Difference Between Erythromycin and Azithromycin

Erythromycin is a new product, 1 time a day, and it is forbidden to take it under 12 years of age.

Azithromycin is an old product, 1 time a day, suitable for people of all ages.

Both belong to the same class of drugs.

But azithromycin is more effective, and it has been many years since profits have been squeezed out, so there are basically no rebates.

The efficacy of dierythromycin is much worse than that of azile, but it is much more expensive, and the rebate per box is more than 10 yuan.

They are all macrolides, which are a class of drugs, but geoerythromycin is a new drug, which is less toxic, has a stronger antibacterial effect, and of course it is more expensive, so it depends on your own choice.

Azithromycin is a new generation of macrolide antibiotics, which has stronger antimicrobial activity, a broader antibacterial spectrum, and fewer adverse reactions than erythromycin. Another extremely important feature is that azithromycin has a typical antimicrobial after-effect, which is related to its long blood half-life. Relevant data show that after oral or intravenous infusion of azithromycin, its blood half-life can be as long as 35 48 hours, so that azithromycin can still maintain the minimum effective inhibitory concentration within 72 hours of discontinuation.

This feature, on the one hand, makes it have a long-term effect, and only needs to take the drug once a day to achieve the same effect as erythromycin multiple times a day; On the other hand, it does not need to be administered continuously, and in recent years, in the clinical application of azithromycin**mycoplasma pneumonia and mycoplasma infectious diseases of the genitourinary tract, sequential ** is often adopted, that is, 3 days of administration, 4 days of drug withdrawal, and 3 days of further administration. In this way, taking the drug once a day and taking it for a short period of time can significantly increase the compliance of patients and significantly reduce the adverse reactions.

Thank you for the trouble to adopt!

Search: What is the difference between azithromycin and erythromycin?

1) Azithromycin expands the antibacterial range on the basis of erythromycin, and has a strong inhibitory effect on gram-positive bacteria such as Streptococcus pneumoniae and Haemophilus influenzae and Moraxella catarrhalis, both of which are the most common infections of the upper and lower respiratory tracts. After oral absorption, azithromycin quickly and extensively penetrates into human tissues, especially the lungs, bronchial mucosa, epithelial mucus and sputum, and preferentially distributes to the site of infection, which can effectively kill pathogenic microorganisms.

2) Azithromycin has a good post-antibiotic effect, oral administration for three days, antibacterial effect can be maintained for 10 days. After absorption, azithromycin is directly transmitted to the infected site or delivered through phagocytic cells, reaching a high tissue concentration at the lesion site, which can be 300 times higher than the extracellular concentration, and the tissue concentration decreases slowly.

3) It is stable to gastric acid, good oral absorption, and has few adverse reactions.

4) The half-life is prolonged, the medication time is less, and the tissue half-life is 68-76 hours. Due to the high tissue concentration and its ability to be maintained for a long time, only once a day dosing is sufficient. Erythromycin needs to be taken four times a day.

There is no absolute, each has its own pertinence, if you really need it, after providing details, I will help you make a preliminary judgment.

But the only way to do a drug susceptibility test is to do a drug susceptibility test.

Look at which antibiotic the bacteria are most sensitive to, and then use which antibiotic is the most effective.

Azithromycin belongs to the macrolide class of antibiotic columns. The antibacterial effect on various staphylococcus, streptococci and pneumococci is slightly worse than erythromycin, and enterococci are resistant to this product; However, the effect of this product on some gram-negative bacteria is stronger than erythromycin, such as the MIC of influenza bacilli including lactamase-producing strains is 8 times lower than that of erythromycin, about. The MIC against Moracatarrhal is , and the antimicrobial effect against peptococcus, peptic streptococcus, Bacteroides spp., and Bacteroides fragilis is similar or slightly worse than erythromycin.

The effect on intracellular pathogens such as mycoplasma, chlamydia, legionella, etc., is also similar to erythromycin.

Erythromycin is also a macrolide antibiotic, with an antibacterial spectrum similar to penicillin, and has a strong inhibitory effect on gram-positive bacteria, such as staphylococcus, Streptococcus pyogenes, Streptococcus greenis, Streptococcus pneumoniae, Streptococcus faecalis, Streptococcus hemolyticus, Clostridium, diphtheria, Bacillus anthracis, etc. It also has a certain inhibitory effect on gram-negative bacteria, such as gonorrhoea, spirobacteria, pertussis bacillus, brucella, Legionella, meningococcal and Haemophilus influenzae, bacteroides, some dysentery bacilli and Escherichia coli. In addition, it has inhibitory effect on mycoplasma, actinomycetes, spirochetes, rickettsia, chlamydia, Nocardia, a few mycobacteria and amoebic protozoa.

Staphylococcus and Streptococcus bacteria such as Staphylococcus aureus are easily resistant to the product.

It is characterized by penicillin-resistant strains and is sensitive to this product. The mechanism of action is mainly combined with the 50s subunit of ribonucleosomes, inhibiting peptidyl transferase, affecting the translocation process of ribonucleosomes, hindering the growth of peptide chains, inhibiting the synthesis of bacterial proteins, and being bacteriostatic agents.

Erythromycin belongs to the macrolide class of antibiotics and has antimicrobial activity against staphylococci spp., streptococci groups and gram-positive bacilli. Neisseria spp., Haemophilus influenzae, Bordetella pertussis, etc. can also be sensitive to this product. This product also has antibacterial activity against various anaerobic bacteria other than Bacteroides fragilis and Fusobacterium; It also has inhibitory effects on Legionella spp., Campylobacter foetus, some spirochetes, Mycoplasma pneumoniae, rickettsial spp., and Chlamydia spp.

This strain is a bacteriostatic agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site ("P" site), blocking the binding of transferred ribonucleic acid (T-RNA) to the "P" position, and also blocking the displacement of the polypeptide chain from the acceptor site ("A" position) to the "P" position, thus inhibiting bacterial protein synthesis.

Azithromycin also belongs to the macrolide class of antibiotics, and its antibacterial spectrum is similar to that of erythromycin, with a strong effect, and its effect on Haemophilus influenzae and gonorrhoea is 4 times stronger than that of erythromycin; 2 times stronger against Legionella; MIC 1 g ml against the vast majority of gram-negative bacteria also has a stronger effect on Clostridium than erythromycin, and is also more effective than erythromycin in the application of Staphylococcus aureus infections.