The latest discovery that the coronavirus has an Achilles heel, what exactly is the Achilles heel

The latest discovery is that coronaviruses have an Achilles' heel, and the Achilles' heel of coronaviruses is that when they interfere with the process of "frameshifting" ribosomes by coronaviruses, they can inhibit the virus's ability to replicate.

1: New research discovers the Achilles' heel of coronavirusesA research team composed of a number of foreign universities has published a new ** article in the journal Science, which has discovered the "Achilles' heel" of coronaviruses, including the new coronavirus. This study successfully revealed the interaction between the viral genome and ribosomes in the process of "frameshift" for the first time, and found that the virus has "fine control" over the ribosome "frameshift" process, indicating that if it can interfere with the "frameshift" process of the coronavirus, it can effectively inhibit the replication ability of the virus, and then develop related drugs to fight the new coronavirus.

2. The pathogenic principle of the coronavirusIf you want to deal with the coronavirus, you need to have a clear understanding of the pathogenic principle of the coronavirus. Coronaviruses are unable to reproduce to produce offspring, and need to constantly replicate themselves by infecting normal cells, and then infect other cells, and so on, when the number of infected cells exceeds a certain number, the body will not be able to function properly.

After the coronavirus enters a normal cell, it uses the cell's own ribosomes to synthesize proteins needed by the virus. In normal cells that are not normally infected by the virus, ribosomes read their own RNA information and then synthesize normal proteins. When the coronavirus enters the cell, it interferes with the normal position of the cell to read the RNA, resulting in a "frameshift" when the cell reads, and finally synthesizes the protein required by the coronavirus.

Relevant research experts said that if the RNA sequence of the synthetic coronavirus protein can be captured, the RNA sequence can be targeted and inhibited through compounds, thereby preventing the coronavirus from replicating in the body.

Three: The preventive measures of the new coronavirus, including the new coronavirus, have not yet appeared in the world that can be effective, but it is believed that with the continuous progress and development of human medical technology, there will be drugs that can be effective in the future. Until then, the most important way we can control the pandemic is to prevent infection, and the most effective way to prevent infection is to get vaccinated.

When the human body is vaccinated against the new coronavirus, it will continuously produce antibodies against the virus in the body, and once the new coronavirus is found to enter the body, it can be detected and eliminated in time, which can reduce the situation of the new coronavirus infecting the body. When the vaccination rate of the whole population reaches 70-80%, a herd immunity barrier can be built, which can prevent the occurrence of mass infection, and then control the development of the new crown virus epidemic, which is the main reason why many countries and regions around the world are vigorously encouraging people to get vaccinated.

For the first time, this study has successfully revealed the interaction between the viral genome and ribosomes in the process of "frameshift", and found that viruses have "fine control" over the process of ribosomal "frameshift", which is expected to promote the development of drugs that inhibit viral replication by interfering with the "frameshift" process. The study also showed that a molecule called merafloxacin is a compound that better inhibits the "frameshift" process. It can reduce the titer of the new coronavirus by 3-4 orders of magnitude and is not toxic to cells.

Fluoroquinolones inhibit the "frameshift" efficiency of the coronavirus and other coronaviruses. This study shows that a molecule called merafloxacin is a compound that better inhibits the "frameshift" process. It can reduce the titer of the new coronavirus by 3-4 orders of magnitude and is not toxic to cells.

The transfer of ribosomes by the coronavirus is a very delicate control. If this control can be disrupted, the virus can naturally be suppressed.

The Achilles' heel is that it spreads very quickly, and the incubation period is very long, and there is a great possibility of mutation.

The lungs of people are the most vulnerable to attack.

The new coronavirus attacks the weakest part of the human body, and whichever part is problematic, it will enter first.

According to the latest news released by the people**, it can be learned that the research team composed of many universities has found the "Achilles heel" of the new coronavirus. ”The breaking of this news has made many people feel very happy, so this will also mean that mankind has hope to defeat the new coronavirus. Everyone knows what kind of virus the new coronavirus is, and it can be said that it is a very worrying and dangerous infectious virus.

