What do mitiglinide calcium tablets come from? What does it do

Of course, calcium tablets are calcium supplements, and any osteoporosis is quite effective, but I personally think it is better to eat more shrimp or something.

I don't really understand, I don't remember if it's high blood sugar or low blood sugar.

Mitiglinide calcium tablets are indicated for improving postprandial hyperglycemia in patients with type 2 diabetes mellitus (only for patients who cannot effectively control blood sugar after diet and exercise** or patients who cannot effectively control blood sugar after adding -glucosidase inhibitors on the basis of diet and exercise**).

Pharmacological effectsMitiglinide binds to sulfonylurea receptors on pancreatic islet cell membranes, inhibits ATP-sensitive K+ channels on pancreatic islet cell membranes, resulting in cell depolarization and increased intracellular Ca2+ concentration, thereby promoting insulin secretion and lowering blood glucose. Toxicity study genotoxicity: In bacterial revert mutation experiments, mitiglinide did not induce mutations in genes.

In mouse lymphoma assays, mitiglinide calcium induces gene mutations only at concentrations above 1047 g ml under metabolically activated conditions. In the chromosomal aberration assay of mammalian cells, the concentration of mitiglinide calcium hydrate reached 1000 g ml without inducing chromosomal abnormalities, and chromosomal abnormalities were induced at 1300 g ml concentration. In the out-of-program DNA synthesis assay using rat hepatocytes, mitiglinide did not induce out-of-program DNA synthesis.

In the mouse micronucleus test, mitiglinide did not induce chromosomal abnormalities or inhibit spindle formation. Reproductive toxicity: In the fertility and early embryonic development toxicity test of rat oral administration, the non-toxic dose of mitiglinide calcium hydrate was 500 mg kg day for male parents, 150 mg kg day for female parents, 500 mg kg day for reproductive function, and 1500 mg kg day for embryos.

In the developmental toxicity test of rat embryos and one-litter, the daily dose of 1000 mg kg of mitiglinide calcium hydrate caused fetal weight loss and delayed bone annihilation due to hypoglycemia in maternal animals from the induction stage, and the survival rate was reduced within 4 days after birth. The non-toxic dose of Migli Zinai calcium hydrate to maternal animals and fetuses is 300 mg kg day. In the rabbit embryo-fetal developmental toxicity test, the daily dose of 80 mg kg of mitiglinide calcium hydrate increased the mortality rate after embryo implantation, and a small number of maternal animals suffered abortion. The non-toxic dose of miciglinide calcium hydrate to maternal animals and fetuses is 20 mg kg day. In rat and rabbit tests, no teratogenic effects were found at all doses.

Carcinogenicity: In carcinogenic trials in mice and rats for 104 weeks, mitiglinide showed no carcinogenic effects.

In 1991, the Japanese company applied for patents for the drug compound of mitiglinide and its use in the United States, Japan, Europe and other countries, and disclosed the method of synthesizing the compound and its prescription as a general preparation of the drug. Since China's Patent Law did not grant patent protection to pharmaceutical compounds before 1993, the patent was not applied for in China.

In June 2002, Tangerine disclosed a patent for an immediate-release formulation containing calcium mitiglitinide in China. In August 2000 and November 2001, the French company Servier disclosed the patent for the synthesis method of preparing calcium mitiglitinide and its synthesis intermediate (dihydroindole). Apart from the above-mentioned patents, no other patents related to this compound have been published.

Therefore, the development, production and sale of mitiglinide calcium raw materials and their ordinary preparations (such as tablets, capsules, etc.) in China, and the use of this compound in patients with type 2 diabetes will not constitute infringement of the patents of others, but the compound cannot be synthesized using the method disclosed by Servier.