Does the growth hormone water injection contain preservatives?

The Ansumeng growth hormone water used by the classmate does not contain preservatives, and I heard him say that other brands of water have preservatives.

With the improvement of the production process, the growth hormone aqueous agent can better ensure the activity of the growth hormone protein, but the stability of the aqueous agent is not as good as the powder, many manufacturers will add phenol as a preservative in order to extend the shelf life, phenol belongs to three types of carcinogens, this preservative has strong cell penetration, and has cytotoxicity and reproductive toxicity. Long-term use has a corrosive effect on the ** mucous membrane, and can also inhibit the central nervous system and damage liver and kidney function.

No. Growth hormone has no preservatives, only bacteriostatic agents, which are substances that inhibit the growth of bacteria, and are emphasized in the European and American pharmacopoeias: all injections with multiple doses or multiple uses must be added with bacteriostatic agents.

At present, there are several growth hormone water agents on the market, some of which contain preservatives, and Ansu Meng water agent of Anke Biotechnology does not contain phenol preservatives, which is safer for long-term use. Phenol is difficult to metabolize and easy to accumulate in the body. Although the dosage is within the range set by the state.

Different brands are different, some have preservatives, some don't, early growth hormones are available, and a new water agent in the past two years has no preservatives.

At present, there are many growth hormone manufacturers in China, only Ansumeng growth hormone water is preservative-free, and my cousin is very safe with Ansumeng.

Through research, we found that both doctors and patients are more concerned about the safety of a long-term drug. The second is convenience. Then we think safety is more important for patients.

Since the protein is very unstable in aqueous solution, preservatives need to be added to the aqueous agent to inhibit the reproduction of bacteria and prevent protein denaturation. As a kind of preservative, phenol was originally more commonly used, but due to the toxicity of phenol itself, the literature shows that phenol can cause local lipoatrophy and pigmentation, and long-term accumulation in the body will cause neurological damage and liver and kidney function damage, and some patients will also cause damage to reproductive function. Therefore, the state requires that it should be used with caution or as little as possible.

For those that must be used, countries around the world have also set maximum concentrations. Especially for long-term use, countries around the world are also cautious about the use of phenol. Therefore, the use of phenol as a preservative is no longer advocated in the new growth hormone water supplement.

Ansu Meng Water Agent is a new second generation and the only preservative-free growth hormone water agent, which can avoid the damage to the central nervous system, liver and kidney that may be caused by long-term injection of drugs containing preservatives, ensure the safety of children, and be more conducive to long-term use by children. It is the safest growth hormone water in the world.

At present, China's regulations on the use of injection preservatives are not perfect, and it is understood that they are being improved and approved. Only in Appendix IB of the 2010 edition of the Chinese Pharmacopoeia, it is written: "Intravenous infusion and intracisternal, epidural, and intraspinal injections shall not be added with bacteriostatic agents."

Unless otherwise specified, the injection volume of more than 15ml at one time shall not be supplemented with bacteriostatic ......In most cases, it is safe, but some adverse drug reactions are indeed caused by these bacteriostatic agents, so the safety evaluation of bacteriostatic agents in injections should be strengthened, especially in patients with potential allergies. Due to the toxicity of bacteriostatic agents, the lowest effective concentration should be used in the formulation as much as possible. In other words, it is more general.

There are no strict regulations for the use of bacteriostatic agents for injections.

Ansumeng's powder does not contain phenol, because the powder is aseptically produced throughout the process, and the drug is in a solid state, and bacteria are not easy to multiply, so there is no need to add preservatives; And Ansumeng's water agent also does not contain phenol because of the histidine stabilizer used.

The previous aqueous growth hormone agent contained the preservative phenol in order to preserve, and there was neurotoxicity, nephrotoxicity. In 2018, Anke's growth hormone uses the latest technology, no preservatives, and is the safest growth hormone with active EU standards.

Hello, glad you asked, HGH water contains no preservatives. This is because there are active biopharmaceuticals. When storing, it is necessary to inhibit the growth of bacteria and maintain their activity.

Growth hormone generally contains bacteriostatic agents, not preservatives, bacteriostatic agents are to prevent the growth of bacteria after multiple injections of growth hormone after opening, that is, to prevent growth hormone from being contaminated, which is good for children.