So far, the new crown virus has not completely dissipated, and there are still hidden dangers around the world, which have to make people worry. <>

Novel coronavirusThe full name of the new coronavirus is the new coronavirus, which broke out at the end of 2019, and has not completely dissipated in 2021, and there is still a phenomenon of infection in various places. The new coronavirus is a large virus, and infected people will have difficulty breathing, fever, cough, etc. In severe cases, it can lead to pneumonia or kidney failure, which can lead to death.

Now that the new coronavirus has also been found to be a variant, it can be said that the "virulence" of this virus is becoming more and more serious. <>

The prevention and control of the new crown virus in all parts of the world, at present, the best prevention and control of the new crown virus is China, and the most serious region is India. In the rivers of India, it is even said that the corpses of people who have died of the new coronavirus can be seen all over the roadside. And most people in India are poor, so they can't afford to get the vaccine.

What's more, India's ** did not accept our China's bailout, and insisted on going its own way, which led to a phenomenon like today's. <>

Is humanity expected to defeat the coronavirus completely? As things stand, it's still a bit difficult, given that countries like India and the United States are completely out of control of the coronavirus. And the people of their country are not very aware of this, simply put, they are not afraid of death.

Even if we in China can completely defeat the new coronavirus, they are still living in the virus, so so far there is not much hope for mankind to completely defeat the new coronavirus.

Hopeful. Because today's human medical science and technology are very advanced, and human wisdom is infinite, it is definitely possible to defeat the virus.

Humanity is expected to defeat the new coronavirus completely, because medicine is still relatively advanced and people are united. Will definitely defeat the virus.

Of course, there is hope, and now that the Achilles' heel has been discovered, the virus can be defeated with a few actions that can be targeted.

Hopefully, a lot of drugs have been developed, and many people have received the vaccine, so the hope is very high.

I think it's unlikely, because the virus is mutating all the time, and a lot of vaccines are useless now.

I think there is hope because the current prevention and control measures are very strict, and everyone is very cooperative.

Weakness: How to defeat the new coronavirus, it's all nonsense.

1. Myth: Drinking banlan root and smoked vinegar can prevent the new coronavirus

2. Myth: Smoking can prevent viral infections

3. Rumor: Salt water gargle antivirus

4. Fireworks can curb the epidemic of respiratory diseases

5. Myth: Taking antibiotics can prevent new coronavirus infection

Scientific interpretation: antibiotics are used for bacterial infection, the causative agent of pneumonia is the coronavirus, taking antibiotics not only has no preventive and ** effect, but may cause adverse drug reactions and even destroy the normal intestinal flora.

6. Rumor: Eating "Tamiflu" and "Virion" can prevent the new coronavirus

7. The mysterious disease that broke out in Wuhan has been confirmed to be a new SARS virus

8. Rumors: The SARS virus has never disappeared and has always been parasitic in bats

9. Rumors: The correct way to wear a mask: when you have a cold, the color is facing outward, and it is the other way around if you don't have a cold

10. Rumor: Drinking lactoferrin can inhibit the new coronavirus

Comprehensive: Scientific rumor refutation platform, people**, fruit shell, more true.

Review expert: Tang Qin, researcher of the Department of Science and Technology Popularization of the Chinese Medical Association.

Liu Guanyang is the chief pharmacist of the Fourth Medical Center of the PLA General Hospital.

Zhang Hua is the chief physician of the respiratory department of Hepingli Hospital.

Xu Weisheng is an associate researcher at the Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention.

Chen Rui is an associate professor at the Institute of Communication Psychology, School of Journalism, Communication University of China.

The discovery of the fatal weakness of the new coronavirus can be said to be a gratifying thing, and the virus can only replicate after infecting the cell and the host, and can continue to survive. Because of such characteristics, scientists have conducted further research. They found that there is a 'frameshift' relationship between viruses and accounting, and that viruses have "fine-grained control" over the ribosomal "frameshift" process.

