Is there a way to target osteoarthritis, cartilage wear and inflammation, stem cells

Osteoarthritis is a degenerative disease, due to age, obesity, strain trauma and many other factors caused by articular cartilage degeneration, articular margins, subchondral and bone reactive hyperplasia.

The main components of articular cartilage are cartilage collagen and proteoglycans, of which cartilage collagen is the material for repairing cartilage, and proteoglycan is a protective agent for lubricating cartilage.

Osteopeptide Oral Liquid contains sufficient cartilage collagen and proteoglycans, which can fully meet the daily nutritional needs of people with cartilage damage, promote bone repair, and help fight osteoarthritis.

Osteoarthritis is most common in the hands, lower back, neck, and weight-bearing joints such as the knees, hips, and feet. Osteoarthritis mainly occurs in the cartilage (i.e., the tissue that cushions the end of the bone within the joint), and studies have shown that the aging and loss of mesenchymal stem cells is one of the causes of osteoarthritis. Due to the damage to the cartilage, the ability of mesenchymal stem cells in the body to repair tissues and promote cartilage regeneration is weakened, coupled with the invasion of inflammation to accelerate the decomposition and wear of cartilage, resulting in irreversible pathology, in some cases, all cartilage may wear out, leaving bones that rub against each other, causing pain.

Therefore, repairing cartilage and inhibiting inflammation have become the key points of osteoarthritis!

Osteoarthritis, cartilage wear and inflammation.

In the early stage of osteoarthritis, it is generally conservative and relieves pain; In the later stages of development, severe cases are surgical replacement of joints. The joint is a relatively closed cavity structure, basically in the case of osteoarthritis, it is a symptom but not a cure, and the operation is also faced with problems such as allogeneic rejection and sequelae.

Mesenchymal stem cells are pluripotent stem cells in the mesoderm in the early stage of development, which have the functions of multi-directional differentiation, immune regulation and tissue repair. Transplantation of exogenous mesenchymal stem cells is a new pathway for osteoarthritis.

Transplantation of new mesenchymal stem cells can inhibit osteoarthritis, relieve pain and swelling, repair degenerated or damaged cartilage, and promote cartilage regeneration. It not only prevents the further deterioration of the condition, but also reverses the pathological process, fundamentally solves the lesions of osteoarthritis, and reduces. Therefore, stem cells are a new way to be superior to conservative and surgical.

Stem cells have great potential in medical treatment, and Duomu Health can connect ordinary patients with a good resource of Japanese stem cells.

Uncle Li, who is over sixty years old, used to be an excellent teacher, and this profession realized the value of life for him, but also made him fall ill, and he not only suffered from cervical spondylosis and frozen shoulder for a long time; When he retired, he thought that he could enjoy his old age easily and happily, but he never thought that he would suffer from knee osteoarthritis. After suffering from knee osteoarthritis, it made it difficult for him to walk, and he also had no chance to go for a morning run.

How to understand osteoarthritis concretely?

If osteoarthritis makes you feel very abstract, then let's take an example: when we eat pig's feet, we can also see that there is a layer of white cartilage on the surface of the pig's joint, and this cartilage is the cartilage on the surface of our knee joints. At this time, the cartilage acts like when screwing, in order to avoid direct contact between iron, a gasket is added in the middle to play the role of cushioning protection.

As shown in the figure below: the incidence of osteoarthritis is mostly in the elderly, and the prevalence rate in people over 65 years old can reach 60%-90%, which means that almost all people over 65 years old have osteoarthritis, but the severity is different. Because osteoarthritis is a joint degeneration caused by the wear and tear of cartilage on the joint surface, it is more likely to occur in joints with heavy weight and more activities, such as knees, spine (cervical and lumbar spine), hips, ankles, hands and other joints, with knee osteoarthritis being the most common.

How do I know if I have osteoarthritis? Very simple.

First of all, you have to be 65 years old and above (of course, it does not mean that there is no one who is less than 65 years old, but it is more common for people over 65 years old); secondly, repeated pain in the joints in the past month, sometimes good and sometimes bad; Again, when I get up in the morning, I feel that the joints have become stiff and inflexible, but the joints will be flexible after three or five minutes of movement, and the stiffness will never exceed 30 minutes. Finally, if you go to the hospital for a X-ray, you will find reports that your knee joint space is narrowed or osteophytes are formed. If you have several of the above symptoms, you may be an osteoarthritis patient.

At present, there is no better way for the medical community to stop the degeneration and wear of articular cartilage, and we can only protect our joints by changing our lifestyle habits and taking medicine to relieve symptoms.

