Basic information on ginsenoside Rg1

English name: ginsenoside rg1

Synonyms: Ginsenoside RG1

CAS Registry No. 22427-39-0

EINECS Accession Number 244-989-9

Purity: more than 98%, detection method HPLC.

Properties: Tetracyclic triterpenoid derivative. Crystalline powder (n-butanol-methyl ethyl ketone or ethyl formate).

Melting point 194, optical rotation +32 (pyridine). Optical rotation [ ]d+. Soluble in methanol, pyridine, hot acetone, slightly soluble in ethyl acetate and chloroform.

Its acetylate is soluble in methanol, pyridine, hot acetone, and slightly soluble in ethyl acetate and chloroform. Its acetylate is needle crystal, melting point 245.

Pharmacology: After intraperitoneal injection of 100mg kg, the DNA biosynthesis of bone marrow cells was significantly increased after 4 hours. There is a tendency to biosynthesize proteins or lipids in much the same way as to biosynthetic effects on DNA; It can reduce the contraction of the isolated uterus of guinea pigs caused by acylcholine; It has the effect of slowing down heart rate and bidirectional blood pressure in rats (first rising and then falling); It has a vasodilating and anti-fatigue effect.

The effect depends on personal absorption, it is difficult to find ginsenoside rg3 with high content, most of them are ginseng powder or ginsenoside powder instead, if you want to find **, go to the State Food and Drug Administration** to check the authenticity of the ingredients, and the content. Check one and one accurate. Don't be fooled.

The effect is there, but what's going on now?

Product name】 Ginsenoside RE

Nickname in English] panaxoside

CAS Number] 52286-59-6

Detection method] HPLC 98%.

Specification: 5mg 10mg 20mg 50mg 100mg 500mg 1g (can be packed according to customer needs).

Identification methods: liquid chromatography (HPLC), mass spectrometry (mass), nuclear magnetic resonance (NMR).

Density] boiling point] at 760 mmHg

Melting Point] 201 203

Flash Point] Usage] Chromatographic conditions: acetonitrile: phosphoric acid solution = 22:

78；Detection mode: 203nm, column temperature: 30.

Function and use] This product is used for content determination, identification, pharmacological experiments, activity screening, etc.

Precautions】 This product should be stored at low temperature, and the content will be reduced when exposed to air for a long time.

Production unit] Chengdu Pufield Biotechnology****.

Quality commitment] For product quality problems that are not caused by man, our company is responsible for returning or replacing the goods (not artificially caused by the purchaser).

Warm reminder] All products provided by our company are only for scientific research and laboratory use, and shall not be used for injection, food or other purposes.

Ginsenoside RE is a tetracyclic triterpenoid derivative with colorless needle-like crystals.

Chinese name: ginsenoside re

Chinese aliases: ginsenoside re, ginsenoside B2

English name: ginsenoside re

CAS Number] 52286-59-6

MF: C48H82O18

Molecular weight: Purity: HPLC 98%.

Appearance: White powder.

Answer]: B This question is the structural type of saponin and its common compounds. Among the alternative answers, only option A is the steroidal sensitive saponin structure type, the rest are triterpene saponin structure type, B option is the tetracyclic triterpenoid structure type, and C, D, and E options are the pentacyclic triterpene structure type.

Ginselenosaponin is a dammarane-type tetracyclic triterpene saponin.

We all know ginsenosides.

RG3 has strong antitumor pharmacological effects, but it is only a component that is insoluble in lipid and water, and hydrolysis may occur in the acidic environment of gastric juice, and bioavailability.

Only. Because it is insoluble in water, it is difficult to be absorbed by the gastrointestinal mucosa, which severely limits the role of ginsenoside RG3 in the human body.

To put it simply, non-water-soluble ginsenoside RG3 mainly exists in the form of large-particle size flake crystals, and the crystal surface is different from the internal structure of the crystal, which accumulates earlier than the surface foci.

Small and not easily dissolvable. However, the crystal flake drug structure of ginsenoside Rg3 made by water-soluble preparation process disappeared and appeared in a loose and porous form, with an increase in specific surface area and solubility.

Significant increase and good stability.

Therefore, in order to fully exert its effect in the human body, it is necessary to increase the absorption rate and convert non-water-soluble RG3 into water-soluble RG3. After several years of research, Chinese pharmacist Dr. R&F and his team have creatively invented a preparation process that can enrich and obtain water-soluble ginsenoside monomers in large quantities.

The water-soluble G35 composition is to modulate the ratio of RG3 and RG5 through this technology, and form a unique water-soluble composition through the preparation process of water-soluble ginsenosides.

