Is deafness a genetic disorder? Is there anything to do with deafness and genetics?

Hello, there are many causes of deafness, which can be divided into:

1) Congenital common congenital malformations, including malformations of the outer ear and middle ear, such as congenital atresia of the external auditory canal or hypoplasia of the tympanic membrane, ossicle, cochlea, vestibular window, etc., which are related to genetic factors and gene mutations.

2) Acquired obstruction of the external auditory canal, such as cerumen embolism, bone warts, foreign bodies, tumors, inflammation, etc. Purulent or non-purulent inflammation of the middle ear causes the middle ear to impair, or ear trauma damages the ossicular chain, benign or malignant tumors or otosclerosis of the middle ear.

Hope mine can help you.

Hereditary deafness refers to deafness due to genetic and chromosomal abnormalities. This disorder is caused by changes in the genetic material of the parents, including the chromosomes and the genes located in them, which are passed on to the offspring, and occurs in a certain number of grandchildren.

Some of this is congenital, but it can also be caused by trauma.

Hereditary deafness can be simply understood as deafness inherited from parents. Why, then, do some parents who are congenitally deaf give birth to children who are not hard of hearing, while others who are normal to hearing give birth to children who are deaf? What about how many children can be congenitally deaf in some families, while there is only one deaf person in others?

In addition to the fact that some people with congenital deafness are not caused by genetic factors, another important reason for this phenomenon is that the inheritance mode of hereditary deafness is relatively complex, and the genetic law can not be seen only from the analysis of a family or a family.

The material basis of human heredity is chromosomes, which are present in the nucleus of the cell, with a total of 23 pairs, of which 22 are symmetrical autosomes, and 1 pair is related to sex, called sex chromosomes. Half of these chromosomes come from the father and half from the mother. That is to say, when parents transmit genetic information to their children, they first divide their chromosomes into two equal groups, and then pass them on to the next generation in random combinations, so that some characteristics of parents are passed on to their children.

Of course, some of these traits are beneficial to the next generation, and some are harmful to the next generation. Deafness is a trait that is harmful to children.

There is a certain relationship between deafness and heredity, but the specific hereditary probability cannot be determined. If chromosomes are tested during pregnancy, it may be possible to screen for deafness. Hereditary congenital deafness.

At present, there is no ** method, and most of them are used to wear hearing aids or cochlear implants.

Deafness and heredity should be related, not passed down from generation to generation. It seems to have something to do with genes.

Deafness refers to the loss of hearing, some of which are hereditary and some of which are not, as follows:

1. Acquired factors: such as deafness caused by degeneration of the ear nerve caused by infection, trauma or circulatory disorders, which will not be inherited due to acquired factors;

2. Genetic factors: If deafness is caused by changes at the genetic level, that is, deafness caused by mutations in deafness genes, and the mutations can be inherited to the next generation. That is, the mutated and pathogenic deafness gene is inherited to the children with the separation of the parents' genes, and is carried by the children, and the deafness will be inherited at this time, which is also the basic genetic principle of hereditary deafness.

As in autosomal dominant inheritance, the parents carry the disease-causing gene, and when one parent separates the gene, the disease-causing gene is passed on to the child, and the child also carries the mutated gene for deafness, which will cause the child to become deaf. If it is autosomal recessive, the child needs to carry more than 2 allele mutations to inherit deafness. Some deafness is hereditary, usually refers to hereditary deafness, that is, it is related to genetic abnormalities, this hereditary deafness is usually congenital, children will be born with hearing abnormalities, hearing loss, and even total deafness, usually common in both ears of severe sensorineural deafness, the most important way to do this is to consider cochlear implantation to improve the child's hearing after the diagnosis is clear.

Generally, cochlear implantation can be done at about one year old, and appropriate language training can be carried out after doing it, so that the child's hearing can be improved, and the child has normal hearing, so as not to delay the child's language development, so as to avoid the problem of deafness and muteness. The main way to do this is to consider cochlear implants to improve hearing, so that the impact on language development can be avoided, so that the child can speak normally, and thus improve the quality of life of the child.

Expert tip: Deafness is hereditary, related to genetic abnormalities, hereditary deafness, after the child is born, it will be found that there are hearing abnormalities, hearing loss and even total deafness, after the diagnosis is clear, you can consider cochlear implantation to improve the child's hearing.

There are a wide variety of genetic disorders admitted to the Department of Otology Neurosurgery, including: hereditary deafness (including congenital deafness, late-onset deafness; There are more than 400 syndromes accompanied by deafness and other signs of otal neurosurgery, such as Pendred syndrome, Uher syndrome, Waardenburg syndrome, Alport syndrome, gill-ear-kidney syndrome, Treacher Collins syndrome, charge syndrome, etc. Taking congenital deafness as an example, there are 1 3 children with deafness in every 1000 newborns, of which 65% are hereditary deafness, with the continuous discovery of more deafness genes, this proportion is still increasing, at present, the genetic testing of deafness at home and abroad has been included in the routine items of clinical testing, and even some developed countries and developed regions in China have included the detection of deafness genes into the scope of general screening of newborns.

Previously, it was thought that genetic diseases were incurable. In recent years, with the progress of modern medicine and molecular biology, medical geneticists have gradually deepened their understanding of genetic diseases, and have elucidated the pathogenesis of some genetic diseases, thus making it possible to intervene in genetic diseases. For example, the A1555G and C1494T mutations in the mitochondrial MT-RNR1 gene are the main mutations in mitochondrial maternal deafness, and female carriers will pass the mutation to their children, with daughters continuing to pass on to their offspring; Carriers are sensitive to ototoxic drugs, mainly aminoglycosides (gentamicin, streptomycin, etc.); Once the carrier receives these drugs**, there is a risk of deafness, and in severe cases, a single shot can cause deafness.

Therefore, the diagnosis of a patient with deafness caused by mitochondrial MT-RNR1 gene mutation through deafness gene diagnosis can provide an early warning to the whole family, so as to avoid the recurrence of drug-induced deafness in the whole family and its offspring. At present, there are also very effective intervention methods for patients with congenital deafness, wearing hearing aids and cochlear implants is the most effective means, as the saying goes, ten deaf and nine dumb, but at present, through early diagnosis and intervention, it has been possible to achieve "deaf but not dumb", most children with congenital deafness can communicate normally through speech and study in ordinary schools through effective intervention and **.

The diagnosis and treatment of genetic diseases focus on prevention, and genetic clinics have been set up in some medical centers in China to detect and diagnose hereditary diseases by using genetic diagnosis technology (venous blood is drawn from patients and their families, and amniocentesis is required for prenatal diagnosis), and through genetic counseling and marriage and childbirth guidance, the most appropriate decision is selected to reduce the birth risk of the child.

A: Generally speaking, deafness is caused by acquired factors, and deafness is not inherited in this case (except for congenital deafness).

Some deafness is hereditary, some are not. Deafness can be divided into congenital deafness and acquired deafness, congenital deafness is deafness at birth, mostly hereditary, because one or both parents carry the deafness gene, inherited to their children.

The father and mother who carry the deafness gene are not necessarily deaf, that is, both parents are hearing normal, but children can also be deaf. Acquired deafness occurs after birth, most of which cannot be inherited, and only a few are hereditary.