What polymyositis and rheumatoid have in common

Polymyositis is a group of diffuse muscle inflammatory diseases characterized by symmetrical muscle weakness of the proximal limbs, neck muscles, pharyngeal muscles, muscle tenderness, and increased serum enzymes. Most scholars believe that the disease is related to an autoimmune disorder. Some scholars believe that it is related to viral infection or genetic factors.

Most of them have a subacute onset, and can occur at any age, more common in middle-aged people and above, and slightly more in women. Some patients have malignant tumors before the disease, and about 20% of patients have other diseases such as lupus erythematosus, scleroderma, rheumatoid arthritis, and Sjögren's syndrome. Due to the different scope of involvement, the clinical manifestations of the disease are diverse.

The disease usually peaks within a few weeks to months, with generalized muscle weakness and, in severe cases, respiratory muscle weakness, which is life-threatening. Therefore, early diagnosis and ** are very important. As long as corticosteroids or immunosuppressants** are used promptly, the prognosis of polymyositis alone is expected to be good, and the prognosis of patients with malignant tumors and various connective tissue diseases is poor.

Rheumatoid is a systemic autoimmune disease that is caused by a disorder of immune function in the body. Rheumatoid is mainly related to the joints, and in addition to the joints, the whole body such as the lungs, cardiovascular, **, and eyes will be affected, so it is actually a systemic disease. Rheumatoid is an autoimmune disease that belongs to the category of rheumatism, and there are currently about 5 million rheumatoid patients in China.

The clinical manifestations of rheumatoid are mainly symmetrical facet joint pain and morning stiffness, so many patients will find their hands stiff in the morning, and the morning stiffness time can be very long, more than half an hour, or even more than 1 hour, so rheumatoid is also the most classic disease among our most common rheumatism.

Both of them belong to rheumatology and immunology diseases, and when they exist at the same time, they are called overlap syndromes, and there is no professional systemic ** rheumatology and immunology diseases in the early stage. Polymyositis can be manifested as symptoms of rheumatoid arthritis, and many patients may be misdiagnosed in the early stage, thus delaying the disease.

Polymyositis is mainly manifested by muscle weakness and pain in the proximal limbs, which is characterized by "trilemma", difficulty in going up and down stairs, difficulty in lifting the upper limbs, and difficulty in squatting and standing up. Cardiac enzyme monitoring showed a marked increase in creatine kinase and myogenic changes on electromyography.

Rheumatoid arthritis is mainly swollen and painful joints.

Psychiatric disorders associated with polymyositis and dermatomyositis are connective tissue disorders of unknown cause. At present, it is considered to be an autoimmune disease, and in recent years, it has been believed that cellular immunity deficiency has important pathogenic significance, some people believe that the disease is closely related to malignant tumors, and it has also been reported that 50% of dermatomyositis patients over 40 years old have cancer. Vascular injury may be causative.

It can be induced by infection, sun exposure, drugs, and other factors. Polymyositis is the main factor in the onset of mental disorders, which lead to brain dysfunction secondary to physical diseases. However, only a small number of patients with polymyositis develop mental disorders, so polymyositis is not the only one associated with mental disorders**, and there are other factors related to the occurrence of mental disorders, such as other biological factors, including the patient's gender, age, genetic factors, personality characteristics, and previous history of neuropsychiatric disorders. Psychological factors include stress state, long-term psychological conflict, etc.; Environmental factors such as crowded living, noisy, humid environment, air pollution, etc.

All of the above factors can be precipitating factors for polymyositis and psychiatric disorders.

Symptom differences: polymyositis will cause proximal muscle weakness and myalgia; In addition to the above-mentioned muscle symptoms, dermatomyositis can also present with specific rashes, such as sunny rashes and shawl rashes;

Pathological differences: dermatomyositis is mainly vasculitis, and polymyositis is mainly hormonal inflammation.

The typical clinical manifestations of polymyositis are symmetrical proximal muscle weakness and muscle tenderness, while dermatomyositis has a variety of rashes in addition to the above clinical manifestations.

