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Anonymous users2024-02-16Antan, also known as trihexyphenidyl hydrochloride, is an anti-tremor paralysis drug. The main pharmacological effects are to block the central cholinergic receptors, weaken the effect of acetylcholine in the substantia-striatal pathway, reduce the excitability of the reticulum-thalamus and thalamic-cortical projection systems, and exert anticholinergic and anti-tremor effects.
In neurology and psychiatry, it is mainly used for paralysis treminus (Parkinson's disease) and extrapyramidal reactions caused by psychotropic drugs, such as akathisia, acute dystonia, movement disorders, muscle and limb tremors, and eye turning (oculomotor crisis). Therefore, the probability of using Antan in psychiatry is higher.
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Anonymous users2024-02-15Because sometimes doctors do not explain the role and purpose of Antan to patients and their families, many patients' family members have many misunderstandings about Antan, resulting in confusion in the process of taking medicine.
Myth 1: Antan is a sleeping pill. As the dose of psychotropic drugs increases, the psychiatric symptoms are reduced or disappear, and the patient's sleep improves or increases, and the patient sometimes mistakenly thinks that this is the credit of the psychotropic drug, and it also has the same "An" character as other sleeping pills.
In fact, this increase in sleep is mainly caused by the increase in the dose of psychotropic drugs to improve the condition, the patient's low tolerance to the drugs, and the prevention of extrapyramidal reactions by Antan, so the condition is relatively stable. In order to reduce the patient's sleepiness, some family members who think they are smart stop taking Antan without authorization, and as a result, there is a drug reaction, and the patient is anxious and difficult to sleep.
Myth 2: Why do "sleeping pills" not sleep. Some patients with anxiety and depression often have sleep disorders, or the patient's family members are worried about the patient's poor sleep and simply take Antan to solve the pain of insomnia.
Myth 3: Why is it painful and uneasy to stop taking Antan? Some patients have anxiety, nervousness, akathisia, increased muscle tone, ataxia, etc., which make the patient very frightened and distressed, which is caused by the loss of the side effects of Antan antagonistic psychotropic drugs.
Clinical work has also found that some patients who take Antan for a long time can produce dependence (mental or physical dependence), and once the drug is stopped, it can also cause nervousness, anxiety, fatigue, restlessness, depression, insomnia, sweating, etc., which is the withdrawal reaction of Antan.
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Anonymous users2024-02-14Hello. Antan tablets are also known as trihexyphenidyl hydrochloride tablets.
Drug category: Anti-tremor paralysis drug.
Character: This product is a white tablet.
Pharmacology and toxicology This product is a central anticholinergic and anti-Parkinson's disease drug, which selectively blocks the cholinergic neural pathway of the striatum, and has less peripheral effect, which is conducive to restoring the balance of dopamine and acetylcholine in the brain of patients with Parkinson's disease and improving the symptoms of Parkinson's disease.
Pharmacokinetics After oral administration, the absorption is fast and complete, it can penetrate the blood-brain barrier, and the effect of oral administration takes effect for 1 hour, and the effect lasts for 6 to 12 hours. 56% of the dosage is excreted in the urine, and the excretion is slowed down in case of renal insufficiency, which has an accumulation effect and can be secreted from breast milk.
Indications for Parkinson's disease, Parkinsonism. It can also be used for drug-induced extrapyramidal diseases.
Dosage Oral Parkinson's disease, Parkinson's syndrome, start 1 2mg a day, then increase 2mg every 3 5 days, until the best effect and no side effects, generally no more than 10 mg a day, divided into 3 4 times, must be taken for a long time. Maximum dose of 20mg daily. For drug-induced extrapyramidal disease, 2 4 mg is taken in 2 3 divided doses on the first day, and then gradually increased to 5 10 mg as needed and tolerated.
Older patients should reduce the dose as appropriate.
Adverse reactions: Dry mouth, blurred vision, etc., tachycardia, nausea, vomiting, urinary retention, constipation, etc. are common. Long-term use may cause drowsiness, depression, memory loss, hallucinations, and confusion.
Contraindications Patients with glaucoma, urinary retention, and prostatic hypertrophy.
Precautions. Pregnant and lactating women should be used with caution.
Children's medication should be used with caution.
Medication for elderly patients Long-term use in the elderly is prone to promote glaucoma. Patients with arteriosclerosis are prone to confusion, disorientation, anxiety, hallucinations, and psychotic symptoms with the usual amount of antiparkinsonian drugs. Use with caution.
Drug Interaction 1. When this product is combined with ethanol or other central nervous system inhibitors, the central inhibitory effect can be strengthened. 2. When this product is used in combination with amantadine, anticholinergics, monoamine oxidase inhibitors Pajilin and procarbazine, it can strengthen the anticholinergic effect and cause paralytic intestinal obstruction. 3. This product is used in combination with monoamine oxidase inhibitors, which can cause hypertension.
4. When this product is used in combination with antacids or adsorption antidiarrheal agents, the effect of this product can be weakened. 5. When this product is combined with chlorpromazine, the metabolism of the latter is accelerated, which can reduce its blood concentration. 6. The combination of this product and cardiac glycosides can prolong the residence time of the latter in the gastrointestinal tract, increase absorption, and make it easy to be poisoned.
Drug overdose Symptoms of poisoning: Pupilia, increased intraocular pressure, palpitations, tachycardia, dysuria, weakness, headache, redness, fever, or abdominal distension may be seen in overdose. Sometimes it is accompanied by toxic psychotic symptoms such as delirium, delirium, delusions, and hallucinations.
In severe cases, coma, convulsions, and circulatory failure may occur. Treatment: Induce vomiting or gastric lavage, take measures to increase excretion, and treat symptomatic ** and support ** according to the condition.
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