinese medicine, alas, in the field of traditional Chinese medicine, especially in the industry of ** diseases like yours, there are very, very few good doctors, and you have used antibiotics for ten years without getting your lung disease, it is estimated that Chinese medicine will cure your disease Liao Liao.

In addition, it is highly recommended that you go to the hospital for an antibiotic resistance test to find out which antibiotic your body is resistant to.

Your body is like this, and you don't need health care products to recuperate! The general disease is not good, but long-term antibiotics can be fatal. Cordyceps can target your disease.

With bezoar anti-inflammatory capsules, the effect of hot tablets is better, and it is better than hanging a drip for respiratory tract infections and pneumonia, and it is not ***.

With normal use of antibiotics, resistance to antibiotics does not develop in normal individuals. The reasons for drug resistance are: first, long-term use of a certain drug, drug resistance may occur; The second is drug abuse. For example, if antibiotics are used for inflammation that is not a bacterial infection, the body will easily "remember" this superfluous thing, which will reduce its sensitivity to the components of this drug; 3. Failure to take medication in accordance with the dosage and course of treatment specified in the doctor's instructions or instructions.

Many people take antibiotics because the symptoms are reduced or disappeared and they feel that they are cured, and they stop taking antibiotics without authorization, which is also the reason why the antibiotics they take are easy to develop resistance.

These phenomena are extremely common, especially the latter two, which are artificially created to resist drugs.

Therefore, it is necessary to understand some common sense, antibiotics are used only for bacterial infections, and antibiotics should not be used for non-bacterial infections. When you see a doctor, be sure to ask, "Do I have a bacterial infection?" and don't take antibiotics if it's not a bacterial infection. Doctors generally say "you have inflammation", do not tell the patient what inflammation is, whether it is inflammation or bacterial infection or viral infection, and also prescribe antibiotics when prescribing drugs.

In short, the correct use of antibiotics can minimize the resistance of the body.

If you stop eating, you may develop resistance after a few months, so antibiotics must be used according to the instructions.

Antimicrobial resistance, also known as antimicrobial resistance, refers to the decrease or even disappearance of the sensitivity of bacteria to antibiotics after repeated contact with antibiotics, resulting in the reduction or ineffectiveness of antibiotics against drug-resistant bacteria.

There are three main ways in which antimicrobial resistance develops in bacteria:

1.Two inactivating enzymes are produced. One is hydrolase, which can hydrolyze penicillin and cephalosporins; The second is synthetase, which can catalyze the binding of certain groups to antibiotics such as aminoglycosides and inactivate them.

2.Altered cell membrane permeability in bacteria. Bacteria can make antibiotics difficult to enter the bacteria through various ways, such as the outer cell membrane of some bacteria has a natural barrier effect on penicillin; In addition, some bacteria can be resistant to antibiotics through changes in cell wall water pores or extracellular membrane channels, making it difficult for antibiotics to penetrate into the bacteria.

3.The target structure in bacteria is altered, making it difficult for antibiotics to bind to it.

To sum it up, that's all there is:

1. Produces beta-lactamase, inactivates antibiotics, 2. Changes the permeability of the cytoplasm, increases efflux, 3. Isomerism or mutation of the target site, like antibiotics have no effect on the target site.

It's all in microbiology and pharmacology textbooks...

The following is what the encyclopedia says, which is quite reliable, 1) produces inactivated enzymes.

There are two types of inactivating enzymes, one is hydrolase, such as -lactamase, which hydrolyzes penicillin or cephalosporin. The enzyme can be chromosome- or plasmid-mediated, and some enzymes are produced as constitutional (histomase); Others can be induced (induced enzymes). The second is passivating enzymes, also known as synthases, which can catalyze the binding of certain groups to the OH or NH2 groups of antibiotics to inactivate antibiotics.

Most gram-negative bacilli resistant to aminoglycoside antibiotics produce plasmid-mediated passivation enzymes, such as acetyltransferases on NH2 groups and phosphotransferases and nucleoside transferases on OH groups. The above-mentioned enzymes are located in the extracytoplasmic space, and after being passivated by the above-mentioned enzymes, aminoglycosides are not easy to bind to the nucleosomes in bacteria, thus causing drug resistance.

2) Change the permeability of bacterial cytoplasmic membrane.

Bacteria can make it difficult for antimicrobial drugs to enter the bacteria through various ways, such as the outer cell membrane of gram-negative bacilli has a natural barrier effect on penicillin G; Pseudomonas aeruginosa and other gram-negative bacilli cell wall water pores, or non-specific channel function changes in the outer membrane, causing bacterial resistance to some broad-spectrum penicillins, cephalosporins, including some third-generation cephalosporins; Bacterial resistance to tetracycline is mainly due to the fact that the drug-resistant plasmid can induce the production of three new proteins, which blocks the cell wall water pores and makes the drug unable to enter. In addition to the above-mentioned passivation enzymes, gram-negative bacilli resistance to aminoglycosides can also be difficult to penetrate into bacteria due to changes in cell wall water pores.

and 3) changes in the structure of the target site in bacteria.