For the preservatives in growth hormone, that is, bacteriostatic agents, as the name suggests, they are limited by technology and technology, and the monitoring source is added to maintain the long-term preservation of the preparation. The common stuffy friend is phenol, and there are relevant regulations on the content in the preparation, which may cause damage to the central nervous system and liver and kidney function.

There are two dosage forms of growth hormone, there are powder and water, the powder is preservative-free, and most aqueous preparations contain phenol preservatives; Phenol, also known as stone carbonic acid, is highly toxic, and studies have shown that long-term use of preservatives may cause risks such as DNA damage to germ cells, central nervous system, and liver and kidney function damage, and these risks will undoubtedly increase further for short children who need to use growth hormone for a long time!

The new second-generation growth hormone aqueous agent of Anxmeng, using the latest international prefilled fibrillation dosage form, is the only water agent in the world that does not add preservatives, which effectively avoids the risks of germ cell DNA damage, central nervous system stool hole and liver and kidney function damage caused by long-term use of drugs containing phenol preservatives, ensures clinical safety, and is more suitable for long-term use by patients.

Growth hormone added preservatives may cause cancer, Johnson & Johnson talcum powder incident is a good example, growth hormone is a special drug, now most of the growth hormone on the market needs to be injected every day, if the growth band hormone quietly contains preservatives, in the long run, large doses of injection, the impact on the baby's body is difficult to assess, I hope that parents must keep their eyes open when choosing growth exacerbium, choose preservative-free growth hormone.

Growth hormone aqueous agents generally contain phenol preservatives, such as sodium benzoate, phenol, etc. These preservatives are considered potentially carcinogenic, but when used in reasonable doses, they have a low risk of causing cancer.

According to the International Agency for Research on Cancer (IARC) classification, sodium benzoate is classified as a Category 2B substance that may be carcinogenic to humans, while phenol is classified as a Category 1 substance that may be carcinogenic to humans. This means that in animal experiments, these substances have been shown to have carcinogenic effects in animals, but their effects in humans still need further research.

Therefore, if the appropriate amount of growth hormone water is used and used according to the doctor's recommendations, its carcinogenic risk is relatively low. However, if used inappropriately or in excess, it may increase the risk of cancer. Therefore, growth hormone water should be used on the advice of a doctor, dressed up and followed the correct method of use.

Studies on growth hormone have shown that the contamination rate is close to 0 within 4 hours after the injection is configured, and the contamination rate is more than 18% in 7 hours, therefore, the specifications of aseptic operation are: 1. The injection should be prepared and used immediately, and it must be used up within 4 hours; 2. There are safety risks in the use of drugs without bacteriostatic agents for multiple uses, so they cannot be used many times. This means that antimicrobial agents must be added to drugs that have been used multiple times.

Jinsai Pharmaceutical Co., Ltd. adds bacteriostatic agents in strict accordance with national standards to ensure the safety of drugs and the high quality of drug efficacy.

There are no preservatives, but they affect bone health.

Some. Some drug manufacturers have added "phenol" as a preservative to growth hormone, the purpose is to prevent the liquid after opening from being polluted and protein denaturation, "phenol" is also called bacteriostatic agent, the 2015 edition of the Chinese Pharmacopoeia also recommends "adding appropriate bacteriostatic agents" and because drug safety is becoming more and more important, the 2020 edition of the Chinese Pharmacopoeia will also put forward the same rigid requirements for adding bacteriostatic agents to protein drugs as other countries and regions. Long-term use of preservative-containing protein drugs is genotoxic and chromosome breaker that can cause DNA damage, and scientists in the United States have advocated the production of single-dose formulations to avoid the addition of phenol preservatives to biologics. It is understood that there is a growth hormone produced by a manufacturer called Ansu Meng that does not contain phenol!

From a professional point of view, the quality of growth hormone is measured by the "total relevant protein content", and it is not said that it contains preservatives or not, which is like "you eat, others ask you if there are pesticides in your meal" is a very unprofessional question.

First of all: since it is recognized by the state that the growth hormone on the market meets the safety standards, there is no doubt about it! Secondly:

The lower the total protein content, the purer and better the quality of HGH. 30% of the total relevant protein content according to the European Pharmacopoeia (minimum standard); The Chinese Pharmacopoeia stipulates that the total related protein content is 13%; Kinsey Pharmaceutical's internal control standard has a total protein content of 10% (the highest standard), which shows that China's domestic growth hormone is better than that of imported ones. Everyone should also believe in Chinese brands!

