Do you want to know how multiple Takayasu s arteritis can be better controlled?

Your question seems to be to tell the patient about the unique and effective approach to multiple Takayasu's arteritis.

But after reading the description of the following sentence, I feel that you are looking for an effective cure for this disease.

Takayasu's arteritis multiplex is a rheumatic disease that is known as an immortal cancer along with rheumatoid arthritis and SLE, and is very difficult. Therefore, it can only be understood according to the method you are looking for.

The file is in my electric mule.

It is about a 12-year-old girl in Henan. Blindness, pulselessness, diagnosis of multiple Takayasu'eritis.

She went to the First Affiliated Hospital of Zhengzhou Medical University in Henan Province for treatment, and the experts who received her were:

Professor Zheng Guangying, Chief Physician, Department of Ophthalmology; Professor Peng, Department of Pediatrics; Wang Huaili, Deputy Director of Pediatrics; Sheng Guangyao, director of pediatrics, etc.

Because it is in a stable period, glucocorticoids (prednisone), anticoagulation (aspirin), traditional Chinese medicine (thrombotong), etc. are used**.

You can use an electric mule to get there.

Categories: Healthcare.

Problem description: The patient's legs (back of the thighs, both sides to the calves) feel **surface or blood vessel pain and discomfort. Symptoms are weather-related: burning sensation when it's hot, chilling sensation at dawn, scratching, pinprick sensation. However, there is no abnormality in the overall observation of the appearance, and the touch

The temperature is normal, with local small areas of bruising. The hot day is the superficial blood vessels floating up the chain potato starting purple. In March of onset, there was no effect on walking and movement.

Analysis: Introduction to the disease.

Takayasu's arteritis multiplex is a chronic, nonspecific occlusive inflammation involving the aorta and its major branches. It is also known as aortitis syndrome, aortic arch syndrome, pulselessness, Takayasu disease, etc.

Prednisone 20 to 30 mg daily or dexamethasone 3 to 4 times a day. Systemic symptoms are relieved, and the dose of ESR is gradually reduced to discontinuation after normal erythrocyte sedimentation rate. The immunosuppressant cyclophosphamide may be added when systemic symptoms persist or when the disease has progressed markedly, which can help improve symptoms and reduce the dose of glucocorticoids.

The dosage of cyclophosphamide is generally 2 mg, and the peripheral blood cells should not be less than 3000 ul. 2. In the vascular occlusion phase, vasodilators such as torasulin 25-50mg can be used 3 times a day; Anticoagulants or platelet aggregation inhibitions, such as aspirin, are uncertain. If you have high blood pressure, you should be aggressive**.

If the stenosis is severe, surgery or percutaneous transluminal angioplasty** may be used.

Clinical manifestations 1. Active phase Most of the onset is slow, with systemic symptoms such as fever, general malaise, loss of appetite, weight loss, night sweats, arthralgia and fatigue. Localized pain and tenderness may occur outside the diseased arteries. Symptoms may resolve spontaneously during the active phase.

2. Vascular occlusion stage (1) Brachiocephalic artery type is manifested as dizziness, headache, vertigo, visual impairment, etc., and in severe cases, syncope may occur. The carotid pulse is diminished or absent, and a bruit may be heard, and in rare cases it is accompanied by a tremor. Fundus retinal anemia.

When the subclavian artery is affected, weakness, numbness, and cold sensation may occur in the affected limb, and intermittent limb pain may occur after activity. Decreased or absent radial pulse on the affected side, low or undetectable blood pressure, and pulselessness. (2) Main-renal artery type Due to lower limb ischemia, symptoms such as fatigue, numbness, cold sensation and intermittent claudication may occur.

The pulse of the lower limbs is weakened or disappears, the blood pressure is lowered, the hypertension can be increased, and some patients may also have intestinal ischemic colic and intestinal dysfunction. In patients with renal artery stenosis, hypertension is the main manifestation. On examination of the abdomen and kidneys, a bruit may be heard.

3) Extensive (mixed) type has the characteristics of the above two types, among which renal artery involvement is more common, so there is often obvious hypertension.

Takayasu'arteritis polysa is a group of chronic diseases with large blood vessels affecting the whole body as the main lesion. In terms of the patient, the main method is the use of internal medicine, and it can also be combined with the surgical method.

There are several kinds of drugs commonly used in internal medicine:

First, glucocorticoids, patients in the acute phase can choose sufficient amounts of hormones to take orally, and hormones can relieve the patient's symptoms and control the condition.

Second, immunosuppressants, methotrexate, cyclophosphamide, azathioprine, etc., can be selected, which is suitable for patients with poor efficacy of glucocorticoids, recurrent activity of the disease, and reduced hormone dose. It can also be combined with glucocorticoids at an early stage to improve the efficacy and reduce the dose and adverse reactions of the hormone.

Thirdly, patients can also choose some drugs to dilate blood vessels to improve microcirculation, and drugs to inhibit platelet aggregation.

