Skin test for cephalosporin allergy but I have been fine with cephalosporins before, can I continue

Cephalosporins and penicillins are cousins in terms of chemical structure and pharmacological mechanism, but they are different in the matter of allergies. The cause of penicillin antimicrobial drug allergy is very clear, mainly penicillin-thiazole and penicillenic acid, so it has clear skin test requirements and skin test methods. However, the hapten determinants caused by cephalosporins have not yet been understood, which may be the components of the API or other impurities in the production and storage process, so there is no unified skin test requirements and skin test standards.

In most countries in Europe and the United States, skin tests are not done, but in Japan and some countries in Northern Europe, skin tests are required. At present, there is no clear requirement in China on this point, and each hospital may have its own different system norms. Because the coincidence rate of the skin test is less than 30%, the false positive of the skin test may make the ** selection less, and the false negative makes the medical personnel lose vigilance.

In short, it's very disturbing. Perhaps out of defensiveness, many doctors are still very willing to let the patient do a cephalosporin test, and they always feel uneasy not to do it. However, as mentioned earlier, under the premise that the allergenic ingredients are not clear, even if the skin test is done, the skin test should be done with the stock solution.

However, many medical institutions use cefazolin for skin testing, which is even less convincing. In addition, there are problems in the type, concentration, dosage, preparation and storage methods of the skin test solution, and the inconsistency of these elements makes the positive rate of the skin test vary greatly (10-50%). So, back to the subject's question, it is not easy to say whether your skin test method is standardized and whether the positive result is reliable.

Even reliable results do not mean that you are collectively allergic to cephalosporins and should not be taken in the future. Therefore, if you must use this type of drug, you can take the drug for the first time in a qualified medical institution and stay for observation, and if you are not unwell, you can continue to take the drug with confidence. As for whether to do a skin test every time you take a drug, you can let the doctor make a comprehensive judgment based on your physique, allergy history, and disease conditions.

Copied from someone else, I hope it will help you.

Cephalosporins, including penicillins, are the most effective and smallest antibiotics, and their biggest disadvantage is that they are prone to allergic reactions. Moreover, allergic reactions are likely to be very serious and even life-threatening, so a skin test must be carried out before use. A skin test is a very small dose of a drug injected under the skin to see if the patient is a good candidate for the drug.

But there will also be some people who have an allergic reaction that is not obvious in this small dose, and in the intravenous infusion process, the dose is very large, and then your allergic reaction will occur.

In fact, for people who know some medical knowledge, they know that the abuse of antibiotics in China is very serious, and many patients do not need to use drugs at all, and patients do take the initiative to ask for two injections, which may not necessarily be able to accelerate your **. However, due to the regular use of antibiotics, the bacteria are becoming more and more resistant, which is not conducive to the future medication of the patients themselves.

Especially in the case of China's immature pharmaceutical industry, drug production cannot be absolutely safe, and the vast majority of accidents are caused by infusion. You can imagine how dangerous it is to inject that bottle of infusion directly into your bloodstream, not just into your stomach.

According to your understanding, if you use it once and are not allergic, it means that you will not be allergic?

In fact, cephalosporins are divided into three generations, and there are many species in each generation, and not every doctor will prescribe you a cephalosporin. And even if it is the same kind and from different manufacturers, it may be possible that you are not allergic last time, and you will be allergic this time. This can happen even if it is from the same manufacturer and in different batches.

Therefore, before each use of cephalosporin, the doctor requires a skin test.

Generally there is no problem. However, there are also delayed reaction allergies, and delayed reaction anaphylactic shock.

The state stipulates that it is required, and it must be skin tested! It's just that the implementation is not good at all now.

For example, if you go to the pharmacy to buy prescription drugs, you must have a prescription according to the regulations, but which pharmacy is there to read the prescription?

The latest textbook for nursing undergraduates, the fifth edition of "Basic Nursing", P362, has clear provisions - matching ideas - cephalosporins.

Allergy test method:

Cephalosporins are a class of high-potency, low-toxicity, broad-spectrum antibiotics that can cause allergic reactions.

Therefore, it is necessary to do an allergy test before taking the drug. In addition, cephalosporins and penicillins should be noted.

About 10% to 30% of people who are allergic to penicillin are allergic to cephalosporins, and the vast majority of people who are allergic to cephalosporins are allergic to penicillin.

Whether injected or oral, cephalosporins must be tested according to regulations.

Disease analysis: Amoxicillin capsule is a penicillin capsule, and cephalosporin and penicillin are the same drugs. There is a cross-allergy between the two drugs, and there is also a possibility of late-onset allergy to penicillin, which is also not guaranteed to be safe in the case of a negative skin test.

Suggestion: The talker suggested switching to other anti-inflammatory drugs.

Amoxicillin belongs to the penicillin class of anti-alassantin; Cephalexin is a cephalosporin antibiotic. They all belong to the -lactam class of antibiotics!

There is a certain cross-allergy between penicillin antibiotics and cephalosporin antibiotics, and if you are allergic to one of the antibiotics, it is best to avoid taking the other antibiotic! and bridge raids.

Choose other types of antibiotics**!

Analysis: Hello, cephalosporin allergy cannot take cephalosporin drugs, and cephalosporin allergy will also cause serious moral harm to patients, and even harm to life.

Suggestions: It is suggested that children are not allergic to cephalosporin, but with the change of physical constitution or the external environment, it may cause cephalosporin allergy. I wish you good health.

1. It cannot be determined, the two drugs are both betalactam drugs, which are cross-allergies, and their allergies are related to the content of allergic components (an impurity in preparation) and individual sensitivity. 2. Suggestion: use laryngeal disease, with lymphadenopathy azithromycin.

Cephalosporin allergy does not mean penicillin allergy. The two are just cross-allergies.

I'm allergic to cefuroxime. I did a skin test. But I didn't have any problems taking amoxicillin.

No, slow Yan Shu Ning, or cididine.

You'd better consult a doctor about this and don't take medicine indiscriminately.