Which is more serious, myelofibrosis or myeloma

There is not much comparison, but in terms of survival time, myeloma survival time is shorter.

Myelofibrosis (MF) is abbreviated as myeloid fiber. It is a myeloproliferative disease caused by collagen hyperplasia in bone marrow hematopoietic tissue, and its fibrous tissue seriously affects hematopoietic function. The disease has different degrees of bone marrow fibrous tissue hyperplasia, as well as extramedullary hematopoiesis that mainly occurs in the spleen, followed by the liver and lymph nodes, the typical clinical manifestations are erythrocyte and myelocytic anemia, and there are more teardrop-shaped red blood cells, bone marrow aspiration often appears dry pumping, the spleen is often obviously enlarged, and has different degrees of bone sclerosis.

This disease is a rare disease with an incidence. The age of onset is usually between 50 and 70 years, but it can also occur in infants and young children, and is slightly higher in males than in females.

Multiple myeloma (MM) is a malignant plasma cell disease in which tumor cells arise from plasma cells in the bone marrow, which are cells where B lymphocytes develop to their final functional stage. Therefore, multiple myeloma can be classified as B lymphocytic lymphoma. Currently, the WHO classifies it as a type of B-cell lymphoma called plasma cell myeloma Plasmacytoma.

It is characterized by dysplasia of bone marrow plasma cells with overproduction of monoclonal immunoglobulins or light chains (M-proteins) and, rarely, unsecreted MM without M-protein. Multiple myeloma is often associated with multiple osteolytic lesions, hypercalcemia, anemia, and renal impairment. Due to the inhibition of normal immunoglobulin production, it is prone to various bacterial infections.

The incidence is estimated to be 2 3 100 000, the male-to-female ratio is: 1, and the majority of patients are 40 years old.

In the middle and advanced stages of myelofibrosis, the anemia will become more severe, and patients will experience symptoms of pallor, fatigue, weakness, shortness of breath after activity and palpitations. People with advanced myelofibrosis develop thrombocytopenia, so they often bleed and,** often have purpura or ecchymosis. Splenomegaly is evident.

There may be a feeling of tightness and distension in the upper abdomen, or the spleen may grow too quickly. Patients will have severe pain due to local splenic infarction. Hyperuricemia can also cause renal colic and gouty arthritis.

At the same time, patients with advanced myelofibrosis may also have fever, mainly due to infection. Some patients also have unexplained diarrhea. Increased metabolism can cause low-grade fever, night sweats, tachycardia, etc.

Some patients may also have an enlarged liver, which accounts for about 50% to 70%, mostly mild to moderate swelling and portal vein thrombosis. Patients with myelofibrosis may experience panic, discomfort, and pallor in the advanced stages of the disease, and may also have anemia, chest tightness, and shortness of breath. In addition, patients may also lose significant weight.

Most patients with myelofibrosis have a slow onset and may have subtle symptoms in the early stages, with more organs involved in the later stages of myelofibrosis, which manifest as gradual fatigue, weakness, emaciation, and weakness. Patients may have bone pain, arthralgia, low back pain, and renal colic. Hepatosplenomegaly causes abdominal pain and abdominal masses.

Hemorrhage, anemia, pallor and mucous membranes, shortness of breath, purpura. Patients with secondary infections develop fever. If the patient has intracranial hemorrhage, they will have a sudden headache and loss of consciousness.

Myelofibrosis is a myeloproliferative disorder caused by collagen hyperplasia in the hematopoietic tissue of the bone marrow and its fibrous tissue obstructing hematopoietic function. It is clinically characterized by juvenile erythrocytic and granulocytic anemia with teardrop-like red blood cells. Bone marrow aspirate often presents with dry pumping, splenomegaly, and varying degrees of osteosclerosis.

The prognosis for myelofibrosis is poor. At present, there is no specific drug that can completely ** it. Myelofibrosis** includes blood transfusions, platelet transfusions, and hemostasis; Erythropoietin and protein anabolic steroids are used to promote bone marrow hematopoiesis.

Patients with megasplenism and portal hypertension can undergo chemotherapy or splenectomy, oral thalidomide for immunomodulatory and antineoplastic therapy, and hematopoietic stem cell transplantation if available.

Spleen and hepatomegaly, bleeding symptoms, etc. Enlargement of the spleen and liver, you will feel a feeling of swelling in the abdomen; Bleeding symptoms, purpura and ecchymosis due to thrombocytopenia.

The symptoms are very obvious, and there will be different symptoms, the body will become thinner and thinner, and the complexion will be very poor.

Patients with myelofibrosis reach the middle or advanced stage, the symptoms are already more obvious, and the patients will have more severe anemia. Especially after outdoor activities, there will be obvious symptoms such as dizziness and physical weakness, mainly manifested by chest tightness and shortness of breath, pale complexion and other phenomena. In the advanced stage, leukemia may also be induced, so myelofibrosis appears, and it must be detected early**.

In the middle and advanced stages of myelofibrosis, the degree of anemia will become more and more severe, and the patient will have symptoms of paleness, fatigue, weakness, shortness of breath after exertion, and palpitations. Patients with advanced myelofibrosis will have thrombocytopenia, so they often have signs of bleeding and,** purpura or ecchymosis.

Splenomegaly is more obvious, there may be a feeling of fullness in the upper abdomen or the spleen enlarges too quickly, and the patient will experience severe pain due to local infarction of the spleen. Hyperuricemia can also cause renal colic and gouty arthritis.

At the same time, patients with advanced myelofibrosis can also have fever, most of which is due to infection. Some patients also have unexplained diarrhea, and increased metabolism can cause low-grade fever, night sweats, tachycardia, etc.

Some patients may also have hepatomegaly, which can account for about 50% to 70%, and most of them are mild to moderate enlargement, and portal vein thrombosis may form.

At this time, the body's immunity will be reduced, and at this time, it will be infected with a lot of viruses, and at this time, there will also be symptoms of fever. Severe anemia can also occur, and entering the advanced stage will also cause blood function failure, which will lead to hepatosplenomegaly.

The symptoms are dizziness and nausea, weakness in the limbs, chest tightness and shortness of breath, paleness, and anemia, and the resistance will get worse and worse, and the high fever will not go away, and some organs will directly fail.

Fatigue, shortness of breath after exertion, palpitations, pallor, thrombocytopenia and other symptoms are the most common symptoms.

Anemia, paleness, fatigue, bleeding from organs, indigestion, infection, and coma in severe cases.