What does elevated aminotransferase mean?

Elevated aminotransferases are a common phenomenon and do not necessarily mean that there is a problem with the liver. Because aminotransferases are very sensitive, many factors can cause transaminases to fluctuate up and down, and the results of transaminase measurements may vary depending on the time of day in healthy people.

Elevated aminotransferases can be broadly divided into three grades:

1. Those less than 120 IU L are called mild aminotransferase elevation;

Between 400 IU L is called moderately elevated aminotransferases;

3. More than 400 IU L is called severe transaminase elevation.

If the aminotransferase is outside the normal range, the doctor will recommend another retest, but even if it is high, the condition cannot be judged simply by the degree of elevated aminotransferase, and the degree of liver damage should be determined by combining other indicators that reflect liver function (such as serum bilirubin, cholinesterase, albumin, etc.) and the results of hepatobiliary and spleen ultrasound examination.

It's just that the liver function is not normal!

Sichuan West China Institute of Liver Diseases-Department of Hepatology-Deputy Chief Physician-Li Hui-What is the cause of elevated aminotransferases?

There are signs of damage to the cells of the liver, and the aminotransferases in the cells have escaped....So aminotransferases are high.

Overall, it's possible to develop hepatitis B.

Elevated aminotransferases [1] are a very common condition and do not necessarily have a problem with the liver. Because aminotransferases are very sensitive, many factors can cause normal transaminase values to fluctuate up and down, and the results of transaminase measurements may vary depending on the time of day in healthy people.

Aminotransferases are essential "catalysts" in the body's metabolic processes and are mainly found in liver cells. When liver cells are damaged, such as inflammation, necrosis, poisoning, etc., transaminases will be released into the blood, resulting in an increase in serum aminotransferases. Typically, the main aminotransferase to be checked in a physical exam is alanine aminotransferase (ALT).

1% liver cell damage can increase the concentration of ALT in the blood by a factor of 1. Therefore, ALT levels can be more sensitive to detect whether the liver is damaged.

1.It is recommended to go to a local professional hospital for treatment, alanine aminotransferase is the most sensitive indicator to reflect the degree of damage to liver cells, when liver cells are damaged, necrosis, poisoning, etc., alanine aminotransferase is released into the blood, which will cause high serum aminotransferase. High aminotransferases usually mean liver damage, and for patients with liver disease, it means liver disease**, so patients with liver disease are most afraid of high aminotransferases.

2.Patients with high aminotransferases must pay attention to their diet in addition to being targeted.

The causes of high aminotransferases are as follows.

1. Liver diseases, especially various types of viral hepatitis B, cirrhosis, liver abscess, liver tuberculosis, liver cirrhosis, steatohepatitis, Wilson's disease, etc., can be the cause of high transaminases.

2. In addition to the liver, other organs and tissues of the body also carry this enzyme, so when myocarditis, pyelonephritis, lobar pneumonia, tuberculosis, Japanese encephalitis, common myositis, acute sepsis, enteric typhoid, encephalopathy, malaria, cholecystitis, leptospirosis, influenza, measles, schistosomiasis, crush syndrome, etc., high transaminases in the blood can also be seen.

3. Since transaminases are excreted from the bile ducts, if there are diseases of the bile ducts, gallbladder and pancreas, and bile ducts are blocked, the transaminases can also be high.

4. When liver cirrhosis and liver cancer cirrhosis are active, alanine aminotransferase can usually be high, and it should be active.

5. When the biliary tract disease cholecystitis and cholelithiasis are attacked, there are often fever, abdominal pain, nausea, vomiting, jaundice, high blood total bilirubin and alanine aminotransferase.

6. In the case of acute myocardial infarction, myocarditis and heart failure in heart disease, alanine aminotransferase and aspartate aminotransferase are high, and hepatitis B patients often have chest pain, palpitations, shortness of breath and edema. Cardiac tests show positive signs and ECG variants.

7. In addition, some infectious diseases, such as pneumonia, typhoid, tuberculosis, infectious monocyte enlargement, etc., have high alanine aminotransferase.

If the aminotransferases are high, do not worry too much, but also look at other test results, as well as the current symptoms, and go to a regular hospital for detailed consultation and treatment.

High aminotransferases are thought to be due to diseases of the hepatobiliary system. Drug-induced hepatitis will also cause an increase in transaminases, commonly anti-tuberculosis drugs, and liver damage will occur after a long period of medication. In addition, there are chronic diseases, such as diseases of the liver and kidney system, heart diseases, high blood pressure, etc., and chronic liver damage will also occur with long-term medication.

Obstruction, stones, and tumors of the biliary system will lead to cholestasis, and secondary infections will also cause a decrease in liver function, an increase in bilirubin and abnormal transaminases, and patients will have pain, fatigue, fever, nausea, and vomiting in the liver area. In severe cases, jaundice will also occur, and it should be actively carried out in the early stage** to relieve obstruction and control infection. For chronic liver disease, we should actively protect the liver**, stay away from the environment of smoking and alcohol, stop drugs that cause liver damage, and have regular liver function tests and examinations.

Also, pay attention to your diet.

Aminotransferase is an indicator in liver function testing, and high aminotransferase index indicates the possibility of impaired liver function, and physiological reasons include excessive fatigue, drinking, strenuous exercise, etc. Pathological causes include hepatitis, liver cirrhosis, autoimmune liver disease, etc., and the specific ** needs to be judged in combination with clinical symptoms.

Considering that liver function is damaged, alanine aminotransferase and aspartate aminotransferase are two very important enzymes that represent liver function, and there are many reasons for liver function damage, such as alcohol, drugs, metabolism, viruses, etc., and fatty liver can also cause damage, and transaminases cannot be quickly reduced.

High aminotransferases mainly refer to alanine aminotransferase and aspartate aminotransferase, which are mainly indicators of hepatocyte damage. If you drink alcohol, catch a cold, or take other medications 1-2 days before the physical examination, it may cause high aminotransferases, but generally not too much. If these factors are removed, the aminotransferases are normal, and there is no need for **, only a re-examination is required.

But there are some that are indeed caused by chronic hepatitis, such as chronic hepatitis B, hepatitis C, alcoholic hepatitis, steatohepatitis, autoimmune hepatitis, etc., this aminotransferase will not drop to normal if it is not **, and will occur repeatedly.