Do patients with multiple system atrophy have any symptoms?

Multiple system atrophy is a degenerative disease that often affects multiple sites of the pyramidal system, extrapyramidal system, cerebellum, and autonomic nervous system. The main manifestations are Parkinson's disease-like symptoms, which are manifested by progressive muscle rigidity, bradykinesia, gait disorders, cerebellar damage, slow movements, forward gait, difficulty in changing postures, and positional tremor.

1. Autonomic nervous system failure, mainly manifested as impotence (male), urinary incontinence (female), orthostatic hypotension, hypohidrosis, paleness, constipation, etc. 2. Symptoms of treminism, manifested by decreased movement and rigidity; Such patients have different efficacy to levodopa at different stages of development, and the early response is better. 3. Pyramidal tract signs are manifested as increased muscle tone, hyperreflexia, and pathological reflexes.

4. Cerebellar symptoms, which are mainly manifested as gait instability and ataxia, intention tremor, and nystagmus. 5. Others; Dysarthria is seen in almost all patients with multiple system atrophy. In addition, there are dysphagia, limited eye movement, rapid saccade movement disorder, respiratory stridor, and distal myoclonus.

Patients may also have sleep apnea and REM sleep behavior abnormalities. Patients with multiple system atrophy generally develop rapidly after the onset of symptoms, which seriously affects the quality of life of patients with multiple system atrophy and is life-threatening, and the survival time of patients with multiple system atrophy is not related to the type of disease, the gender of the patient, and whether they have tremor paralysis and pyramidal signs. In general, the older the patient, the worse the prognosis.

The typical symptoms of multiple system atrophy are: striatal substantia nigra lesions, which are more common in men than in women, and mainly manifest as parkinsonism-like symptoms, such as bradykinesia, creeping gait, and progressive muscle disorder; Olivepontine cerebellar atrophy.

Cerebellar dysarthria: patients sometimes speak slowly, speak clearly, and occasionally have explosive speech, which is characterized by chattering and chattering.

Symptom. The age of onset of MSA is mostly in middle age or early old age (32-74 years), and 90% of them are significantly earlier than idiopathic Parkinson's disease at the age of 40-64 years, with a disease duration of 3 to 9 years.

There are three main clinical signs: cerebellar symptoms, extrapyramidal symptoms, and autonomic symptoms. Of these, 89% developed parkinsonism; 78% had autonomic failure; Cerebellar ataxia occurs in 50%.

The most common combination is parkinsonism with autonomic failure or cerebellar ataxia with autonomic failure. In addition, a significant proportion of patients may have pyramidal tract signs, brainstem damage (paralysis of extraocular muscles), and cognitive dysfunction.

The clinical features are:

1.Insidious onset, slowly progressive, and progressively worsening.

2.From a single system to a multi-system system, each group of symptoms can appear sequentially, overlapping and combined.

SND and OPCA are more likely to evolve into MSA. Xu Xiaoxiang reported that the clinical symptoms of invasion of other parts of the nervous system appeared on average 3 years after the onset of the first symptoms, and the degree of damage was compared: autonomic symptoms SDS >OPCA>SND, cerebellar symptoms OPCA >SDS>SND, extrapyramidal symptoms SND >SDS>OPCA, pyramidal tract signs SND SDS>OPCA, brainstem damage OPCA >SDS.

3.In addition to the complex compensatory mechanism, this separation phenomenon may also be related to the sloppiness of clinical examination or the lag of clinical manifestations behind pathological lesions.

In a group of 188 patients with pathologically confirmed MSA, 28% of the patients had four signs of cerebellum, extrapyramidal system, autonomic nervous system and pyramidal system. Another 29% of patients had three signs of Parkinsonism, autonomic impaired function, cerebellar sign or pyramidal tract sign; 11% of patients had parkinsonism and autonomic impairment; 10% of patients present with parkinsonism alone.

Hello, I'm glad I'm here with your question. First of all, let me give you a brief introduction to what cerebral atrophy is. Cerebral atrophy is a chronic degenerative disease of the central nervous system with cerebral or cerebellar ataxia and brainstem damage as the main clinical manifestations.

My aunt was also a brain atrophy patient, so I can understand your current distress. So, what exactly does brain atrophy affect patients? What are the precautions for patients in their daily lives?

Step Method:

1. As shown in the figure, the following figure is a schematic diagram of the basic structure of the brain, please see, there are many circuits in the brain, and it is these large and small circuits that make people think. After the brain shrinks, these circuits become fewer and smaller.

2. When this happens, the person has brain atrophy. So, what exactly are the symptoms of brain atrophy? After brain atrophy, people become sluggish, slurred speech, numb, child-like, and their IQ decreases.

3. After getting sick, it is recommended to go to the hospital as soon as possible for relevant diagnosis and **. The hospital will definitely provide you with the most suitable programs and measures. Thank you for taking time out of your busy schedule to ** my recovery, and I wish you a speedy recovery! Hope! Thank you!