1. About 20% are self-limited, and the disease has been stabilized at the time of discovery, and such patients can be followed up for observation if there are no comorbidities. In the early stage of the disease, the presence of upper respiratory tract, lung or other organ infection factors should be effectively controlled, which may have certain significance to prevent the development of the disease. Patients with a high suspicion of tuberculosis infection should also be treated with tuberculosis**.

2. Adrenocorticotropic hormones. Hormones are still the main drugs for the activity of this disease, and timely medication can effectively improve symptoms and alleviate the condition. Generally, oral prednisone is 1mg kg per day, taken in the morning or in divided doses, maintained for 3-4 weeks and then gradually reduced, 5%-10% of the total amount is reduced every 10-15 days, and the decrease in erythrocyte sedimentation rate and C-reactive protein tends to be normal as the indicator of reduction, and the dose is reduced to 5mg-10mg per day, which should be maintained for a period of time.

If the conventional dose of prednisone is ineffective, other dosage forms can be changed, and critically ill patients can even be given a large dose of intravenous shock**, but it is necessary to pay attention to adverse reactions such as Cushing's syndrome, susceptibility to infection, secondary hypertension, diabetes, psychiatric symptoms and gastrointestinal bleeding caused by hormones, and long-term use should prevent osteoporosis.

3. Immunosuppressants. Adrenocorticosteroids alone are less effective, or immunosuppressants may be used to increase efficacy and reduce corticosteroid dosage, and the most commonly used drugs are: cyclophosphamide, azathioprine, and methotrexate.

In critically ill patients, cyclophosphamide and azathioprine are given 2 mg to 3 mg kg per day, and cyclophosphamide can be administered** every 4 weeks in body surface area. Methotrexate 5 mg to 25 mg per week can be given intravenously, intramuscularly, or orally. A new generation of immunosuppressants, such as:

There are no large clinical samples reported on cyclosporine A, Xiaoxi, leflunomide, etc., and the efficacy needs to be confirmed. Severe cases can endanger life and cause major health hazards, and it is believed that once Takayasu's arteritis is diagnosed, the combination of immunosuppressants and hormones should be actively started as soon as possible. Even with clinical remission, immunosuppressant maintenance should be continued for a long time, and adverse drug reactions should be noted.

4. Vasodilation and anticoagulation improve blood circulation. The use of vasodilator and anticoagulant drug support** can partially improve some clinical symptoms of patients with obvious vascular stenosis, such as: dibazole 20mg, 3 times a day; Tolatolin 25mg-50mg, aspirin 75mg-100mg, once a day, dipyridamole (dipyridoxine) 25mg, 3 times a day, etc.

Patients with high blood pressure should be aggressively controlled.

5. Percutaneous transluminal angioplasty. It has opened up a new way for the treatment of Takayasu's arteritis, and has been applied to renal artery stenosis and abdominal aorta and subclavian artery stenosis, etc., to obtain good curative effects.

The above is an introduction to the method of multiple Takayasu's arteritis**.

Hello: From your description, it is brachiocephalic multiple Takayasu's arteritis, which is an autoimmune disease that mainly invades large blood vessels such as brachiocephalic arteries, abdominal aorta, pulmonary artery and renal artery, and is a self-limiting disease. At present, you need to pay attention to the control of ESR level, that is, to control autoimmune inflammation, the main conservative method is hormone plus immunosuppressant to control ESR in the normal range, and anticoagulant or antiplatelet aggregation drugs need to be used to prevent thrombosis, if there are ischemic complications caused by arterial stenosis, surgery or intervention may be required to intervene.

Generally speaking, the disease cannot be **, but the immune response in the body gradually decreases with age and may disappear after the age of 40. At present, the main focus is to control immune inflammation and prevent the occurrence of complications.

If you need it, please come to our hospital and we will be happy to help you.

Dr. An Qian of the Fifth Affiliated Hospital of Zhengzhou University solemnly reminded that because the patient cannot be seen face-to-face, and the old state of the old state cannot be comprehensively relieved, the above suggestions are for reference only, and the specific diagnosis and treatment must be carried out in the hospital under the guidance of the doctor! ）

Takayasu's arteritis is a systemic disease that should be based on internal medicine, and surgery should only be based on vascular lesions caused by the disease.

1.Principles of Internal Medicine.

1) Anti-inflammatory** Effective control of infection is beneficial to prevent the progression of the disease.

2) Hormones have a good effect on patients in the early or active stage, and improve symptoms in the short term. Oral prednisone, dexamethasone, etc.

3) Immunization**.

4) Vasodilators to improve blood circulation in the brain and limbs.

5) Antiplatelet drugs: aspirin, etc.

6) Antihypertensive drugs This disease does not have a good effect on one antihypertensive drug, and more than two drugs need to be used together.

2.Percutaneous transluminal angioplasty.

