Does HGH water injection have preservatives?

Growth hormone needs to adjust the dose according to the change of body weight, so it is inevitable that a single growth hormone can be used multiple times, in order to ensure the safety of multiple injections, pharmacopoeia of various countries have mandated that bacteriostatic agents must be added to the injection for multiple uses. In accordance with the provisions of the pharmacopoeia, the cassette water is added with an antibacterial formula, which eliminates the risk of infection caused by multiple injections after the powder and prefilled water are opened, and the safety is extremely high. In addition, there is also an injection device with cartridge water on the market - hidden needle electronic injection pen, which can flexibly adjust the dose according to the child's needs, and at the same time the injection does not expose the needle, eliminating the child's fear of injection.

Special process, is preservative-free.

The cost of growth hormone is affected by a number of factors, and it can be said that the cost of growth hormone is completely different from person to person. To put it simply, the child's weight at the time of the child, the reasons for the short stature, the child's age and bone age, whether the child is sexually developed, the duration of the child, and the choice of different brands and dosage forms of growth hormone will affect the child's plan, and the corresponding cost will also change.

On the topic of HGH costs, an important point that has to be mentioned is the choice of HGH dosage form. To put it simply, the three more common dosage forms on the market are powder, short-acting water agent and long-acting water agent.

Each of these three dosage forms of growth hormone has its own characteristics and advantages.

The earliest market in China is growth hormone powder, from 98 to the present, clinical application for more than 20 years, more than 300,000 people of the first application proves that it has a very good efficacy and safety, in the past 5 years, the powder has dropped significantly, becoming a growth hormone dosage form that can be used by short children in China.

Compared with powder, the structure of the water agent is more natural and the quality is relatively higher. Some growth hormone water can be injected with a cryptoneedle electronic pen, which is very helpful in reducing the fear of injection and reducing pain in children's hearts.

Long-acting water is a breakthrough in the research and development technology of growth hormone, which only needs to be injected once a week, giving parents and children a new choice.

Preservatives, also known as bacteriostatic agents, as the name suggests, are substances that can inhibit the growth of bacteria and prevent the growth of bacteria. Chinese name: growth hormone preservative.

Through research, we found that both doctors and patients are more concerned about the safety of a long-term drug. The second is convenience. Then we think safety is more important for patients.

Since the protein is very unstable in aqueous solution, preservatives need to be added to the aqueous agent to inhibit the reproduction of bacteria and prevent protein denaturation. As a kind of preservative, phenol was originally more commonly used, but due to the toxicity of phenol itself, the literature shows that phenol can cause local lipoatrophy and pigmentation, and long-term accumulation in the body will cause neurological damage and liver and kidney function damage, and some patients will also cause damage to reproductive function. Therefore, the state requires that it should be used with caution or as little as possible.

For those that must be used, countries around the world have also set maximum concentrations. Especially for long-term use, countries around the world are also cautious about the use of phenol. Therefore, the use of phenol as a preservative is no longer advocated in the new growth hormone water supplement.

Ansu Meng Water Agent is a new second generation and the only preservative-free growth hormone water agent, which can avoid the damage to the central nervous system, liver and kidney that may be caused by long-term injection of drugs containing preservatives, ensure the safety of children, and be more conducive to long-term use by children. It is the safest growth hormone water in the world.

At present, China's regulations on the use of injection preservatives are not perfect, and it is understood that they are being improved and approved. Only in Appendix IB of the 2010 edition of the Chinese Pharmacopoeia, it is written: "Intravenous infusion and intracisternal, epidural, and intraspinal injections shall not be added with bacteriostatic agents."

Unless otherwise specified, the injection volume of more than 15ml at one time shall not be supplemented with bacteriostatic ......In most cases, it is safe, but some adverse drug reactions are indeed caused by these bacteriostatic agents, so the safety evaluation of bacteriostatic agents in injections should be strengthened, especially in patients with potential allergies. Due to the toxicity of bacteriostatic agents, the lowest effective concentration should be used in the formulation as much as possible. In other words, it is more general.

There are no strict regulations for the use of bacteriostatic agents for injections.

Ansumeng's powder does not contain phenol, because the powder is aseptically produced throughout the process, and the drug is in a solid state, and bacteria are not easy to multiply, so there is no need to add preservatives; And Ansumeng's water agent also does not contain phenol because of the histidine stabilizer used.

The previous aqueous growth hormone agent contained the preservative phenol in order to preserve, and there was neurotoxicity, nephrotoxicity. In 2018, Anke's growth hormone uses the latest technology, no preservatives, and is the safest growth hormone with active EU standards.

Hello, glad you asked, HGH water contains no preservatives. This is because there are active biopharmaceuticals. When storing, it is necessary to inhibit the growth of bacteria and maintain their activity.

Growth hormone generally contains bacteriostatic agents, not preservatives, bacteriostatic agents are to prevent the growth of bacteria after multiple injections of growth hormone after opening, that is, to prevent growth hormone from being contaminated, which is good for children.

