What is the disease of the red class wolf, and what is the cause of the red class wolf

Lupus erythematosus (SLE) is an autoimmune disease that affects multiple systems and organs of the body, with complex clinical manifestations and repeated disease course. Lupus erythematosus can be divided into two main categories: systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE). Subacute lupus erythematosus (SCLE) is a lesion that sits between discoid lupus erythematosus and systemic lupus erythematosus.

When it comes to lupus erythematosus, many people know that it is an autoimmune disease, but if you ask about the origin of the word lupus erythematosus, I am afraid that not everyone can explain it clearly. There is never a similar name in the vast number of TCM books, but there are some scattered descriptions of the symptoms of lupus erythematosus. Lupus erythematosus symptoms.

The word lupus comes from Latin and has been used in Western medicine since around the 19th century. But it wasn't until the middle of the 19th century that a doctor named Kasenlaf officially used it"Lupus erythematosus"This is a medical term. However, the lupus erythematosus he refers to only refers to discoid lupus erythematosus, which is mainly damaged.

People have seen people with this disease repeatedly have stubborn and intractable ** damage on the face or other related parts, and some also have atrophy, scarring, plain color changes on the basis of erythema, etc., which makes the face deformed, severely disfigured, and looks like it has been bitten by a wolf, so it has its name. Later, with the continuous development of medical science, people's understanding of lupus erythematosus gradually deepened, so the name systemic lupus erythematosus was proposed. In addition to the typical ** damage, systemic lupus erythematosus also includes damage to various systems and organs of the body, such as kidneys, heart, liver, brain, lungs, etc.

Lupus erythematosus has a steady onset or abrupt onset, the onset is more dangerous, and it is very easy, prolonged, and impermanent, just as cunning as a wolf. In addition to the typical discoid erythema in discoid lupus erythematosus, patients with systemic lupus erythematosus also have butterfly erythema, erythema multiforme, annular erythema, bullous erythema, and some also have discoid erythema, so the name of the disease with the word lupus erythematosus is not only vivid but also rich in connotation.

For details, please refer to the encyclopedia [Lupus erythematosus].

What is caused by the red class wolf cang:

1. Genetic factors: the prevalence of relatives of patients is significantly increased, among which the prevalence of identical twins is 24% to 65%, and the prevalence of dizygotic twins is only 2% 9%, indicating that the incidence of lupus erythematosus is related to genetics.

2. Ultraviolet rays: Ultraviolet rays can cause apoptosis of some cells and cause antigen exposure. Estrogen: Estrogen can make the condition worse after taking it, suggesting that estrogen has a relationship with the onset of lupus erythematosus.

3. Drug factors: such as isoniazia, minocycline, quinidine, etc., can be used as foreign antigens to activate the human immune system, and then produce antibodies to cause tissue damage.

4. Infectious factors: pathogenic microorganisms such as cytomegalovirus, hepatitis C virus, and Epstein-Barr virus are common foreign antigens, which can cause the body's immune system to produce autoantibodies.

Data Development:

Lupus erythematosus is a general term for a class of chronic, reversible autoimmune diseases, which are commonly found in women of childbearing age. The most characteristic symptom of lupus erythematosus is the appearance of butterfly erythema on the cheeks.

The name "lupus" is due to the fact that in the past, people thought that the facial erythema of the disease was caused by a wolf bite. In addition to the ** lesions, the lesions of lupus erythematosus can also affect multiple organs and systems.

Lupus erythematosus still lacks the best means, but through early diagnosis and standardized synthesis, the prognosis of this disease can be significantly improved, and the vast majority of patients can control their condition and be able to work, live, and give birth normally.

These include butterfly erythema, confluent macules with pruritic, papules, purpura or ecchymosis, bullae. Accompanied by organ injury, there can also be fever, fatigue, anorexia, mouth ulcers, arthralgia and other symptoms, as well as pulmonary interstitial fibrosis, pericardial effusion, pleural effusion, ascites, kidney disease and other complex symptoms.

There are erythema, plaques, or papules of varying sizes, covered in scale, and annular, multicircular, or arcuate erythema above the ** surface. In combination with Sjögren's syndrome, symptoms of dry mouth and eyes can also occur, and in combination with kidney damage, symptoms such as hematuria, oliguria, increased blood pressure, and edema may occur.

It is a genetic disease that causes large red sores on the chest.

It is not fully understood, but it is believed to be related to the following factors.

1.Genetic factors.

The onset of systemic lupus erythematosus tends to run in families, and the first or second degree relatives of SLE patients have LE or other autoimmune diseases; The rate of SLE in monozygotic twins can be as high as 70% (24% 69%), and in dizygotic twins it is 2% to 9%; At present, more than 50 gene loci related to SLE have been found, most of which are HLA and quasi-genes, such as DR2, DR3, DQA1, DQB1 and C4AQ in HLA genes in HLA D region.

