What is the specific activity of Jin Lei Saizeng?

Jin Lei. The specific activity of Saizeng powder is about and about, and the specific activity of water agent is, which is easy to calculate from the manual. If Jin Lei Sai added propaganda powder and water agent, it would be false propaganda.

Before 1993, the determination of specific activity was based on animal experiments, and the error was very large, and a certain amount of finished growth hormone could not correspond to a fixed activity, and the activity could only be measured by SIU IU. With the improvement of genetic engineering technology, a certain amount of growth hormone products can be achieved corresponding to the fixed activity, and the quantitative determination is more accurate, so in 1993, the international regulations used the content (mg) to measure the activity, and replaced the original IU label with milligrams (mg), and at the same time fixed the specific activity uniformly.

China's 2010 edition of the pharmacopoeia stipulates that the finished product of growth hormone is only marked with milligrams, and the specific activity is fixed, so the specific activity is the passing line of growth hormone products. With the advancement of technology, data on growth hormone specific activity greater than are also beginning to appear.

With the progress of domestic technology and in line with international standards, China's 2010 edition of the pharmacopoeia stipulates that the finished products of growth hormone are only labeled with milligrams, and the specific activity is fixed, so the specific activity is the passing line for the listing of growth hormone products, which can only represent qualified products, not the highest quality.

The "specific activity" in growth hormone is the ratio of activity (IU) to mass (mg), which is one of the attribute factors used to determine the measurement specifications of growth hormone. Higher specific activity means better quality and efficacy of biopharmaceuticals.

The 2015 pharmacopoeia clearly stipulates that the growth hormone specific activity must be determined by the pituitary rat body weight method and the pituitary rat tibia method. Therefore, the specific activity is measured by animal experiments, not according to the instructions.

Based on the appellate viewpoint, I believe that most parents have understood what the specific activity of growth hormone is, and at the same time, it should be known that the specific activity value of growth hormone is obtained by testing rather than calculated by the manual. Therefore, parents should not blindly choose to be more active than growth hormone, and must figure out the principle. If you really don't understand, you can go to the hospital and ask a professional doctor.

The average specific activity of several batches of Kinsey water agent has been reached, the average specific activity of several batches of powder has been reached, and the specific activity of Saizeng powder has been reached 20 years ago, and has been selected as the national quality standard of growth hormone powder by the China Inspection and Inspection.

Recombinant human growth hormone** does not increase the prevalence of type 1 diabetes, but recombinant human growth hormone** reduces insulin sensitivity and increases insulin resistance in the long term. Some patients have impaired fasting blood glucose and impaired glucose tolerance, but most of them are temporarily reversible, rarely develop diabetes, and generally return to normal after stopping growth hormone. The vast majority of children maintain blood glucose in the normal range in recombinant human growth hormone**.

At present, data at home and abroad show that recombinant human growth hormone does not increase the risk of new malignancies (such as leukemia, central nervous system tumors or extracranial malignancies) in patients without tumors. Current data do not suggest that recombinant human growth hormone increases the risk of tumor recurrence. Recombinant human growth hormone** also does not affect brain tumors, craniopharyngiomas, and leukemia**.

Growth hormone aqueous supplements are more advantageous. First of all, the structure is more natural, the water agent does not need to be freeze-dried, and the structure is closer to the natural GH (secondary structure alpha helix structure literature), so the antibody is not easy to produce (the water agent is currently zero detection of antibodies), and the clinical specific activity is higher (Sai water agent, so it can better ensure the clinical efficacy. The powder will produce antibodies, and long-term use is easy to produce immune complexes and safety risks, so the water agent ensures the safety of medication.

Correct measurement of specific activity (page 172 of Chinese Pharmacopoeia 2015 edition): The specific activity of growth hormone must be determined by the pituitary rat weight method and the pituitary rat tibia method. Therefore, the specific activity is measured by animal experiments, not according to the instructions. If you pay attention to the instructions, according to Ansumeng's algorithm, the specific activity of each specification of the product will be different, which is obviously unreasonable, it is all produced in the same batch, and the ratio will change if it is packaged in different bottles?

An Sumeng advocated that it was higher than live, which was calculated according to the calculation method of the specific activity in the manual, and there was no scientific basis.

Growth hormone takes at least 1-2 years, and the cost is relatively high, and the cost is different for different children, different dosages, and different costs. Different manufacturers, the quality of drugs is different. The quality of growth hormone mainly depends on the specific activity, and the higher the specific activity, the better the quality.

But it's not that the quality is good, it's expensive, among which Ansu Meng growth hormone is very cost-effective, and it is the growth hormone with the highest activity than the activity, which is relatively cheap, and the cost is about 20,000 yuan a year, and the specific amount depends on the size of the drug dose. The specific activity of Saizeng growth hormone water injection is also yes, there is one less dissolution step when injecting, and it is a little more convenient to use, but it is too expensive, about 2 times more than Ansumeng, and some costs 70,000 or 80,000 a year. There is no difference in the efficacy of growth hormone with the same activity, it is recommended that you use Ansumeng, there is no need to spend so much money because there is one less step in the injection.

