Antistreptococcal hemolysin O assay 362 4

Rheumatic fever, typhoid fever, acute glomerulonephritis.

Categories: Healthcare.

Problem description: Since the tonsillectomy surgery, the tonsils have not felt uncomfortable, but the low-grade fever has been 37 for more than a month.

Antistreptolysin 'o' aso iu ml

I'm in a hurry, so I'm asking an expert doctor for valuable advice!

Elevated antistreptolysin O is common in rheumatic fever, hemolytic streptococcal infection, acute glomerulonephritis, and other diseases.

An elevated anti-"O" value suggests a haemolytic streptococcal infection. Therefore, diseases caused by infection with this bacterium (such as scarlet fever, erysipelas, acute nephritis, etc.) will increase the anti-"O" value. Since the changes in anti-"0" and erythrocyte sedimentation rate are non-specific, the diagnosis of active rheumatism should still be considered in conjunction with clinical manifestations even if the patient's anti-"0" and erythrocyte sedimentation rate are both increased.

In some disorders not clearly related to hemolytic streptococcus, the anti-"O" value may also be increased. For example, a small number of patients with hepatitis, nephrotic syndrome, tuberculosis, connective tissue diseases, subacute ** infected endocarditis and some patients with Henoch-Schonlein purpura should be comprehensively analyzed in combination with clinical data during differential diagnosis.

In patients with hypercholesterolemia, macroglobulinemia, and multiple myeloma, ASO may also be elevated.

The significance of C-reactive protein is mainly to indicate acute inflammation, and its elevation can be seen in:

1. Tissue damage, infection, tumor, myocardial infarction and a series of acute and chronic inflammatory diseases, such as rheumatoid arthritis, systemic vasculitis, polymyalgia rheumatism, etc.

2. Indicators of postoperative infection and complications: CRP of patients after surgery is increased, and the CRP level should decrease 7-10 days after surgery, if CRP does not decrease or rises again, it indicates that there may be infection or thromboembolism.

3 It can be used as a differential diagnosis of bacterial infection and viral infection: most bacterial infection will cause the patient's serum CRP to increase, while viral infection will not increase most of them.

4 In recent years, some studies have pointed out that the use of hypersensitive latex enhancement method to measure CRP can improve the sensitivity of the measurement, and can be used for coronary heart disease and myocardial infarction risk**.

In the case of acute rheumatic fever, penicillin ** should be used, generally procaine penicillin 40 800,000 units once a day, intramuscularly injected for 10 to 14 days; or oxacillin sodium (oxazole penicillin sodium) 1.2 million units intramuscularly once. However, if your test result is increased, it should not be acute rheumatic fever, and it is recommended to go to the hospital for further investigation** in order to treat the symptoms**.

Answer]: Antistreptolysin"o"It is one of the metabolites of group A streptococcus, which can lyse human red blood cells and has strong antigenicity. After the body is infected with group A streptococcus due to pharyngitis, tonsillitis, scarlet fever, erysipelas, pyoderma, rheumatic fever, etc., it can produce Streptococcus selltana hemolysin O antibody, namely"anti-streptolysino(aso)"。

Normal reference value] 200IU ml.

Clinical significance] ASO assay is valuable for the diagnosis of group A streptococcal infection, and its presence and content can reflect the severity of susceptible center infection. Rheumatic fever, acute glomerulonephritis, erythema nodosum, scarlet fever, acute tonsillitis and other ASOs are significantly elevated; A small number of patients with hepatitis, connective tissue disease, tuberculosis and multiple myeloma can also have an increase in ASO.

Take 1 drop of 1:15 dilution of patient serum and 1 drop of normal serum, drop them on both sides of the slide, and then add 1 drop of streptolysin "O" on each side, and gently shake for 1 minute to mix well. Add 1 drop of latex reagent to each of the above mixtures, gently shake for 3 minutes to mix well, put the reaction plate on the experimental table, and observe the results immediately

Those with clear agglutination are positive, and the serum titer is greater than 250u; Negative in the absence of agglutination. Note: If the serum titer needs to be further determined, the positive serum is diluted with normal saline, and then the above steps are repeated, if it is still clearly agglutinated, the serum titer is greater than 500u.