Is there a relationship between olfactory dysfunction and Parkinson s disease?

The main clinical manifestations of Parkinson's are: 1. The main motor symptoms caused by the decrease in dopaminergic neurons 50: decreased movement or akinesia, stiffness, resting tremor, and postural balance disorders.

2. Non-motor symptoms caused by non-dopaminergic neurons (cholinergic, adrenergic, pentamenergic, glutamatergic). 1) Mental: depression, anxiety, cognitive impairment, hallucinations, apathy, sleep disturbances (poor sleep quality at night, daytime sleepiness).

2) Autonomic nervous system: constipation, low blood pressure, hyperhidrosis, sexual dysfunction, urination disorder, salivation. 3) Sensory impairment:

Numbness, pain, cramping, restless legs syndrome, olfactory disturbances.

Not necessarily. There are many reasons for poor sense of smell, and it is best to go to a tertiary hospital to find a doctor and then treat the symptoms**.

At present, the mechanism of olfactory impairment in patients with Parkinson's disease is not well understood. Olfactory impairment in Parkinson's disease may have little to do with damage to dopaminergic neurons. There are two main views on the mechanism of olfactory disorder in patients with Parkinson's disease, one is the peripheral mechanism, that is, the olfactory pathway is first damaged, causing the ** child to enter the brain tissue through the olfactory mucosa and olfactory nerve, and then causing damage to the substantia nigra of the midbrain, resulting in Parkinson's disease symptoms.

Hallucinations in Parkinson's disease tend to occur at one stage of the disease. Therefore, after the patient has hallucinations to ZD, he should first distinguish whether it is caused by the drug or the disease itself. Because there are a variety of drugs involved in the process of Parkinson's disease, some drugs have an effect on the appearance of hallucinations in Parkinson's disease.

At this time, first analyze what drugs the patient uses, such as amantadine, ampantan, etc., which will affect the patient's hallucinations, and gradually reduce the dose of drugs that are easy to induce hallucinations, and try to adjust the drugs to see if the hallucinations can be reduced. If there is no significant improvement in this case, try to change the dose of medopa, and if the dose is slightly reduced, the patient's hallucinations will improve, without affecting Parkinson's disease**. If the patient's hallucinations do not improve with medication adjustments, antipsychotics, atypical antipsychotics, such as quetiapine, may be used.

However, an atypical antipsychotic called olanzapine cannot be used and is not recommended in patients with Parkinson's. There is also a category of cholinesterase inhibitors, donepezil and the like that can be used, which can improve both cognition and hallucinations. Therefore, for hallucinations in Parkinson's disease, first distinguish whether it is drug-induced, and then carry out the corresponding **.

Olfactory dysfunction is not necessarily a precursor to Parkinson's disease, first of all, olfactory dysfunction may be due to lung disease or neuropathic, factors, and the recommendations should be clear and specific first**Carry out related ** usually pay more attention to rest, do not have too much psychological shadow.

Olfactory dysfunction, he may be a more common symptom of Parkinson's, it may be Parkinson's caused by olfactory blindness, but Parkinson's patients have anosmia in the early stage, and his specific ** is not particularly clear.

Hyposmia is a very important non-motor symptom of Parkinson's disease and can occur at different stages of the disease. Many people with Parkinson's disease have a reduced sense of smell before they develop tremors in their hands and feet. Because the loss of smell has little impact on daily life, it can be easily overlooked.

Mild loss of smell is manifested by insensitivity to some pungent smells, such as stir-frying chili peppers and chopping onions, which are felt by people around them, but not by people with Parkinson's disease. Severe loss of smell The patient cannot distinguish the smell of food, cannot smell the fragrance of flowers and plants, and does not feel all the smells. Some patients forgot to turn off the gas because they were cooking, and the family members smelled the leaked gas, and then they found that the patient's sense of smell was reduced.

Hyposmia is not a symptom specific to Parkinson's disease and can also be seen in other diseases such as rhinitis and head trauma. If the elderly find that their sense of smell is not very sensitive, they should be vigilant, and if they find that their hands and feet are a little shaky or inflexible, they should seek medical attention in time.

Olfactory disturbances in Parkinson's patients may occur for the following reasons:

1. It is related to the patient's mental factors, and the patient's mood fluctuations are a major cause of his olfactory disorder;

2. Other reasons are related to the patient's cognitive dysfunction, because Parkinson's disease will affect the patient's cognitive function, cognitive dysfunction will also affect the patient's sense of smell judgment, and there will be anosmia. After clarifying Parkinson's **, according to ****. Parkinson's disease, also known as parkinson's paralysis, is a degenerative disease of the nervous system, more common in middle-aged and elderly patients, Parkinson's is more complex, can be seen in infection, trauma or cerebrovascular disease, brain atrophy caused, some patients also have a certain relationship with external factors, environment and age.

The main symptoms of patients are resting tremor, bradykinesia, muscle rigidity, and in severe cases, inability to walk and self-care. Since Parkinson's is a chronic disease, so far, there is no best way, but it can eliminate the patient's **, give symptomatic **, most of the application of medopa, by increasing the dopamine in the body, improve the patient's symptoms, and at the same time give drugs to nourish brain cells, and usually strengthen the care of the patient to prevent falls and complications.

In the early stage of Parkinson's disease, patients will have a hyposmia, mainly due to the deposition of abnormal substances in the brain in the nerve nucleus responsible for the sense of smell, and the patients will have olfactory disorders, and some patients will not be obvious, and can only be detected when other symptoms appear. Due to the deposition of abnormal substances in the brain, causing a series of symptoms of the experimental system, then when these abnormal substances are deposited in the nerve nucleus responsible for the sense of smell, the sense of smell in our brain, and the location of the olfactory place, the patient will have olfactory disorders, some patients may not be very sensitive to olfactory disorders, only when there are some motor symptoms, then in tracing the patient's medical history, the patient may recall that he has olfactory disorders, but there are some cases, the patient is in the early stage of the diseaseIn this case, many patients will regard olfactory disorder as some rhinitis or some local nasal problems, and in fact, hyposmia may be one of the early manifestations and forms of Parkinson's disease.

Hyposmia is a common non-motor symptom in patients with Parkinson's disease, occurring in 50-90% of patients. The main manifestations are anomalous olfactory discrimination, olfactory recognition, and olfactory thresholds. However, the degree of damage varies from one area to another, meaning that each person with Parkinson's disease may have a different sense of smell impairment.

Loss of smell in people with Parkinson's disease often occurs early in the disease, even years before motor symptoms.