Chinese people have always misunderstood preservatives, in fact, the European and American pharmacopoeia emphasized: all multi-dose or multi-use injections must be added with bacteriostatic agents. The 2015 Pharmacopoeia published in China also recommends "adding appropriate bacteriostatic agents".

At present, all domestic and foreign growth hormone aqueous companies have selected phenol or cresol as bacteriostatic agents, and the content is controlled within the limit, which can achieve the goal of both safety and effectiveness, with the aim of reducing bacterial contamination during drug storage and operation. Drug regulatory authorities and medical and health authorities in various countries attach great importance to the safety of children's drug use, and it is impossible to protect the interests of any institution. Usually patients** will choose to use water, which requires long-term injection, and the addition of preservatives is responsible for the patient's health.

The pharmacopoeia of various countries clearly stipulates that bacteriostatic agents must be added to drugs for multiple injections. Phenol has been successfully used as a bacteriostatic agent for more than 50 years and is considered to be a safe and effective bacteriostatic agent, which fully meets the strict international requirements for bacteriostatic agents. Phenol is widely used in multi-injection preparations as a commonly used bacteriostatic agent by pharmacopoeia of various countries.

Studies have shown that injections without bacteriostatic agents are quickly contaminated after opening. Multiple injections of the contaminating drug can lead to serious infections and even death.

1. All international growth hormone aqueous agents contain bacteriostatic agents, and multiple injections of single growth hormone are inevitable, and the inexhaustible liquid cannot be preserved, resulting in the waste of a single dose lower than the required dosage, which affects the efficacy.

2. Therefore, the one-time prefilled water agent of Ansumeng without phenol bacteriostatic agent must be used up at one time after opening. However, with only 4 IU and 10 IU, it is not enough for all children with frequent dose adjustments.

3. Saizeng water enhancer is matched with Saizeng electronic pen to achieve precise injection and avoid multiple extraction contamination and storage contamination after opening.

Preservatives, also known as bacteriostatic agents, as the name suggests, are substances that can inhibit the growth of bacteria and prevent the growth of bacteria. Chinese name: growth hormone preservative.

Growth hormone needs to adjust the dose according to the change of body weight, so it is inevitable that a single growth hormone can be used multiple times, in order to ensure the safety of multiple injections, pharmacopoeia of various countries have mandated that bacteriostatic agents must be added to the injection for multiple uses. In accordance with the provisions of the pharmacopoeia, the cassette water is added with an antibacterial formula, which eliminates the risk of infection caused by multiple injections after the powder and prefilled water are opened, and the safety is extremely high. In addition, there is also an injection device with cartridge water on the market - hidden needle electronic injection pen, which can flexibly adjust the dose according to the child's needs, and at the same time the injection does not expose the needle, eliminating the child's fear of injection.

Special process, is preservative-free.

The cost of growth hormone is affected by a number of factors, and it can be said that the cost of growth hormone is completely different from person to person. To put it simply, the child's weight at the time of the child, the reasons for the short stature, the child's age and bone age, whether the child is sexually developed, the duration of the child, and the choice of different brands and dosage forms of growth hormone will affect the child's plan, and the corresponding cost will also change.

On the topic of HGH costs, an important point that has to be mentioned is the choice of HGH dosage form. To put it simply, the three more common dosage forms on the market are powder, short-acting water agent and long-acting water agent.

Each of these three dosage forms of growth hormone has its own characteristics and advantages.

The earliest market in China is growth hormone powder, from 98 to the present, clinical application for more than 20 years, more than 300,000 people of the first application proves that it has a very good efficacy and safety, in the past 5 years, the powder has dropped significantly, becoming a growth hormone dosage form that can be used by short children in China.

Compared with powder, the structure of the water agent is more natural and the quality is relatively higher. Some growth hormone water can be injected with a cryptoneedle electronic pen, which is very helpful in reducing the fear of injection and reducing pain in children's hearts.

Long-acting water is a breakthrough in the research and development technology of growth hormone, which only needs to be injected once a week, giving parents and children a new choice.