The best way is to take Chinese medicine, the effect is good, see how the joints are, I don't see the patient, I don't know what the extent, you can use Chinese medicine to dispel wind and cold, but the dosage must be large, but it doesn't work.

Let's distinguish the symptoms of rheumatoid arthritis from rheumatoid arthritis.

1) Laboratory and X-ray examination: rheumatic ASO positive (above 1:600), if negative, there should be nodular or annular erythema, how fast the erythrocyte sedimentation rate is, and rheumatoid factor negative.

Rheumatoid factor positive, if relatively stable in the middle and late stages, patients with negative rheumatoid factor should be examined on x-rays, with typical rheumatoid joint x-rays.

2) Affected joints: Rheumatism is dominated by the major joints of the four limbs (knees, hips, ankles, elbows, shoulders, and wrists). Rheumatoid disease is dominated by the facet joints of the four limbs (fingers, metacarpophalanges, and toes).

3) Clinical manifestations: acute onset, high fever, joint redness, swelling, heat and pain in the acute stage of rheumatism, and pain in the chronic phase of joint wandering or low-grade fever. Rheumatoid hand and foot small joints are swollen, painful, and stiff in the morning, which can invade large joints, often symmetrical, and deform both large and small joints.

4) Other comorbidities and prognosis: rheumatic limbs** with nodular or annular erythema, as well as cardiac lesions, and no deformity of the joints of the limbs. Rheumatoid systemic diseases, most of them have anemia, insomnia, poor appetite, joints can be stiff and deformed, and even lose the ability to work, and can not take care of themselves.

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Muscle weakness is accompanied by muscle pain, which can be a soft tissue injury caused by strenuous exercise or overexertion, or myositis due to certain drugs or other reasons.

Therefore, in this case, it is necessary to test the enzyme spectrum to see if there is an increase in the enzyme spectrum, and then combined with the patient's medical history, whether there is any recent strenuous exercise and other problems. If it is caused by overexertion and fatigue, it is necessary to rest more, and the symptoms will generally be relieved by rest.

Pain that is evident can be relieved by mouth with a nonsteroidal anti-inflammatory drug on a temporary basis. If myositis is a problem, it is necessary to use drugs that nourish the skeletal muscles and remove **, such as drugs that cause damage to the skeletal muscles.

Polymyositis refers to a rheumatological disease characterized by muscle weakness and myalgia. It often involves the proximal extremities, with symmetrical muscle manifestations, and some patients have cervical onset that can cause swallowing weakness and respiratory muscle weakness. Attention should be paid to the early stage of the disease, because long-term illness can affect the respiratory muscles and cause life-threatening.

Patients with polymyositis can be examined for muscle enzymes, which can be significantly elevated, and antibodies are positive in immunity. Patients with this disease should pay attention to whether there is a combination of tumors, and some cancer patients can also cause immune abnormalities and trigger inflammatory reactions.

In patients with dermatomyositis, the lesions are pleomorphic, and positive purplish-erythema is a specific sign of dermatomyositis. Manifestations are characterized by puffy purpish erythema on the upper eyelids of both eyes**. In addition, patients with dermatomyositis may have hirsutism, calcinosis, sclerosis, wheals, and erythema multiforme.

Calcinosis is more common in pediatric dermatomyositis, and sclerosis is more common after muscle atrophy in advanced dermatomyositis.

Although any striated muscle can cause dermatomyositis, the proximal muscles of the extremities are predisposed to develop and have a symmetrical onset. It is manifested as difficulty in elevating the upper limbs and squatting the lower limbs, unable to stand up after squatting, unable to move the whole body, unable to lift the head, and can involve respiratory muscles and heart muscles and be life-threatening. This is also a harmful manifestation of the more serious dermatomyositis.

Dermatomyositis is a disease that hurts the patient, so when it is found, it is necessary to carry out it in a timely manner, and at the same time, it is also hoped that the dermatomyositis patient can know why he has this disease, and try to stay away from dermatomyositis during the period.