We all know that normal ribosomes follow RNA movement, and when three RNA letters (i.e., three genetic codes) are read at a time, when only two of them are moved, the ribosome misalignment is called 'frameshift'. If it occurs in healthy cells, it will lead to dysfunction of cellular proteins, and the new coronavirus relies on 'frameshifts' to regulate the function of viral proteins.

With this new discovery, as long as we interfere with the 'frameshift' of the virus, so that the virus does not have a way to reduce the number of viruses, it should not be difficult to eliminate the active virus and really kill the virus without affecting the health of the body. It can be said that this finding is very important and gratifying for the global epidemic.

Recently, there have been several local cases of new coronavirus infection in Liaoning, and because they are all asymptomatic people, there are certain difficulties in screening. Due to the emergence of such local asymptomatic infections in China, everyone's nerves became tense again, and they began to sign up for vaccination, from the very beginning of indifference and fear of sequelae of vaccination. Up to now, everyone has started to make appointments and queue up for vaccination, and everyone's attitude has changed a lot.

I still remember that at the beginning, everyone was afraid of vaccination, and in order to encourage vaccination, various places used various daily necessities to mobilize everyone's enthusiasm. Nowadays, most people are aware of the dangers and potential risks of infection, and it is more practical to protect themselves from infection than to get vaccinated.

Through complex biochemical experiments, the researchers managed to capture ribosomes at the "frameshift" site of the coronavirus RNA genome. Then, cryo-EM studies showed that the viral RNA formed a pseudoknot structure and stayed at the entrance of the ribosomal mRNA channel, creating tension in the mRNA and promoting the occurrence of "frameshift", while the nascent viral polyprotein formed a significant interaction with the ribosomal channel. That is, the interaction between the false knot and the ribosome causes the occurrence of "frameshift".

The discovery that viruses have "fine control" over the ribosomal "frameshift" process is expected to facilitate the development of drugs that inhibit viral replication by interfering with the "frameshift" process.

It is a weakness formed by this cell, and if this place is breached, in fact, this bacteria and viruses will not exist.

It's that we're particularly afraid of heat, and this virus is particularly afraid of high calories, and it's also very afraid of alcohol, so this can also make it easier for us to eliminate the virus.

According to the latest article published by the journal "Science" on the 13th, a research team composed of the University of Technology Zurich in Switzerland, the University of Bern, the University of Lausanne and the University of Cork in Ireland has found the "Achilles heel" of coronaviruses, including the new coronavirus. For the first time, this study has successfully revealed the interaction between the viral genome and ribosomes in the process of "frameshift", and found that viruses have "fine control" over the process of ribosomal "frameshift", which is expected to promote the development of drugs that inhibit viral replication by interfering with the "frameshift" process.

New research found that the Achilles heel of the coronavirus also makes everyone feel very happy, we all know that viruses like the coronavirus have also had a very big impact on our lives, fortunately as Chinese we have not suffered a great loss, but in foreign countries it has spread, this study also found its Achilles heel,For the first time, the study has successfully revealed the interaction between the viral genome and ribosomes in the frameshift process, and if there is fine control over the ribosome frameshift process, it is possible to develop drugs that can inhibit viral replication by interfering with the frameshift process

This shows that this is a great step forward in the history of science, and we hope that it will be developed as soon as possible. At the same time, for the coronavirus, we should still learn to protect ourselves, and we must also actively protect ourselves in our daily life to avoid transmission.

Judging from the cases admitted, many patients have recovered very well after the new crown epidemic, but there are also a few patients whose condition is particularly serious, especially for the elderly, their own resistance is not very good, so it will have more serious consequences, so we must also learn to wash our hands frequently, pay attention to hygiene, actively carry out physical exercise, and control our weight to better improve our immunity.

In daily life, we should also try to quit smoking and limit alcohol, ensure that we have enough sleep time, pay attention to rest, and avoid staying up late to better build our body barrier. If you accidentally get the new crown epidemic, then we must also go to a regular hospital in time to carry out **, and at the same time, it should be noted that the isolation is lifted, and the body temperature needs to return to normal for more than three days, and the respiratory symptoms are significantly improved, so that everyone can understand this, and in daily life, we should also drink more water and rest more.