How to prepare malonic acid? How to prepare diethyl malonate from acetic acid

It is synthesized from ethanol as raw material by ethyl acetoacetate.

It can be synthesized with malonic acid. The details are as follows: diethyl malonate + isopropyl bromide (reaction conditions: Etona, ETOH) to generate (CH3)2CHch2 (CO2ET)2 plus acid heating to generate 3-methylbutyric acid.

Methanol. Ethanol was used with SOCL2 to obtain the corresponding chlorinated hydrocarbons. In an alkaline environment, diethyl malonate is mixed with methyl chloride, respectively.

It reacts with monochloroethane, and then acidifies to obtain the corresponding carboxylic acid (disubstituted malonic acid), which is decarboxylated after slight heat to obtain the target product - methylbutyric acid.

Ethyl chloride. To prepare propionic acid, you can use a format to try a slurry such as a slip agent.

and carbon dioxide for preparation. It is also the most commonly used reaction to prepare more carboxylic oak equilibric acid.

First, ethyl chloride and magnesium are reacted to prepare the reagent for spring waxing. Then the prepared format reagent reacts with carbon dioxide, the reaction is completed, acidification, and distillation can obtain propionic acid. Reaction equations.

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Acetic acid is chlorinated under the catalysis of phosphorus to produce monochloroacetic acid.

Monochloroacetic acid is neutralized with sodium carbonate to produce a letter of sodium chloroacetate.

Sodium monochloroacetate reacts with cyanide (harmonious) Huazhou Bi potassium to form sodium cyanoacetate.

Sodium cyanoacetate is acidified to obtain cyanoacetic acid.

Under the catalysis of sulfuric acid, cyanoacetic acid reacts with ethanol to form diethyl malonic acid.

Is it the question of the Great Enlightenment Study Tour?

ch3cooh+h2---c2h5oh

CH3COOH+C2H5OH---CH3COOC2H5---CL2---CH2CLCoOC2H5---NACN--CH2CNCoOC2H5---HoocCH2CoOC2H5---C2H5OH---C2H5OOCch2CoOC2H5 (malonic acid quietly suppresses diethyl ester).

The synthetic route of propionic acid preparation from propylene mainly includes the following steps:

1.Oxidation of propylene dust: Propylene and air are oxidized in the presence of a catalyst to generate acrolein and malonic acid.

2.Selective hydrogenation: The resulting acrolein is selectively hydrogenated to obtain ethanol and ethylmalonic acid.

3.Dehydration: Ethylmalonic acid is dehydrated to produce isoglutarate (also known as methyllactic acid) as a colorless transparent liquid.

4.Oxidation: Partial or complete oxidation of isoglutarate to obtain the corresponding concentration of methyl emulsion, methyl hydroxyl emulsion or directly obtain pure succinic acid (i.e., n-pentatetracarbon).

These products can be used to prepare polystyrene, plastics and other materials. Among them, high-quality polycarbolin resin can be obtained by further reaction of methyl hydroxyl emulsion.

It should be noted that in practice, factors such as raw material purity, catalyst type and use conditions need to be considered, and corresponding measures should be taken to improve product quality and yield.

Summary. Hello, dear, according to the questions you provided, here we will find the following for you: The reaction equation for the preparation of butyric acid from 2-propanol is as follows:

CH3CH(OH)CH2OH + 2H2O + O2 ->CH3(CH2)3COOH + 2H2O This is an oxidation reaction that needs to be carried out under appropriate conditions. In general, the reaction needs to be carried out at high temperatures, high pressures, and in the presence of catalysts. The specific reaction conditions can be adjusted and changed according to the specific conditions of the laboratory.

The steps are as follows:12-propanol and water were added to the reaction kettle and heated to the reaction temperature.

2.Oxygen is added to trigger the reaction to start the reaction in the appropriate time. 3.

After a certain amount of time has elapsed, the reaction is stopped and the product is filtered. 4.The product was neutralized with sodium hydroxide solution.

5.The butyric acid precipitate is separated by centrifugation, and the pure product can be obtained after washing and drying. It should be noted that safety issues need to be paid attention to during the reaction process to avoid dangers such as ** and fire.

At the same time, the time and temperature of the reaction need to be controlled to obtain a high-purity product.

2-propanol to prepare butyric acid.