2.Sex hormone.

The disease is more common in women of childbearing age, and pregnancy can induce or worsen SLE. However, the evidence is insufficient.

3.environmental factors and others.

Ultraviolet radiation can excite or aggravate LE, which may be associated with damage to keratinocytes, changes in DNA or release of "hidden antigens" or neoantigen expression that cause the body to produce corresponding antibodies, thereby forming immune complexes and causing damage. Drugs such as hydralazine, procaine, methyldopa, isoniazid, penicillin, etc., can induce drug-induced lupus erythematosus. Certain infections (eg, streptococcus, Epstein-Barr virus, etc.) can also induce or exacerbate the disease.

Lupus erythematosus is not a ** disease, but an autoimmune disease.

It is more common in young women.

The main features are: butterfly erythema or discoid patches, light sensitivity, as well as mouth ulcers, joint pain, etc.

The symptoms of the disease are highly varied, and early diagnosis, that is, before the absence of specific symptoms (eg, butterfly erythema), is difficult.

To be sure, there is no way to do anything with current medical technology (whether TCM or Western medicine).

For autoimmune diseases, the most effective drugs are of course hormonal drugs (such as prednisone) In recent years, the combination of traditional Chinese and Western medicine** has worked well.

The 10-year survival rate of subacute patients can reach more than 80%, and the prognosis is still relatively good.

Hello: There are several types of medications for systemic lupus erythematosus**

1) Non-steroidal anti-inflammatory drugs (NSAIDs) In the process of systemic lupus erythematosus, they are mostly used for mild patients with fever, joint pain, myalgia, fatigue and other symptoms, but no obvious visceral or blood system is affected. Proper use of such drugs can relieve symptoms and reduce the amount of adrenocorticosteroids and their use. Ibuprofen, Yimeili, Mobico, diclofenac sodium (including voltarin, Dafen, Intarin, Ausco, diclofenalgesia, etc.), Tupdone and so on can be used as options.

However, this class of drugs has adverse reactions such as digestive tract reactions, kidney damage, and elevated liver enzymes, and the course of treatment should not be too long. It should be used with caution in patients with systemic lupus erythematosus nephropathy to avoid aggravating kidney damage.

2) Antimalarial drugs The antimalarial drugs chloroquine and hydroxychloroquine have anti-inflammatory, immunosuppressive, anti-photoallergy and stable nucleoprotein effects. It is especially suitable for low-grade fever, arthritis and rash in patients with systemic lupus erythematosus, and has the effect of slowing down and stabilizing the progression of non-fatal lesions of lupus. If used in combination with prednisone (prednisone), the dose of prednisone can be reduced.

For those with predominant arthritis symptoms, it can be used in combination with non-steroidal anti-inflammatory drugs. The usual dose is chloroquine 0 25 g, taken once a day; Hydroxychloroquine 0 2-0 4 grams, divided into 1-2 times a day. Some patients can take it 5 days a week.

After the symptoms are controlled, the drug can be taken every other day or 2 days a week. Generally, the peak of efficacy is reached 1-2 months after taking the drug. Due to the slow excretion of antimalarial drugs, the tissue affinity is strong, especially in the eye, causing corneal deposition and retinopathy, which can be reversed if the drug is stopped in time.

In general, eye examinations should be done every 6 months after taking the drug.

Death. (4) Immunosuppressants for ** systemic lupus erythematosus are: cyclophosphamide, azathioprine, chlorambucil (also known as CBL348), methotrexate, vincristine and cyclosporine (cyclosporine human), etc.

It is commonly used in severe and refractory systemic lupus erythematosus, such as lupus nephritis and central lupus. Lupus arthritis requires little or no such drugs**, except in the rare number of people with destructive arthritis, methotrexate is an option.

In addition, there are still some immunology-related methods, such as plasma exchange and immunoadsorbent**, high-dose immunoglobulin intravenous impulse**, leukocyte exchange**, etc., which are still in the research stage.

Traditional Chinese medicine has been widely used in ** systemic lupus erythematosus, and most of them are treated according to syndrome differentiation. At present, the single flavor drug is mostly used with tripterygium wilfordii. Tripterygium wilfordii polyglycoside tablets 10 mg each time, 3 times a day, have a certain effect on joint pain, myositis and proteinuria of mild systemic lupus erythematosus, but it is easy to ** after stopping the drug.

As long as it's not congenital, it's saved.

At present, systemic lupus erythematosus is mainly based on hormones, immunosuppressants and other drugs, but these methods only relieve symptoms and are difficult to achieve.