What are the clinical manifestations of leukemia and what are the clinical manifestations of leukemi

1.Chronic myeloid leukemia: There are usually no obvious symptoms in the early stages, and most patients are often found during a physical examination or other illness.

At this time, the patient may feel fatigue, emaciation, or low-grade fever, mild anemia, or even bleeding tendency, moderate to extreme enlargement of the spleen, and sternal tenderness is common. It can transform into acute leukemia, when anemia progressively worsens and bleeding increases, the spleen becomes rapidly enlarged and tender, and other symptoms of acute leukemia can be seen.

2.Chronic lymphocytic leukemia: It mostly occurs in middle-aged and elderly people, with a slow onset and mild symptoms, and many patients are found during occasional blood tests.

The common symptom is generalized lymphadenopathy, and some patients have ** infiltrate. Anemia and bleeding often occur later in the disease.

Loss of appetite and weight loss. Easy bruising or bleeding, e.g. bleeding gums, nosebleeds.

It is very susceptible to infections, such as sore throat, bronchitis accompanied by headache, low-grade fever, sore mouth and rash. Swollen lymph nodes, especially in the larynx, armpits and groin. Discomfort under the left flank.

In severe cases, high fever is sudden, consciousness is cloudy, and the inability to speak and move limbs is present.

The first symptom of acute leukemia is usually fever, which can manifest as flaccid fever, lingering fever, intermittent fever or irregular fever, and the body temperature is at or higher. Sometimes cold, but not chilling.

There are no obvious symptoms in the early stages of leukemia, and most patients with vitiligo often find hemorrhoids on physical examination or other Duchenne disease. At this time, patients may feel fatigued, emaciated, or have a low-grade fever, mild anemia, or even a tendency to bleed, and moderate to extreme splenomegaly and sternal tenderness are common. It can be transformed into acute leukemia, when symptoms of acute leukemia such as progressive anemia, worsening bleeding, rapid enlargement of the spleen, and tenderness can be seen.

The increase or decrease of leukemia white blood cells, in addition to the abnormal quantity, also has a qualitative abnormality, that is, the composition of the leukemia changes, and there are a large number of leukemia cells in it, that is, primitive cells, which make it very easy to infect. As a result of the decrease in hemoglobin, the patient develops anemia, which makes the patient prone to fatigue.

Leukemia patients can cause many symptoms such as fever, anemia, bleeding, swollen lymph nodes, and bone pain due to the invasion of various parts of the body by cancer cells.

1. Anemia is often the first symptom of leukemia, mainly manifested as paleness, feeling weak and weak, sweating, shortness of breath and rapid heartbeat both during activity and rest. It gradually worsens over time. The more severe the anemia, the more severe the leukemia 2. Fever More than half of the patients have fever as the early manifestation, which can be a low-grade fever below 38 degrees or a high fever of 39 degrees or even more than 40 degrees.

3. Unexplained swelling Most leukemia patients have superficial lymph node enlargement, which is more common in the submandibular area, neck, supraclaviclavicular bone, armpit and groin, often without obvious pain, and physical examination can find hepatosplenomegaly, and obvious tenderness under the sternum, which is a manifestation of a large number of leukemia cells infiltrating the bone marrow Fourth, bleeding Leukemia has nearly 40% of leukemia with bleeding as the early manifestation. Bleeding can occur in all parts of the body, and is common in unexplained ecchymosis, bleeding from the mouth, nose, and gums, menorrhagia, etc. 5. Headache, nausea, vomiting, hemiplegia, loss of consciousness and other neurological symptoms are due to leukemia's infiltration of brain cells and meninges.

Diagnostic criteria for stolovakia leukemia.

1) Medical history and symptoms

Medical history questions: the onset of the disease is slow, most patients have no obvious symptoms, and the consultation should pay attention to whether there is low-grade fever, night sweats, and easy infection. ⑵

Clinical symptoms: fatigue, emaciation, anorexia, night sweats, decreased physical strength, fever, and occasional itching. (2) Physical examination findings.

Acute granulocyte and monocytic features.

Acute myelocytic and monocytic leukemia (ANUL-M5). Bone marrow or/or peripheral blood with granulocytic and monocytic cells, or blastoblasts with both granulomylotic and monocytic morphological characteristics. If protomyelocyte and promyelocyte proliferation predominate, protomyelocyte and monocyte should exceed 2

Why is a lumbar puncture done for leukemia?

The purposes of lumbar puncture for leukemia patients are: (1) Diagnostic needs.

Cerebrospinal fluid examination is performed by lumbar puncture to identify the patient for central nervous system leukemia. (2)**Yes.

Due to the existence of a natural tissue barrier between the blood vessels and the meninges, the blood-brain barrier, most of the causes.

Chemotherapy is required immediately after the diagnosis of leukemia.

Yes, patients with acute leukaemia should be given aggressive chemotherapy from the date of diagnosis, unless the patient presents with a serious infection (e.g., pneumonia or sepsis) or significant systemic bleeding tendency. Under the premise of active anti-infection, blood transfusion or platelet apheresis, etc., the patient's general condition can be slightly improved.

Features of leukemia in the elderly.

Among the hematopoietic malignant tumors in the elderly, chronic lymphocytic leukemia, malignant lymphoma, and multiple myeloma are the most common, and myeloproliferative diseases including myelofibrosis (MDS), euerythrocytosis, and essential thrombocythemia are also common in the elderly. The incidence of leukemia is relatively high in the elderly.

A drop of blood can diagnose leukemia at an early stage.

A prospective, early diagnosis of MDS and MDS valor can be made with just one drop of blood element. Professor Wang Yongcai, Department of Clinical Laboratory, Second Clinical College of Dalian Medical University, presided over a project "Application Research on Micronucleus Determination and DNA Content Analysis for Early Diagnosis of Myelodysplastic Syndrome (MDS)".

SKY technology contributes to all cytogenetics....

LU et al. reported that spectrokaryotyping (SKY) technology can identify complex chromosomal rearrangements in acute lymphoblastic leukemia (ALL). （leukemia

2002, 16-2222) SKY technique utilizes 24 combinations of labeled chromosome smear probes, with metaphase staining.

Depending on the type of leukemia, there can be many symptoms, such as infection, low or high white blood cells, poor appetite, splenomegaly, anemia, bleeding gums, heavy menstrual bleeding, and leukocytosis.

There were no obvious symptoms in the early stage, but the wound was difficult to heal and the bleeding did not stop. In the later stage, the body has purple spots, black spots, and hair loss. Susceptible to disease.

In the early stage of leukemia, bleeding and fever will occur, and many patients will have anemia.

1. Bleeding. A common symptom in the early stages of leukemia is bleeding, which can occur in various parts of the body. Unexplained ecchymosis usually occurs everywhere, and bleeding from the mouth, nose and gums can also occur, and women may present with menorrhagia. Occasionally, fundus hemorrhages may manifest as blurring of the retina.

2. Fever. More than half of leukemia patients will have fever in the early stage, which can be low-grade fever or high-fever fever, and the patient's body temperature can reach 39 degrees to more than 40 degrees. It is usually accompanied by sweating.

3. Symptoms of anemia.

Most people with leukemia will have early symptoms of anemia, which is mainly manifested by paleness, feeling weak and sweating. Whether active or resting, people experience shortness of breath and a rapid heartbeat, which worsen over time.