Hello, dear, according to the questions you provided, here we will find the following for you: The reaction equation for the preparation of butyric acid from 2-propanol is as follows: CH3CH(OH)CH2OH + 2H2O + O2 ->CH3(CH2)3COOH + 2H2O This is an oxidation reaction that needs to be carried out under appropriate conditions.

In general, the reaction needs to be carried out at high temperatures, high pressures, and in the presence of catalysts. The specific reaction conditions can be adjusted and changed according to the specific conditions of the laboratory. The steps are as follows:

1.2-propanol and water were added to the reaction kettle and heated to the reaction temperature. 2.

Oxygen is added to trigger the reaction, which begins at the appropriate time to start the reaction in the interlocal area. 3.After a certain amount of time has elapsed, the reaction is stopped and the product is filtered.

4.The product was neutralized with sodium hydroxide solution. 5.

The butyric acid precipitate is separated by centrifugation, and the pure product can be obtained after washing and drying. It should be noted that safety issues need to be paid attention to during the reaction process to avoid dangers such as ** and fire. At the same time, it is also necessary to control the time and temperature of the reaction to obtain a high-purity product.

To organic synthesis equations.

The formula for the preparation of butyric acid by 2-propanol is as follows: CH3CH(OH)CH2OH + 2H2O + O2 ->CH3(CH2)3COOH + 2H2O

1 Pinyin 2 English references.

3 annotation bǐng èr suān

malonic acid

Hocch2COOH malonic acid, similar in structure to succinic acid, can combine with succinate dehydrogenase to form a complex, becoming a diar-type dispersed nuclear inhibitor of this enzyme. Malonic acid has an inhibitory effect on the oxidation and respiration of fatty acids and sugars, because this effect stops the citric acid cycle. In nature, it is found in the fruit of apples and in the leaves of legumes.

Free malonic acid is an inhibitor of succinic acid as described above, and propyl coa-conjugated to CoA is an important precursor for fatty acid synthesis, and this compound is formed by the reaction of acetyl-CoA and HCO3 by acetyl-CoA carboxylase (EC6 4 1 2).

The malonate synthesis method is the synthesis of carboxylic acids.

Diethyl malonate is generally used.

for raw materials. First, diethyl malonate in sodium ethanol.

Under the action of hydrogen, the hydrogen is removed to obtain carboanions:

ch2(cooet)2 + c2h5ona → c2h5oh + nach(cooet)2

Ethanol is used as a solvent for this reaction. First, the sodium is dissolved in ethanol, then diethyl malonate is added, and it can be heated and boiled for a few minutes.

Nach(Cooet)2 is a strong nucleophile and can interact with halogenated hydrocarbons.

reaction, to get a hydrocarbon group.

Substituted diethyl malonate:

r-br + nach(cooet)2 → nabr↓ +r-ch(cooet)2

The resulting NABR is poorly soluble in ethanol, so it can be observed that the precipitation of white precipitation is manifested in Sakura.

This is an SN2 reaction.

Primary halogenated hydrocarbons and allyl halogenated hydrocarbons can obtain higher yields, while secondary halogenated hydrocarbons have low yields, so it is best not to use them; Tertiary halogenated hydrocarbons and haloethylene halogenated hydrocarbons cannot react smoothly.

Sodium hydroxide for R-CH (Cooet)2.

The solution is hydrolyzed, then acidified, and decarboxylated by adding sock plexus heat to obtain carboxylic acid:

r-ch(cooet)2 + 2naoh → r-ch(coona)2 + 2etoh

r-ch(coona)2 + 2hcl → r-ch(cooh)2 + 2nacl

R-CH(CoOH)2 R-CH2-CoOH + CO2 (reaction conditions are A-Dumb heating).

It is easy to see that the malonate synthesis method can obtain carboxylic acids with two more carbons than the original halogenated hydrocarbons.

In addition, the alkyl-substituted malonate ester R-CH(Cooet)2 still contains a reactive hydrogen group, which can be further alkyl group.

Chemistry: R-CH(Cooet)2+C2H5ONA(Cooet)2+C2H5OH

r-cna(cooet)2 + r`-br → rr`c(cooet)2 + nabr↓

RR C(Cooet)2 is hydrolyzed with a sodium hydroxide solution, then acidified, and heated to decarboxylation to obtain acetic acid with two alkyl group substitutions.