At present, ** renal artery stenosis and abdominal aorta, subclavian artery stenosis, etc., have been used to obtain good curative effects. Balloon dilation is widely used, but stent implantation needs to be used with caution due to the characteristics of arteritis.

3.Surgery**.

Surgery is usually performed after the lesion has stabilized**, including normal body temperature, erythrocyte sedimentation rate, white blood cell count, and IgG. The principle of surgery is to reconstruct the arteries while the organ function has not yet been lost.

1) For the cephalic brachial type, extrathoracic or intrathoracic artificial vascular reconstruction, intimal thrombectomy, etc. can be performed.

2) Patients with severe stenosis of the thoracic or abdominal aorta can undergo artificial vascular reconstruction.

3) For patients with renal artery stenosis, kidney self-transplantation or revascularization can be performed, and nephrectomy can be performed for patients with obvious atrophy of the affected kidney.

4) Coronary artery stenosis can be treated with coronary artery bypass grafting or stenting.

1. Clinical**:

Although there have been obvious inflammatory reactions such as vascular wall proliferation and thickening in the brachiocephalic artery, thoracoabdominal aorta, renal artery and other parts, it has not caused obvious ischemia of important organs such as heart, brain, kidney, and lung, nor has it led to pathological changes in these organs. During this period, the combination of traditional Chinese and Western medicine is actively used for 3-5 years, and the vast majority of patients can benefit for life, and their quality of life is no different from that of normal people, and they can complete various heavy physical activities and exercises. As long as they are eligible, the vast majority of them can obtain clinical **.

2. Clinical effect:

Takayasu's arteritis is relatively severe, with severe narrowing or dilation, or even occlusion of blood vessels, combined with a certain degree of heart, brain, lung, and kidney damage, but it does not lead to organ failure such as blindness, severe cerebral infarction, cerebral hemorrhage, renal atrophy, uremia, etc. At this time, the active use of integrated traditional Chinese and Western medicine** can still obtain very significant results, so that Takayasu's arteritis patients can participate in general life and work, but can not participate in heavy physical activities and exertional exercises, most patients can still prolong their lives, so that the quality of life of patients is basically close to normal.

3. Clinically effective:

Takayasu's arteritis is severe, and blood vessels such as the brachiocephalic artery, thoracoabdominal aorta or renal artery are widely affected, and the arterial wall is scarred and fibrosis, resulting in irreversible narrowing or occlusion of the lumen, and serious complications of important organs such as the heart, brain, lungs, and kidneys, and the function is also impaired. However, after active **, the blood supply to vital organs can still be improved, the function can be significantly restored, and the patient's survival time and quality of life can be significantly improved, but can not participate in general work and physical activities, and can only do light daily life work.

4. Clinical ineffectiveness:

Takayasu's artery is very severe, with extensive involvement of blood vessels such as brachiocephalic arteries, thoracoabdominal aorta, renal arteries or coronary arteries, irreversible severe stenosis or occlusion of the lumen, and patients with blindness, severe heart failure, severe cerebral infarction, severe renal atrophy, and frequent angina pectoris. After positive **, the blood supply to vital organs is not significantly improved, or the function of important organs cannot be significantly restored, which can only prolong the survival time of patients and cannot improve the quality of life.

Inflammation of large arteries can occur, and there is a disease called Takayasu's arteritis. Takayasu's arteritis is a chronic disease caused by branches of the aorta, it is mainly caused by inflammation of the arteries of the blood vessels, and it is also multiple, because the location of the lesion is different, its manifestations are also different, and most of the people who can cause inflammation are young women. Takayasu's arteritis is very difficult to cure, because it can be achieved through inflammation, no longer continue to damage our organs, maintain a normal life, and if there is a disease, we should go to the hospital**.

Aorta arteries can affect our lives and will affect our body and mind, **Takayasu's arteritis must cooperate with the doctor** to reduce their pressure. Pay more attention to rest, Takayasu's arteritis is a systemic disease, should be used in internal medicine, the best surgery will cause vascular lesions, internal medicine should first control its inflammation, prevent viral infection, in the next step with hormones ** is also very good for early patients, can improve its inflammation in the short term, you can take some relative drugs to prevent it from spreading. <>

It is also necessary to do a good job of immunity, eat more vegetables, fruits, improve our immunity, have antiviral effects, anti-vascular drugs can improve normal operation, platelets and other drugs, eat some aspirin, etc., these anti-blood pressure drugs, its effect is not good, it must be combined with more than two to use together, to achieve the effect of Takayasu's arteritis. <>

For example, patients with arteritis of the head can be reconstructive surgery or removal surgery, such as severe chest patients can be revascularized, so that our disease is also very good. If Takayasu's arteritis will have some symptoms such as body fever, especially weakness, muscle pain, vomiting and so on, you can take some drugs to control this condition, we must go to the hospital for examination, such as people under the age of 40 will especially occur this symptom, eat some hormones under the doctor's consultation, and surgery can be alleviated.