We all know that the traditional single-component ginsenoside RG3 can promote the apoptosis of cancer cells, inhibit the growth and proliferation of tumor cells, and enhance natural killer cells by fighting cancer cell infiltration and metastasis.

and interleukin 2 activity, improve the body's immune function and other mechanisms to play a curative effect, but there is one point, the absorption rate is not good. The ginsenoside G35 composition is to dissolve the ordinary ginsenoside RG3 to upgrade to water-soluble ginsenoside RG3, you must know that the water-soluble ginsenoside hidden finch can be fully dissolved through the stomach and intestines, and the absorption rate is significantly improved, at present, the technology has successfully applied for patent certification in 15 countries, and China's scientific research and technology is once again at the forefront of technology at home and abroad!

In addition, the results of scientific research experiments have shown that the solubility of water-soluble ginsenoside Rg3 is about twice that of non-water-soluble ginsenoside Rg3 after entering the human stomach and intestines [9], which significantly improves its bioavailability in the human body and greatly improves its efficacy in the human body. It is also said that the G35 composition is compared to the traditional monomeric saponin composition for cancer.

The anti-tumor effect is stronger in patients.

Ginsenoside RG3 is extracted in trace amounts from red ginseng (cultivated ginseng is made by drying or drying and then steaming), and contains only 3/100,000 in red ginseng for more than 5 years, which is the most essential ingredient in ginseng. If RG3 is removed from ginseng, human participation in radish is not much different. It is difficult to extract high-purity RG3 from such a low content with conventional techniques.

Therefore, RG3 is really more precious than diamonds, and RG3 with 95% purity sells for $50,000 per gram. Purification of RG3 requires 6-year-old, high-quality ginseng, while it takes 20-30 years for the mountains to return to a state where crops and trees can grow normally after planting ginseng. Ginseng raw material ** has a higher value.

Friends who know RG3 capsule ginseng Baiyi know that the main ingredient of the capsule is ginsenoside RG3, which is a rare and precious saponin in ginseng, and the content in ginseng is only 3/100,000. For example, the ginsenoside RG3 component in a bottle of ginseng Baiyi capsule can catch up with the content of several high-quality Changbai Mountain ginseng.

On the international market, a milligram of high-purity RG3 is worth $300 in public trade, which is more than that of a "diamond". Chroma DEX Inc.**RG3 (purity 95%) standard, priced at $50 mg; Converted, each gram of RG3 reaches 50,000 US dollars;

Health foods containing RG3 are priced at 1.5 million won in South Korea for 396 capsules (each containing only 1 mg of RG3), which is equivalent to 9,500 yuan mg. And the normal **** is stable at around 400 yuan grams, compared with the value of RG3 goods of 60,000 US dollars, it is really a world of difference!

Because the extraction and preparation process of RG3 is extremely complex, it is particularly expensive in the world. Because Fusheng Pharmaceutical Co., Ltd. has achieved a breakthrough in industrial production technology, the price has been kept low on the basis of ensuring purity and efficacy, and for the purpose of benefiting the public. "In the old days, Wang Xie Tang Qianyan flew into the homes of ordinary people", and more and more ordinary people have been able to accept RG3's health care.

It is supposed to be extracted from ginseng.

Categories: Medical, Diseases, >> Medicines.

Problem description: I don't really understand what it is, it seems that it can cure tumors or something.

But no matter what, friends who know ginsenosides can leave a word.

Thank you very much for your advice...

Analysis: Ginseng is a perennial herb of the family Panaxaceae, which has a long history of medicinal use in China and is a valuable Chinese medicinal material. According to the chemical analysis of modern medicine, ginseng contains a variety of components, including organic acids, vitamins, sugars, inorganic salts, sterols, oligopeptides, polysaccharides, volatile oils and ginsenosides.

Studies have shown that the main medicinal active ingredients of ginseng are ginsenosides and ginseng polysaccharides, which have strong activity in cancer prevention and **.

Ginsenoside-RH2 and RG3 are tetracyclic triterpenoids with anticancer activity isolated from ginseng. Among them, the new anti-cancer drug RG3 ginseng-capsule with ginsenosides as the main ingredient has been awarded the first-class new drug certificate of traditional Chinese medicine issued by the State Drug Administration.

Tetracyclic triterpenoids are the basic structure of the parent nucleus, and multiple glucose molecules are attached to the parent nucleus to become saponins. One or more hydroxyl groups can also be attached to the parent nucleus to form various structures, and names such as ginsenoside rh2 and ginsenoside rg3 can be obtained according to the different names of the specific disordered mold structure.

You can consult a professional for details.

There are too many specific materials, and the number of articles published on ginseng research data may be the largest in the category of traditional Chinese medicine, and it is impossible to enumerate. You can look it up in the library. For a preliminary understanding, you can take a look at the review articles.