What causes ichthyosis?

Ichthyosis is a common multiple disease in life, so there are many reasons for ichthyosis, ichthyosis patients have no age, gender, region, ichthyosis patients are a relatively wide group, ichthyosis brings patients pain is also very large, to the patient's life, study, work and other aspects of the negative impact. The "ichthyosis" can be summarized into several major factors: genetic, psychological, chemical, endocrine, infectious factors or external factors, etc., which shows that the cause of the disease is multifaceted.

Clause. 2. The ** ichthyosis vulgaris gene that causes ichthyosis is located in 1q21, but the pathogenic gene has not yet been cloned.

Clause. 3. The pathogenic gene of lamellar ichthyosis is related to the mutation of glutamyl transferase 1 (TGM1) gene, which is the leading cause of ichthyosis.

Clause. 4. The pathogenic gene of sex-linked recessive ichthyosis encodes steroid sulfatase (STS), and the deletion or mutation of this gene causes microsomal steroids, cholesterol sulfate, and steroid sulfate synthesis disorders.

Clause. 5. The pathogenic gene of congenital bullous ichthyosis-like erythroderma is related to mutations in keratin 1 (krt1) and keratin 10 (krt10) genes, resulting in defects in keratin synthesis or degradation, affecting the normal arrangement and function of tensile microfilaments in basal keratinocytes, and then causing abnormal keratosis and epidermal release, which is also the leading cause of ichthyosis.

Hello, ichthyosis can be summarized into several factors: genetic, psychological, chemical, endocrine, infectious factors or external factors, etc., it can be seen that the hair of this disease is multifaceted, but not what factors and any part are related to microcirculation disorders.

The child has something like snakeskin on his body, especially on his arms, and now it has also appeared on his legs, the color is a little grayish, and the surface is rough to the touch, and it is ichthyosis on examination.

At present, ichthyosis is considered to be related to neuropsychiatric factors, endocrine disorders, immunological abnormalities, digestive tract diseases, etc.

Causes of ichthyosis:

Clause. 1. Genetics.

Scientific investigation has shown that the occurrence of ichthyosis, a common disease, is largely due to genetic reasons. Because of many genetic factors, the internal heat and blood toxicity of the body have become obstacles to the metabolism of some substances, and importantly, these residues are not easy to excrete from the body.

Generally speaking, these residues are greatly affected by temperature and humidity, and in summer, when the temperature is high and the air is humid, people often sweat and bathe, and the shadow of this residue is less disturbed. But once the time enters autumn or even winter, the temperature begins to decrease, the air is dry, dry, and contains very little water, which can easily make the adsorption left in the body on the body, clog the pores, and lead to the increase of stratum corneum and debris, and it is easy to cause ichthyosis for a long time.

In addition, it is recommended to try Zhang Jian** Studies have found that chromosomal genes are also the main cause of ichthyosis, chromosomes are the basic units of heredity, and any pair of chromosomes with defects may lead to hereditary diseases.

Clause. 2. Chemical infection.

With the development of social economy and the continuous improvement of industrial scale, industrial pollution has become more and more a topic that people cannot avoid. In particular, the chemicals and heavy metal poisons contained in industrial sewage are difficult to excrete from the body after being inhaled, which will form a huge hidden danger in the body and induce the occurrence of diseases such as ichthyosis.

Clause. 3. Abnormal keratin shedding.

Studies have shown that the lack of steroid sulfatase in the stratum corneum is an important cause of ichthyosis.

The occurrence of ichthyosis is due to genetic reasons leading to a certain substance metabolism disorder in the body, this metabolic residue is not easy to excrete from the kidneys, but has a strong affinity with **, when it accumulates in the body to a certain extent, it is gradually secreted into the body through the sebaceous glands and sweat glands, so as to achieve the purpose of excretion and clearance. However, as soon as the autumn begins, the temperature decreases and the climate is dry, the substance quickly solidifies as soon as it is secreted to the surface, and the moisture of the skin decreases, and the substance cannot be effectively dissolved, so it condenses and deposits in the stratum corneum.

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Ichthyosis is a common hereditary **keratosis disease, which occurs more than in children, mainly manifested as dryness and roughness on the extensor sides of the limbs or trunk, accompanied by diamond-shaped or polygonal scales, such as fish scales or snakeskin-like, and severe **chapped, stiff epidermis, resulting in sparse hair and abnormal perspiration, resulting in imbalance of water metabolism in the body and affecting the endocrine system.

Here are a few points about the causes of ichthyosis:

1. Hereditary: heredity is the main cause of ichthyosis, and its root cause lies in the genetic abnormalities in the chromosomes, so ichthyosis patients are more common in children and adolescents, but the disease is not contagious.

2. Seasonality: ichthyosis has a certain seasonality, and the patient's condition is usually more serious in cold and dry weather, and there will be a significant improvement in summer.

3. Discomfort: The cause of ichthyosis is the blockage of hair follicles and sweat glands, which leads to the secretion of sebaceous glands and sweat glands, and eventually loses moisture and becomes abnormally dry, thus forming ichthyosis.

More than 80% of ichthyosis is genetic, and there is a low chance that the fetus is mutated due to the mother's high fever during pregnancy or oral medication and its factors. Another factor is due to premature birth, premature rupture of the amniotic fluid, severe asphyxia of the fetus, which is generally difficult for the fetus to survive. Preterm birth is very rare and causes ichthyosis, but it is very serious, usually lamellar ichthyosis or bullous ichthyosis.

A common hereditary ** keratosis disorder, rooted in the genetic abnormalities in the chromosomes, is a hereditary disease, so it can be inherited, but not contagious, when the climate is dry in winter, pay attention to keep moisturized, pay attention to eating more vegetables and fruits in the diet, and eat some animal liver, carrots and other vitamin-rich foods appropriately.

You can use Mu's fish scales to clean, I used to be a fish, and then I used this to be good.

Compared with LI patients, only a very small number of CIE patients have recessive mutations in the TGM1 gene, resulting in transglutaminase-1 defects that cause structural abnormalities in the outer cell membrane, resulting in the disruption of barrier function[3][7]. However, evidence suggests abnormal intracellular aggregation and abnormal enzyme activity in some other patients, suggesting that the onset may also be due to secondary dysfunction of the epidermal transglutaminase system. Recently, 10 percent of 12 percent of CIE patients without TGM1 mutations had blunt mutations in the last two adjacent lipoxygenase (LOX) genes, ALOX12B and ALOX3 [8], with 60 percent of ALOX12B mutations and the remainder ALOXE3 mutations.

Most patients are born with collodion-like manifestations and soon present with mild to moderate CIE symptoms. A small number of patients have mild LI or self-healing collodion-like manifestations. The genes ALOX12B and ALOXE3 encode the enzymes 12R-LOX and ELOX, respectively, which are mainly involved in the metabolism of epoxyethanol in the epidermis and play an important role in the formation of the epidermal lipid barrier.

12R-LOX produces hydrogen peroxide of fatty acids, and ELOX acts as a hydrogen peroxide isomerase to synthesize epoxyethanol. There is also a recently confirmed CIE gene, called the squamoprotein gene, located on the chromosome. Squamoprotein is a transmembrane protein, and it is only known that it functions similarly to the carrier and the G protein-coupled receptor, and it is speculated that it may be a ligand formed by the membrane receptor to bind to the peroxidase pathway.

Ichthyosis is a common hereditary disease. It is mainly characterized by dry, rough limbs on the extensor sides or trunk**, accompanied by diamond-shaped or polygonal scales, and the appearance is fish-like or snakeskin-like. Aggravated in the cold and dry season, relieved in the warm and humid season, easy to **.