What are the common genetic diseases that cause death?

The first category is chromosomal disorders, the second category is monogenic diseases, and the third category is polygenic genetic disorders, common chromosomal diseases, we say Down syndrome.

It is also trisomy 21, which is a relatively common chromosomal disease, which is due to the fact that there are three chromosomes on chromosome 21, so it causes patients to have obvious mental retardation and congenital stupidity. There are also sex-linked sex chromosome disorders, such as Turner syndrome, which is also a sex chromosome abnormality; The second category is monogenic disease, which is a disease caused by a gene mutation, which belongs to a monogenic disease, which can be divided into autosomal dominant inheritance, recessive inheritance and sex-linked dominant inheritance and recessive inheritance. The more common monogenic diseases are like the familiar deafness and albinism.

Phenylketonuria, hemophilia.

and so on, all of which belong to single-gene genetic diseases; The third category is polygenic genetic diseases, polygenic genetic diseases are a type of hereditary diseases caused by two or more gene mutations, which usually have environmental factors that work together to lead to the occurrence of diseases. We are familiar with high blood pressure.

Diabetes, cleft lip and palate, many congenital heart diseases, and neural tube malformations are polygenic genetic diseases.

Many genetic diseases are more serious, and the genetic diseases that cause mortality include congenital heart disease, hemophilia, etc., which are more difficult.

More complex congenital heart disease, such as France, Tetralogy of Luceri and malignant tumors.

There are many more, like phenylketonuria, trisomy 21, sickle cell anemia, and so on.

1.Breast cancer: Breast cancer can be caused by a genetic mutation. BRCA1 and BRCA2 are two well-known genes involved in the inheritance of breast cancer.

2.Ovarian cancer: It is estimated that 10-15% of ovarian cancer samples are caused by mutated BRCA1 or BRCA2 genes.

3.Colorectal cancer: Some colorectal cancers are caused by familial genetic mutations, such as Lynch syndrome and FAP (multiple adenomatosis).

4.Prostate cancer: Familial inheritance of prostate cancer is often associated with the BRCA1 and BRCA2 genes.

5.Hodgkin lymphoma: This cancer can be caused by a genetic mutation. The most common of these is a mutation in the NOD2 gene.

However, it is important to note that even if there is a genetic mutation, it will not necessarily be passed on to the next generation, and even if it is inherited, it will not necessarily develop into cancer.

To put it simply, everything is due to a genetic abnormality.

The diseases caused by them can be called genetic diseases, so the number of genetic diseases is innumerable. Therefore, genetic diseases are generally broadly divided into the following types:

1) Chromosomal genetic diseases: refers to diseases caused by abnormalities at the chromosomal level, that is, diseases caused by abnormalities in number, morphology and structure, such as the familiar trisomy 21. Diseases caused by chromosomal abnormalities are relatively serious, and most of them will cause miscarriage, malformation or premature death.

Therefore, prenatal genetic testing is necessary to decode genes, especially for people who have had multiple miscarriages, malformations, or a family history of chromosomal disorders.

2) Monogenic inherited diseases: refers to diseases caused by abnormalities in 1 pair of alleles. While genes are located on chromosomes, chromosomes are divided into autosomes and sex chromosomes, and genes are also distinguished from dominant genes and recessive genes, so the pathogenic genes located on different chromosomes are inherited in different ways.

Therefore, monogenic diseases can be divided into autosomal dominant diseases, autosomal recessive diseases, X-associated dominant diseases, X-associated recessive diseases, and Y-associated genetic diseases.

The best way to diagnose monogenic genetic diseases is to find the disease-causing gene through genetic testing, and then through genetic decoding and analysis, providing the possibility of effective ** or prevention.

3) Polygenic genetic diseases: As the name suggests, it refers to diseases caused by abnormalities in multiple genes. Its inheritance mode is different from that of single-gene diseases, there is no obvious dominant or recessive distinction, it has an additive effect, and is also affected by environmental factors, such as diabetes, coronary heart disease, hypertension, etc., which are common in life.

Through genetic testing, we can know the causes of these diseases, and genetic decoding analysis based on their pathogenesis can know that we can adjust the medication regimen and supplement effective nutrients, so as to achieve personalized, accurate and effective care for health.

All of them can be detected and analyzed by Jiaxue gene decoding.