Usually, we should try to reduce the pressure on the joint to protect the knee joint, such as controlling weight, avoiding mountaineering, climbing stairs, avoiding squatting, strenuous exercise, and appropriate swimming, cycling and other moderate weight-bearing exercises. In terms of drugs, Western medicine can take non-steroidal anti-inflammatory drugs and cartilage protection drugs, as well as intra-articular injection drugs to protect cartilage, but Western medicine cartilage protection drugs are controversial in the world, that is, the effect is not accurate, may or may not be effective.

Of course, when the above conservative ** does not relieve the pain or the joint movement is seriously affected, the surgery **is final**. Finally, for osteoarthritis, if you can conservatively not take medicine, you can take medicine without surgery, and you have to do surgery, then you can only restore joint function through surgery.

No, if it's damaged, it's damaged, and how can it be possible to generate a new one, so it definitely won't regenerate.

No, you can't. The cartilage worn out by arthritis is non-renewable, and can only be surgically used to cushion some artificial cartilage to maintain joint function.

The cartilage worn out by arthritis cannot be regenerated because the articular cartilage does not contain any blood vessels, so there are no regenerative cells.

Generally speaking, yes, but you must follow the doctor's instructions.

Mesenchymal stem cells, which have been widely considered to be seed cells with wide application prospects in the field of tissue engineering and regenerative medicine, are a kind of pluripotent adult stem cells. Studies have shown that mesenchymal stem cells can be induced to differentiate into osteoblasts, fat cells, muscle cells, nerve cells, epithelial cells, etc. in vitro. Many in vivo studies have shown that mesenchymal stem cells can migrate to the site of injury and participate in the repair of damaged tissue.

At this stage, some scholars have used chondrocytes and mesenchymal stem cells to co-culture, which is not only conducive to the microenvironment formed by mature chondrocytes, but also the cytokines secreted to induce the differentiation of mesenchymal stem cells into chondrocytes, and the cytokines secreted by mesenchymal stem cells at the same time promote cell proliferation and synthesis matrix, and prevent and treat chondrocyte dedifferentiation in vitro.

Stem cell intervention in arthritis resolution.

Scheme 1, directional intravenous reinfusion of stem cells.

Stem cell reinfusion** by extracting high quantity and quality of stem cells back into the patient. Harness the self-replication and differentiation potential of stem cells to repair damaged cells and restore the normal function of damaged organs and tissues.

The automatic homing effect of stem cells is used, that is, stem cells will automatically transfer to damaged lesions in the human body and differentiate to generate all kinds of cells required, so as to repair the inherent cells of the human body system, restore the function of the system, improve the patient's condition, and achieve the purpose of achieving the best results.

The second option is local targeted transplantation of stem cells.

Stem cell targeted transplantation is to transplant high quantity and quality stem cells directly into the patient's joint cavity, and use the self-replication and differentiation potential of stem cells to repair damaged cells and restore the normal function of damaged organs and tissues.

Stem cells will reach the lesion site to repair, replace damaged cells and tissues, and differentiate into immune cells to repair the immune system and restore the immune regulatory function to normal levels; On the other hand, stem cells secrete a variety of cytokines, which can inhibit inflammatory cell mediators and reduce bone and joints

Synovial destruction can effectively control the progression of the disease, so as to achieve the goal of effective ** disease.

With the maturity of stem cell technology in Japan, more and more clinical cases have also been passed by some osteoarthritis patients in ChinaMulti-harmony healthGo to Japan to receive stem cells**. Stem cells, a new method, will eventually become the third generation of diseases after drugs and surgery.

Stem cell arthritis is through the in vitro culture of umbilical cord mesenchymal stem cell cells with angiogenesis and active tissue repair, and the active cells are targeted and implanted on the joints by microinjection implantation technology.

Mesenchymal stem cells can be turned into fat cells, bone cells, muscle cells, nerve cells, liver cells, cardiomyocytes, endothelial cells, and so on, which allows mesenchymal stem cells to repair tissue and organ damage in various parts of the body.

Stem cell arthritis is currently the most consistent and effective and thorough method to improve the patient's environment, regulate immune function, and activate damaged and dormant cells. After the cells are activated, they can grow normally, multiply, repair damage in the body, prevent further destruction of joint structures, inhibit abnormal immune function, curb the development of complications, and restore the normal function of the body.

For knee femoral arthritis, mesenchymal stem cells** arthritis will not cause obvious ***, systemic intravenous infusion can effectively regulate the patient's immunity, mesenchymal stem cells can not only improve the clinical symptoms of arthritis, but also realize the repair and regeneration of articular cartilage. Now the best effect of stem cells is Japan, and here it is mentioned that there are many successful cases in stem cells.