Studies on growth hormone have shown that the contamination rate is close to 0 within 4 hours after the injection is configured, and the contamination rate is more than 18% in 7 hours, therefore, the specifications of aseptic operation are: 1. The injection should be prepared and used immediately, and it must be used up within 4 hours; 2. There are safety risks in the use of drugs without bacteriostatic agents for multiple uses, so they cannot be used many times. This means that antimicrobial agents must be added to drugs that have been used multiple times.

Jinsai Pharmaceutical Co., Ltd. adds bacteriostatic agents in strict accordance with national standards to ensure the safety of drugs and the high quality of drug efficacy.

There are no preservatives, but they affect bone health.

Some. Some drug manufacturers have added "phenol" as a preservative to growth hormone, the purpose is to prevent the liquid after opening from being polluted and protein denaturation, "phenol" is also called bacteriostatic agent, the 2015 edition of the Chinese Pharmacopoeia also recommends "adding appropriate bacteriostatic agents" and because drug safety is becoming more and more important, the 2020 edition of the Chinese Pharmacopoeia will also put forward the same rigid requirements for adding bacteriostatic agents to protein drugs as other countries and regions. Long-term use of preservative-containing protein drugs is genotoxic and chromosome breaker that can cause DNA damage, and scientists in the United States have advocated the production of single-dose formulations to avoid the addition of phenol preservatives to biologics. It is understood that there is a growth hormone produced by a manufacturer called Ansu Meng that does not contain phenol!

From a professional point of view, the quality of growth hormone is measured by the "total relevant protein content", and it is not said that it contains preservatives or not, which is like "you eat, others ask you if there are pesticides in your meal" is a very unprofessional question.

First of all: since it is recognized by the state that the growth hormone on the market meets the safety standards, there is no doubt about it! Secondly:

The lower the total protein content, the purer and better the quality of HGH. 30% of the total relevant protein content according to the European Pharmacopoeia (minimum standard); The Chinese Pharmacopoeia stipulates that the total related protein content is 13%; Kinsey Pharmaceutical's internal control standard has a total protein content of 10% (the highest standard), which shows that China's domestic growth hormone is better than that of imported ones. Everyone should also believe in Chinese brands!

Chinese people have always misunderstood preservatives, in fact, the European and American pharmacopoeia emphasized: all multi-dose or multi-use injections must be added with bacteriostatic agents. The 2015 Pharmacopoeia published in China also recommends "adding appropriate bacteriostatic agents".

At present, all domestic and foreign growth hormone aqueous companies have selected phenol or cresol as bacteriostatic agents, and the content is controlled within the limit, which can achieve the goal of both safety and effectiveness, with the aim of reducing bacterial contamination during drug storage and operation. Drug regulatory authorities and medical and health authorities in various countries attach great importance to the safety of children's drug use, and it is impossible to protect the interests of any institution. Usually patients** will choose to use water, which requires long-term injection, and the addition of preservatives is responsible for the patient's health.

Hello, growth hormone is a biologically active drug. It is preservative-free. However, in order to maintain biological activity and antibacterial effects, it will add some additional ingredients.

The preservative in growth hormone is a bacteriostatic agent, which is to ensure that the activity of the protein remains unchanged during long-term storage, and the efficacy remains unchanged. The big guys all know that too many preservatives are not good, and if they can, they don't add them.

Growth hormone is a protein hormone that is a genetic drug. Among them, the protein is active, and the so-called preservative is actually a bacteriostatic agent, which is to ensure that the activity of the protein remains unchanged during long-term storage, and the efficacy remains unchanged. That's why growth hormone is preservatives.

The 2015 edition of the Pharmacopoeia clearly stipulates that bacteriostatic agents must be added to the injection of multiple dose packages to inhibit the growth of microorganisms in the injection. At the same time, the 2010 edition of the United States Pharmacopoeia also stipulates:

Multiple injections of the drug must be supplemented with an antibacterial formula to inhibit microbial growth. Because a single package of growth hormone requires multiple uses, the addition of bacteriostatic agents is the global standard for multiple doses of biologics. Therefore, the type and content of bacteriostatic agents in Sai water enhancer are in line with global and domestic standards, which can inhibit the growth of bacteria while ensuring safety.

The function of preservatives is to inhibit the growth of bacteria, also known as bacteriostatic agents, and is one of the commonly used excipients in food and drugs. The United States Pharmacopoeia, the European Pharmacopoeia, and the Chinese Pharmacopoeia all stipulate that bacteriostatic agents must be added to the injection solution that is used multiple times to ensure that the drug used multiple times is not contaminated. In fact, the foods we use in life, such as milk, biscuits, preserves, etc., all contain bacteriostatic agents, which can be seen in the food ingredients.

Bacteriostatic agents are what keep us safe from injections. Sai supernatant has added "bacteriostatic agent" according to the provisions of the pharmacopoeia, but it is not the concept of "preservative" that is falsely reported on the Internet; Not adding bacteriostatic agents will have a risk of bacterial infection and is unsafe.