Ask about the genetic aspects of vitiligo

Vitiligo has a certain genetic background and may be caused by an autosomal dominant gene abnormality, but from the perspective of legacy, heredity is only one factor in the onset of vitiligo. Vitiligo will have a certain chance of heredity, but the heredity is relatively small, generally about 3%-5%, simple genetic factors do not necessarily cause vitiligo, vitiligo is a combination of internal and external factors in the genetic background.

Hello, vitiligo, also known as vitiligo, is mainly localized, sporadic, generalized, acral and facial types. Vitiligo has a certain correlation with heredity, but genetic factors only account for a small part of the hair element, generally about 3%-5%. It is recommended to go to a professional hospital** to be fine.

I'm a good vitiligo patient myself. My dad had gray hair at a very young age. But I have several siblings, and I have vitiligo, and my children don't have it. Personally, I believe that vitiligo is hereditary, but at the same time it is a low probability.

Previously consulted a professional doctor with a similar question, doctor specialty:

Vitiligo is a relatively common acquired depigmented mucosal disease, which is not fully understood, but it is determined that genetic factors have a certain relationship with the occurrence of vitiligo. The evidence is multiple:

1. Vitiligo will have a family history and family gathering, and the genetic probability of vitiligo reported abroad is about 20%-40%, and it is about 3%-20% in China.

2. Identical twins suffer from vitiligo at the same time, which also confirms the genetic predisposition to vitiligo.

3. The genetic research of vitiligo has confirmed the susceptibility gene locus of vitiligo, and also confirmed that the occurrence of vitiligo is related to heredity, and heredity is mainly polygenic inheritance, that is, heredity is not the only factor, because the first-degree relatives have vitiligo, and the probability of children suffering from vitiligo is higher than that without a family history of vitiligo, but it is not absolute, acquired environmental factors, including neuropsychiatric factors and autoimmunity, are also involved in the occurrence and development of vitiligo, so vitiligo is a polygenic genetic disease, and there are certain factors in heredity, but not the only and all factors.

Vitiligo runs in families, but it is not a genetic disease.

The onset of vitiligo is indeed related to genetic factors, but it is not a simple monogenic genetic disease, but a complex disease with multiple genes working together, and as many as 50 vitiligo susceptibility genes have been discovered. In the genetic context, a combination of autoimmune abnormalities, oxidative damage, and environmental factors contribute to the onset of vitiligo. Therefore, genetic factors are only one of the factors that affect the onset of the disease.

If a parent has vitiligo, their offspring will have a higher chance of developing vitiligo than the general population, but they will definitely get the disease.

Data Extensions

The treatment of vitiligo is general** such as avoiding precipitating factors, drugs ** such as glucocorticoids, physical **, surgery**, etc.

1.General**: excessive stress, mental tension, trauma, sun exposure, etc. can induce vitiligo, so vitiligo should avoid sun exposure, trauma, maintain a comfortable mood, and at the same time need to supplement vitamin B, vitamin E, etc.

2.Drugs**: For vitiligo, topical glucocorticoids such as hydrocortisone butyrate or tincture can be used to remove whitening, which helps to restore the color of ** and is suitable for advanced skin lesions.

There are also calcineurin inhibitors such as tacrolimus ointment, which has a good effect on the opposite neck. Drugs taken internally include prednisone. Medications should be used under the guidance of a doctor.

3.Physical**: such as 308 excimer laser, suitable for all types of vitiligo**.

4.Surgery**: such as microdermal transplantation, autologous epidermal transplantation, etc. Suitable for stable vitiligo.

Patients with vitiligo are advised to see a doctor in a timely manner, and they need to be regulated under the guidance of a doctor**.

The probability of vitiligo inheritance is very low, and you will understand by looking at the following sentence: Vitiligo is a localized white patch that occurs due to depigmentation, making the local ** white patch. In medicine, this lesion is often referred to as depigmentation.

As can be seen from this, vitiligo is mainly acquired, so don't worry too much. As parents, we all want our children to be healthy after birth, even if there is a 1 in 10,000 chance that we don't want to see.

The following paragraph is what I found from Dalian Jingzhi Wangcheng ** Disease Hospital, and the hospital's experts said it. Hope it helps! At the same time, I wish your child good health in advance.

1. Marriage partner.

Patients with vitiligo should try to avoid having a history of vitiligo on both partners when choosing a partner.

