What is the heritability of essential tremor

Great advice promptly**.

The only symptom of essential tremor is tremor, which has occasionally been reported to be accompanied by anomalies in intonation and gait. Patients usually begin with the upper extremities, which mainly affect the upper extremities but can also affect the head, legs, trunk, and facial muscles, and manifests as postural tremor, with motor, intentional, or resting tremor components, which may be worse with directed movements. Essential tremor, also known as familial tremor, about 60% of patients have a family history, no cross-generational phenomenon has been found in multiple essential tremor families, the gender distribution is balanced, it is generally considered to be autosomal dominant inheritance, complete penetrance before the age of 65 to 70, there are also reported cases of incomplete penetrance and sporadic cases, the clinical characteristics of sporadic and hereditary people are completely consistent, and it is usually considered to be the same disease, but the related genetic abnormalities have not yet been identified.

The bimodal feature of the age of onset of essential tremor suggests that there may be two different abnormal genes, and that familial tremor occurs earlier than sporadic cases, suggesting that early-onset essential tremor is more strongly influenced by genetic predisposition, which significantly influences clinical subtype characteristics.

Analysis: Essential tremor is a dystonia disease, which is mainly manifested as tremor symptoms during special movements or postures.

Guidance: In patients with essential tremor, approximately 1 in 3 patients have a positive family history and are "autosomal dominant". Therefore, if there is a genetic background, the child is more likely to inherit it.

If the disease is not caused by genetic factors, it is less likely to be inherited.

1. Essential tremor is not common in our lives, so don't worry, it is a movement disorder, it is a disease caused by nervous system disorders, many people are worried that he has a genetic phenomenon, in fact, there is no need to worry, its genetic probability is very small, 2, at present, the specific ** for essential tremor is not very clear, it is generally believed that it is related to many factors, mainly the result of the joint action of peripheral muscle spindle afferent and central autonomic oscillators, And the type and age of onset are all different.

3. There are many means for essential tremor, and some patients with mild symptoms are not needed, and the commonly used means are drugs, such as adreno-receptor blockers, ethanol, etc., which are some commonly used drugs with good effects.

Patients: Essential tremor is a dystonic disorder characterized by tremor symptoms in specific movements or positions. Guidelines: Approximately 1 to 3 patients with essential tremor have a positive family history and are "euchromatic."

Essential tremor is also known as familial tremor, about 60% of patients have a family history, so essential tremor has a strong hereditary nature, essential tremor is more balanced in the gender distribution of family patients, there is no obvious difference in the proportion of men and women, the symptoms of this disease are usually fully manifested after the age of 65 or 70, and essential tremor should be timely, otherwise it will seriously affect the work and life of the patient.

Essential tremor is a disease that can be inherited, so it is also called familial tremor, its genetic probability is as high as 60%, usually autosomal dominant genetic characteristics, and some experts believe that the heritability of essential tremor is only 40%, the reason for such a huge difference is that the diagnostic criteria for essential tremor are inconsistent, and the correct evaluation of the family history of essential tremor depends on the correct understanding of the symptoms and clinical examination, so in order to confirm the diagnosis of this disease, a detailed examination must be done to judge.

The only symptom of essential tremor is tremor, the patient is usually accompanied by abnormal tone and slight gait, the patient usually starts from the upper limbs, mainly affects the upper limbs, affects the head and legs, trunk and facial muscles, the main manifestation is postural tremor, and there are also movement, imagery or resting tremor components, usually in the first few months feel the body vibration, and then when excited or excessive fatigue will also appear short-term activity normal.

Essential tremor is also known as familial or benign essential tremor, and postural or action tremor is the only manifestation. Essential tremor is an autosomal dominant disorder, the most common extrapyramidal disorder, and the most common tremor condition, with about 60% of patients having a family history. Essential tremor is a single symptomatic disorder, and postural tremor is the only clinical manifestation of the disease.

Postural tremor refers to a tremor caused by a limb maintaining a certain posture, which disappears naturally when the limb is completely relaxed. Tremor is common in the hands, followed by head tremor, and tremor of the lower extremities is rare in patients. Essential tremor is also characteristic of essential tremor that worsens with concentration, nervousness, fatigue, and hunger, and in most cases disappears temporarily after alcohol consumption and worsens the next day.

Coping symptoms**.

The disease is more common in the late teens or early adulthood, and tremor is the only clinical symptom, manifesting as postural or action tremor, often involving one or both hands or head, and symptoms do not become apparent until later. In addition to causing physical and social embarrassment, it usually does not cause disability, and in some cases tremor can interfere with the completion of fine motor movements such as writing, and when the laryngeal muscles are affected, it can affect speech, and the lower extremities are often not affected. Patients often report significant relief from small amounts of alcohol consumption, but this is short-lived and the mechanism is unclear.

Examination usually shows no other neurologic signs.

1 3 patients have a family history with autosomal dominant inheritance, and 2 pathogenic loci have been identified, localized at 3Q13 (FET1) and 2P22 25 (ETM or ET2).

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Wishing you good health!

There is a genetic component to essential tremor.

This one is hereditary.