The p10 protein at the target site of streptomycin on the 30S subunit of the bacterial nucleoproteosome of the streptomycin-resistant strains was changed. The resistance of lincomycin and erythromycin is caused by the change of the target protein on the 23S subunit of the bacterial nucleoteosome, so that the drug cannot bind to the bacteria. Resistance to penicillin G in some gonorrhoeae and methoxybenzenicillin in Staphylococcus aureus is due to mutations in the penicillin-binding protein that make it difficult for the drug to bind. This resistant strain is often resistant to other penicillins and cephalosporins as well.

Drug resistance, also known as drug resistance, refers to the reduced sensitivity of pathogens and tumor cells to chemical drugs. When a drug fails to kill or inhibit the pathogen, the term resistance is equal to drug dose failure or drug tolerance. It also refers to the situation that the same dose is not as effective as the original due to long-term medication.

In order to maintain the effectiveness of antibiotics, attention should be paid to their rational use.

If you don't use it properly, you can become resistant.

Resistance to drug, also known as drug resistance, refers to the tolerance of microorganisms, parasites and tumor cells to the action of chemotherapy drugs. Antimicrobial resistance can be divided into acquired resistance and natural resistance according to the cause of its occurrence. Natural resistance can also occur in pathogens in nature, such as a strain of bacteria.

When antibiotics are used for a long time, the majority of susceptible strains are continuously killed, and drug-resistant strains multiply in large numbers to replace sensitive strains, so that the bacterial resistance rate of the drug continues to increase. The latter modality is currently thought to be the main cause of the development of drug-resistant bacteria. In order to maintain the effectiveness of antibiotics, attention should be paid to their rational use.

In the process of using antibiotics, if they are used for a long time, the bacteria in the body will have a certain resistance to antibiotics.

Therefore, the current measures for how to overcome antibiotic resistance are to discover other antibiotics as much as possible and develop a new generation of antibiotics for **. In addition, you can also choose to reduce the improper use of antibiotics to control antibiotic resistance as much as possible, especially for children and the elderly, in the process of using antibiotics, it is more important to grasp the appropriate dosage to carry out**, otherwise the infection will last for a long time, leading to more serious diseases.

At the beginning, because people did not understand bacteria and lacked understanding of diseases, once the wound appeared, once there was an infection, it would lead to death, and at this time, infectious diseases were also some infectious diseases that were very difficult to effectively control.

It could take a lot of lives. Later, scientists developed the first antibiotic called penicillin.

It can kill the bacteria in many diseases, and later with the continuous development of medical technology, it has gradually been discovered that some other antibiotics have also been used, so that many diseases have also been effective.

Antibiotic resistance is mainly due to the frequent use of antibiotics, and the process of use is not standardized, so every time in the process of use, the bacteria that leave resistance after the elimination of antibiotics by non-resistant bacteria will make all bacteria resistant after long-term mutations. And everyone's body's ability to metabolize drugs is different, so in some people, this drug may be able to play a good role, while in others, because of the strong metabolic ability, the drug concentration will not reach the best effect, resulting in a certain degree of drug resistance.

Finally, what you can find now is that you must not abuse antibiotics at will, so you must choose antibiotics carefully in the first disease, and antibiotics will more or less appear in the body, which will destroy the beneficial bacteria in the body.

To avoid antibiotic resistance, we need to pay attention to the time of medication and avoid prolonged medication that causes bacteria to be insensitive to this antibiotic. Pay attention to the type of antibiotics during the medication, pay attention to the proper use, avoid large doses, and be sure to use the drug under the guidance of the doctor.

You can exercise regularly, drink plenty of water, and eat plenty of fruits and vegetables. In this way, antibiotic resistance can be overcome. No other antibiotics have been found, and general antibiotics may not be acceptable to your body.

You can drink plenty of water, you can exercise, and you can also take some medications. In this way, antimicrobial resistance can be overcome. No other antibiotics have been identified.

Unreliable, the hazards of antibiotics include the following:

1. Long-term use of antimicrobial drugs can lead to intestinal flora disorders and cause secondary infections, including bacterial and fungal infections.

2. Long-term application or over-application, and the application of antimicrobial drugs without indications can cause bacterial resistance.

3. Antibacterial drugs have different degrees of adverse reactions, such as common aminoglycoside drugs, which damage the kidneys, among which streptomycin and gentamicin can damage hearing, macrolide drugs have a relatively high probability of liver damage, tetracycline drugs can cause tetracycline teeth in children, vancomycin can damage kidney deficiency, linezolid has obvious platelet decline, quinolones and carbapenems often have neurological toxicity, Many antimicrobial drugs have varying degrees of ***.

4. Antibiotics can cause allergies, mild cases can be manifested as allergic urticaria, severe cases can appear anaphylactic shock, and the use of vancomycin can also cause red man syndrome, so there are advantages and disadvantages of antimicrobial drugs.