2. Pregnancy time.

The onset of vitiligo has obvious seasonality, mostly aggravated in winter and autumn, and reduced in summer, compared with other seasons, the patient's own condition in summer is superior, and appropriate sweating at this time is also conducive to vitiligo, therefore, vitiligo patients choose summer pregnancy is the most suitable time.

In addition, it is important to avoid indiscriminate use of drugs during pregnancy, as patients often take drugs during vitiligo attacks, especially some anti-cell proliferative drugs and immunosuppressive drugs have a very adverse effect on the fetus. In this case, you need to consult with a specialist.

3. Do a good job.

Good physical condition is the capital of our fight against the disease, so we need to strengthen exercise to enhance our own resistance. At the same time, it is also necessary to eat more foods that are good for vitiligo**.

4. Be familiar with precautions.

Precautions refer to some contraindications for vitiligo, such as what you can't eat in your diet, resolutely don't eat what you can't eat, and resolutely don't do what you can't do. At the same time, try to choose green foods when choosing food. This is the reason why the incidence of vitiligo is lower in rural areas than in urban areas.

5. Environmental factors.

Environmental factors are also important factors in the pathogenesis of vitiligo. There are two types of environmental factors: one is the external environment and the other is the internal environment, and the external environment refers to factors such as trauma and climate. Factors such as psychological state and daily diet belong to the internal environment.

From the above points, it can be seen that the fundamental thing to reduce the probability of vitiligo heredity is to need patients to understand the precautions for vitiligo, in general: "We should do more if it is good for vitiligo, and we must not do anything that is harmful or aggravated by vitiligo", so that this sentence, the genetic probability of vitiligo is almost zero.

In order to better prevent vitiligo inheritance to the next generation, only vitiligo is the key, Dalian Jingcheng Hospital brings together well-known vitiligo experts and professors from all over the country, the experts through years of experience and analysis of vitiligo, combined with advanced medical equipment, to carry out thorough research and analysis of patients' symptoms, and develop a perfect plan.

In closing, it is best to go directly to the hospital specialists.

Vitiligo is not a hereditary disease, and the pathogenesis of vitiligo is currently unknown, but it is certainly not related to chromosomes.

Hello, to be precise, vitiligo is related to genetic factors, but it is not that parents have vitiligo, children will definitely have vitiligo, because according to studies, parents have vitiligo, and the probability of children suffering from vitiligo is only 3% to 7%. Vitiligo is a combination of internal and external causes of hypopigmentation in a genetic background, and parents have vitiligo, but children do not necessarily suffer from vitiligo. However, offspring with a family history of vitiligo must pay attention to avoid various factors that induce vitiligo, such as mental stress, trauma and sun exposure.

Hello, vitiligo is a chronic ** disease, it has family hereditary, but it is not the main cause of the disease, heredity accounts for 3%-5% of its incidence. Genetic factors alone do not necessarily lead to vitiligo, vitiligo in the context of heredity, a combination of internal and external factors, the interaction of various factors will lead to the appearance of vitiligo. Internal factors are beyond our control, so we need to pay more attention to the role of external factors.

For example, environmental factors, lifestyle, working environment, eating habits, mental state, air, water source, etc.

In fact, genetics is only one factor in the onset of vitiligo. According to studies, parents with vitiligo are only likely to have vitiligo. In the process of receiving patients in the Department of Concord **, Director Yard Rubber Closed Tu Yating also found that there are very few patients with real genetic factors, and the probability of inheritance to the next generation is not as great as that of other hereditary diseases.

Because in addition to genetics, environmental factors such as lifestyle, dietary habits, mental state, etc. also have an important impact on the onset of vitiligo. Clinical studies have shown that the disease is the result of a combination of genetic and environmental factors. Therefore, even if there are genetic factors, as long as the influence of environmental factors is eliminated, the disease may not occur, so vitiligo patients can marry and have children.

The hereditary probability of vitiligo in China is 2-4%, and vitiligo has a certain background of inheritance, which may be caused by an autosomal ulnar bond gene abnormality, but from the perspective of genetics, heredity is only a factor in the diagnosis of vitiligo.

It is uncertain whether you will be genetically inherited, because the probability of this inheritance is relatively low, and it is recommended that you do not pay too much attention to this problem.