What causes muscle wasting?

Muscle atrophy is divided into physiological and pathological, physiological is generally called disuse atrophy, it is caused by some reasons that cause the patient's whole body or part of the muscles to be unable to move for a long time, resulting in muscle tissue or muscle fiber volume reduction, muscle fiber reduction resulting in muscle atrophy, this atrophy can be slowed down or even avoided by passive movement. Pathological muscle atrophy is divided into neuronal and myogenic muscles, and neuronal is manifested as muscle atrophy because the nerve is damaged and causes a decrease in the volume and number of muscle cells. The other is a disease of the muscles themselves, called myogenic diseases, which cause muscle atrophy after the volume or number of muscle cells decreases.

These two conditions should be treated differently according to different methods, and the prognosis of pathological muscular atrophy is not very good. The above content is for reference only, and the specific medication and ** please be subject to the doctor's face-to-face guidance.

Hello, there are many factors about the causes of muscle atrophy, and the main factors are as follows:

The most common causes of muscle dystrophy are nutritional disorders, disuse, poisoning, and ischemia. Lesions of nerve roots, anterior horns, peripheral nerves, plexus, etc., will cause conduction disorders of nerve excitatory impulses, and then make some muscle fibers useless, resulting in muscle atrophy. When any part of the motor neuron is damaged, the release of acetylcholine from its terminal parts decreases, and the sympathetic neurotrophic effect is weakened, resulting in muscle atrophy.

On the other hand, muscle atrophy is caused by the disease of the muscles themselves, and may also include some other factors, such as muscular dystrophy in patients with shoulder girdle or facescapulohumeral type, confirmed by morphological examination.

Muscle atrophy is a very serious condition, and it is also very stubborn, and it is also very difficult. After suffering from muscle wasting, patients not only have to endure a lot of pain, but also have a normal life. The most common cause of muscle wasting is nerve damage.

If the nerve is damaged, it is easy to cause muscle atrophy, for example, after some surgery, or if you have suffered a trauma, burn, or fracture, but you have not recovered well, resulting in nerve damage, it will cause muscle atrophy.

The risk of muscle atrophy is related to many factors, such as neurological diseases or muscle damage to the muscles themselves, such as trauma. It is more common in people who are bedridden and overexercised, or in patients with progressive malnutrition and motor neuron disease. Diseases such as lumbar disc herniation and anorexia can also induce this disease.

1. Genetic factors: It usually occurs in adolescents, also known as pseudohypertrophic muscular dystrophy. At present, there is no targeted method, and there is a certain danger that will endanger life.

2. Nervous system diseases: generally polio, cerebral infarction and other diseases, neuropathy causes nerve conduction disorders, resulting in the disuse of some muscle fibers, weakened exercise ability and muscle atrophy.

3. Trauma: When traumatized, you may stay in bed for a long time**, and your muscles will atrophy if you don't move for a long time. In addition, if the spinal cord is damaged due to a fracture, the nerve compression may also cause muscle atrophy.

4. Motor neuron disease: It is a series of chronic progressive neurodegenerative diseases with more than or lower motor neuron damage as the prominent manifestation.

5. Other diseases: such as lumbar disc herniation, cervical spondylosis, malnutrition, Cushing's syndrome, myositis and other diseases, can also cause muscle atrophy.

The causes of muscle atrophy include neurogenic amyotrophy, myogenic amyotrophy and disuse amyotrophy, ischemic amyotrophy, neurogenic amyotrophy refers to the neuromuscular junction before the neuromuscular junction of the nerve structure, resulting in amyotrophy, generally the onset is more rapid, the progression is relatively rapid, the lesion involves the anterior horn cells of the spinal cord can occur muscle atrophy, generally seen in acute poliomyelitis, progressive spinal muscular atrophy and amyotrophic lateral sclerosis.

Amyotrophy can also occur when the site of injury is located in the nerve root or nerve trunk, which is common in lumbosacral trauma and cervical spondylosis. Lesions of multiple nerve roots or plexus often present with predominantly proximal amyotrophy, mainly in acute inflammatory demyelinating polyneuropathy, commonly known as Guillain-Barré syndrome. Mononeuropathy can produce innervated amyotrophy, such as due to damage to the radial or median nerves.

Myogenic amyotrophy is generally caused by muscle diseases caused by muscle atrophy, mainly refers to the neuromuscular junction protruding after the posterior membrane lesions, general diseases include progressive muscular dystrophy, myotonic dystrophy and myositis and other diseases. Disuse amyotrophy is common in amyotrophy due to upper motor neuron damage such as cerebrovascular disease, or due to immobility due to coma, and ischemic amyotrophy due to musculovascular disease.

Most of the muscle wasting is due to neuropathy.

There are several causes of muscle atrophy, first of all, it is caused by muscle diseases, myositis such as polymyositis, and patients will have muscle atrophy and muscle damage. Secondly, patients with myasthenia gravis, there is a type of myasthenia gravis that is amyotrophic type, and patients can also develop muscle atrophy.

There are also diseases of the peripheral nerves, such as diabetes, and the situation caused by metabolic factors after poisoning, or autoimmune factors, resulting in more serious muscle atrophy, which is caused by neurological factors caused by peripheral neuropathy.

Central nervous system, such as spinal cord lesions, can also cause muscle atrophy, and patients generally present with upper motor neuron paralysis, in addition to muscle atrophy, patients will show signs of muscle hypertonia, which is caused by the lesion. There is also a kind of disuse atrophy, such as the patient who is on bed rest during the immobilization period after a fracture, and muscle atrophy will occur after a few months, which is a disuse factor, and the muscle atrophy caused by the patient walking less.