Such drugs should be consulted in hospitals and pharmacies in a timely manner. It is recommended to eat more fresh vegetables and fruits, drink more water, avoid spicy food, pay attention to rest, maintain emotional stability, supplement multivitamins, and enhance immunity as soon as possible**.

Is that okay?

A basic idea: there is no direct answer to the cost of growth hormone.

First of all, please make a basic point clear: how much does it cost to inject growth hormone, there is no one problem on this issue.

1. Direct numerical answers.

The cost of growth hormone is not a simple number, but a complex scientific question. Those parents who want to get a certainty**, please look at the matter of growth hormone more rationally and scientifically.

For example, there are a range of indications for growth hormone**, and the dosage of growth hormone will vary depending on the indication**. The US FDA has approved 11 indications for growth hormone, and the first application is growth hormone deficiency. This indication may be better accepted by our parents, which can be simply understood as zinc deficiency and zinc supplementation, calcium deficiency and calcium supplementation, and exogenous growth hormone supplementation if lack of growth hormone.

Taking the use of short-acting preparations in undeveloped children as an example, ** the dosing range for children with growth hormone deficiency is; For diseases not caused by growth hormone deficiency, such as idiopathic short stature, small-for-gestational-age infants, Turner syndrome, short stature due to chronic renal insufficiency, etc., the scope of administration of short-acting preparations is: In other words, the dosage of non-growth hormone deficiency disorders is larger than that of growth hormone deficiency, and the corresponding ** cost is higher.

Dosage and duration of growth hormone for different indications.

Foreign ones are more expensive. Domestic ones are very cheap. Different manufacturers produce factories, ** will be much worse.

In addition, the price of this drug varies greatly from hospital to hospital.

Once upon a time, we were "looking at growth hormone drugs". Today, more and more Chinese children are receiving growth hormone**. According to the latest data survey, let's understand the current proportion of patients with major brands of growth hormone.

Proportion of patients actually choose growth hormone.

In view of the comparison of the above evaluation items, it is not difficult for us to extract the following important information about the selection of growth hormone:

1. The upgrading of growth hormone dosage form has brought better drug feeling and clinical efficacy to the user population, and the overall effect is that water is better than powder, long-acting is better than short-acting, and at present, long-acting is more cost-effective;

2. As a long-term medication, compliance is a crucial part of testing the efficacy of growth hormone, and it is recommended to choose drugs and injection devices that are suitable for children and make children more willing to cooperate with the best drugs;

3. The home injection environment is complex, for safety reasons, if a single growth hormone needs to be used multiple times, it is recommended to choose a growth hormone drug with antibacterial ingredients;

4. Temperature affects the safety and efficacy of growth hormone, it is recommended to choose 2-8 stored drugs and put them in the refrigerator to make it easier to control the temperature;

5. The production hormones made in China have represented the highest quality in the world, and the selection of imported products should be rationally analyzed;

6. Domestic growth hormone has become the choice of the most families in China, and as the earliest company to market growth hormone drugs in China, Jinsai Pharmaceutical currently has the most patients.

How to choose the right growth hormone for your child, have you got it? If you are also worried about your child's height, please also ask parents and friends to take your child to a professional medical institution for consultation and consultation in time.

May the children live up to their expectations and thrive.

You can try to change to other manufacturers' growth hormone. Now the quality of growth hormone is the best, and the one with the highest specific activity is to try it with the specific activity of growth hormone.

Not so good! Seek benefits through kickbacks, and collude with doctors to achieve sales goals! Parents don't be deceived, it has no effect!

Kinsey Pharmaceuticals is a leading genetically engineered pharmaceutical company in China and one of the most innovative pharmaceutical companies in China. It is the only incubation base for new genetic engineering drugs in China and the first demonstration center for quality management of genetic engineering drugs in China.

After 17 years of technical research, Jinsai Pharmaceutical has successively listed the first domestic growth hormone powder, the first growth hormone water in Asia, and the world's first polyethylene glycol long-acting growth hormone with independent intellectual property rights, making China's recombinant human growth hormone series of R&D and production technologies enter the international leading ranks.

Long-acting growth hormone Kinsai is the first major original drug with international competitiveness in China. Kinsey Pharmaceutical's growth hormone products are widely used in 1,200 hospitals in 30 provinces and cities across the country, with a total of more than 100,000 short children in the country, with an average annual height increase of 8-12 cm. In 2015, Kinsey Pharmaceutical's growth hormone series products won the second prize of the National Science and Technology Progress Award.