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Hello! Chronic complications caused by diabetes mellitus can spread to all important organs of the body, and the pathogenesis is very complex, so it can be said that it has not been fully elucidated, and the current medical community believes that it is related to the interaction of genetic predisposition, insulin resistance, hyperglycemia, oxidative stress and other factors. Oxidative stress caused by hyperglycemia is an important common mechanism, which further causes activation of the polyol pathway, non-enzymatic glycation, protein kinase C, and hexosamine pathway, leading to tissue damage.
In addition, the relevant factors directly or indirectly involved in the occurrence and development of various chronic complications include abnormal levels of various hormones such as insulin, sex hormones, growth hormone, catecholamines, abnormal lipid metabolism, and changes in endocrine and paracrine functions of fat cells; Low-grade inflammatory state, vascular endothelial cell dysfunction, abnormal activity of the fibrinolytic system of blood coagulant, etc. Among them, most diabetic patients die from cardiac or cerebrovascular complications or diabetic nephropathy.
Diabetic nephropathy is mainly a microangiopathy, with typical changes including microcirculation disorders and microvascular basement membrane thickening, and the mechanism is extremely complex, and it is related to intracellular signal transduction, abnormal regulation of extracellular signaling molecules, and systemic metabolic factors. The basic pathological features of diabetic nephropathy are uniform hypertrophy of the glomerular basement membrane accompanied by increased glomerular mesangial cell stroma, nodular hypertrophy and increased permeability of glomerular sacs and mesangial cells.
Hope mine helps you!
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To put it simply. Because of high blood sugar, the organs of the whole body are like soaking in sugar water, so they can be damaged.
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Diabetes is a disease of the endocrine system, metabolic disorders, and will cause cardio-cerebral and renal complications, and in the end it is a road of no return! If you have high blood sugar, be sure to take medication as soon as possible!
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High blood sugar indicates that the patient has diabetes, and long-term diabetes may lead to renal arteriosclerosis and renal ischemia, so that growth function gradually declines, leading to diabetic nephropathy, so high blood sugar will affect the kidneys. If diabetes is confirmed, it is necessary to go to the diagnosis and treatment in time, adhere to blood sugar control, pay attention to kidney function review, pay attention to rest, and protect kidney function. A more scientific mushroom therapy system is gradually approaching everyone's field of vision, which can be matched with Xiangling mushroom powder, which is composed of white mushrooms, straw mushrooms, shiitake mushrooms and cordyceps, which is extracted from natural medicinal and edible homologous plants, which can lower blood sugar without hurting the kidneys or increasing the burden on the liver, and solve the disadvantages of Chinese and Western medicine to lower blood sugar but hurt the body.
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In general, there is no direct link between nephritis and high blood sugar, and nephritis generally does not cause the patient's blood sugar to rise.
The regulation of blood sugar mainly depends on insulin, insulin is the only hormone in our body that can lower blood sugar, this hormone is produced by pancreatic islet cells, high blood sugar is often because pancreatic islet cells do not secrete enough insulin, or the ability of insulin to act, sensitivity decreases, and nephritis does not cause damage to pancreatic islets, nor does it cause a decrease in insulin sensitivity. So generally speaking, nephritis does not cause blood sugar to rise, of course, if glucocorticoids are used for nephritis**, hormones may raise the patient's blood sugar. Conversely, diabetic patients may damage the glomeruli over time, causing proteinuria.
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Kidney disease does not usually cause an increase in blood sugar, but diabetes can cause kidney disease. It is also possible that kidney disease and elevated blood sugar are two separate disorders. Diabetes mellitus may have no typical symptoms, or symptoms of polydipsia, polyphagia, polyuria, and weight loss may occur, and diabetes mellitus can be diagnosed when the normal fasting blood glucose is between two different times, and the fasting blood glucose is greater than mmol L at two different times or the postprandial blood glucose is greater than mmol L.
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It depends on what medicine you take, if you take Sangtang Drink Oral Liquid, it will definitely not hurt your kidneys.
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Generally, no.
There are many reasons for high blood sugar, and there are five main aspects:
Excessive obesity, now that the standard of living is improving, many people cannot control their diet well, and obesity may raise blood sugar.
Drinking alcohol can cause high blood sugar. Drinking alcohol reduces the diet, but alcohol is absorbed and metabolized more quickly and cannot maintain blood sugar levels for a longer period of time, so it can lead to high blood sugar.
Excessive intake, especially sweets or sugary drinks, makes the sugar content in the human body significantly higher than the standard requirement, resulting in high blood sugar.
Excessive emotional or mental stress, emotional ups and downs that fluctuate too much, may make some organs function abnormally, disorder the internal environment of the building, and raise blood sugar.
Something is wrong with metabolic function. This is most likely diabetes.
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Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar. Hyperglycemia is caused by a defect in insulin secretion, impaired biological action, or both. The long-standing hyperglycemia in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves.
The diagnosis of diabetes mellitus is generally not difficult, and the diagnosis can be confirmed by fasting blood glucose greater than or equal to millimol liters, or blood glucose greater than or equal to millimolar liters two hours after a meal. Classification is done after the diagnosis of diabetes:
1 Type 1 diabetes.
The age of onset is young, most of them are < 30 years old, the onset is sudden, the symptoms of polydipsia, polyuria, polyphagia and weight loss are obvious, the blood sugar level is high, many patients have ketoacidosis as the first symptom, the serum insulin and C peptide levels are low, and ICA, IAA or GAD antibodies can be positive. Oral drugs alone are ineffective and require insulin**.
2 Type 2 diabetes.
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Hello: Diabetic nephropathy is the leading complication of diabetes, which damages various organs of the kidneys. Controlling blood sugar is key to preventing complications.
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The pathogenesis of diabetic nephropathy, like other diabetic microvascular complications, has not been fully elucidated, and it has been mentioned that not every diabetic patient will develop diabetic nephropathy, therefore, people mainly look for risk factors for the development of diabetic nephropathy, and the currently known risk factors are briefly described below. 1.Renal hemodynamic abnormalities, which play a key role in the development of diabetic nephropathy and may even be the initiating factor.
In addition, diabetic patients are accompanied by hypertension, which can significantly accelerate the onset and progression of diabetic nephropathy. 2.Glycation end products are formed, and long-term hyperglycemia leads to increased glycation end product production, which can cause changes in the quality and quantity of extracellular matrices, such as collagen, laminin and vitreous binding proteins, and excessive matrix production.
In the kidneys, glomeruli can synthesize collagen, endothelium, mesangial and smooth muscle cells to proliferate. 3.Genetic factors, it has been found that T1DM siblings with diabetic nephropathy have a significantly higher incidence of diabetic nephropathy once they develop diabetes.
Diabetic patients with a family history of essential hypertension have an increased risk of developing kidney disease, which has been found to be three times higher, indicating a familial cluster of diabetic nephropathy. However, some patients do not develop diabetic nephropathy for a long time with diabetes, which also suggests that diabetic nephropathy has a certain relationship with genetics. In summary, the mechanism of diabetic nephropathy is complex and involves a variety of factors.
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Good question, simply put, diabetes is a disease that mainly affects the kidneys. "Why is the damage to kidney disease serious" means that you don't know about diabetes yet. Look up what diabetes is online.
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