Men with chronic nephritis, how to avoid passing it on to children?

You can prepare for pregnancy in advance, check the genetics of nephritis, have regular prenatal checkups during pregnancy, and pay attention to the development of the fetus.

Chronic nephritis is a hereditary disease. Men should have a medical check-up before they become pregnant. Early detection and early intervention are the only way to prevent diseases.

Men should improve their daily routines, increase exercise, and promote metabolism, so that they can avoid passing it on to their children.

Chronic nephritis is not inherited to children. However, if you plan to have children, it is important to control the condition and prevent further deterioration of kidney function.

Many kidney friends are worried that their disease will be passed on to their children, especially after reading some news reports that several families have kidney disease; Or kidney friends chatting with each other, and they always feel very heavy when they talk about this topic.

Doctors will say that most kidney diseases are non-hereditary, except for a few hereditary kidney diseases: thin basement membrane nephropathy, Alport syndrome, hereditary nephrotic syndrome, polycystic kidney disease.

But even so, I'm worried. Why do some of the patients around me have them at home, and he also has them, but the doctor doesn't say it's a genetic disease?

It is very difficult to figure out the complex issue of inheritance. When it comes to genes, scientists with the most advanced modern technology have not been able to understand the full picture of human genes. Sasha, in this article, try to explain this problem to our kidney friends in a language that everyone can understand.

1. Hereditary kidney disease.

Hereditary kidney disease, before the fetus is born, there is a corresponding genetic abnormality, which is what we often call "congenital kidney disease". Over time, the sick child will show signs of related diseases. If the immediate family member has this genetic disease, then the probability of the next generation can be calculated.

If you remember Mendelian's laws of heredity, which we learned in high school biology class, you understand this very well. Suppose that the disease is dominantly inherited, the father carries the gene, which manifests as AA, and the mother does not, and it is AA, then the offspring will be AA, AA, AA, that is, the probability of AA is 50%, and the probability of the child carrying the disease-causing gene is 50%. If the couple has enough children, half of the normal children and half of the abnormal children.

It's okay if you don't understand the above. To sum up: most of these hereditary kidney diseases that we know of have clear disease genes, and these diseases conform to the laws of heredity. If genetic testing is done, most of them can be detected.

and most of the other kidney diseases that we're discussing.

The pathogenesis of this disease is very complex. The disease may be related to multiple genes, multiple genes, so it can be understood that it is not related to each gene alone, but is caused by environmental factors and external triggers. They are intertwined and together determine the occurrence of the disease.

It is also because the vast majority of kidney diseases are very large, so the inheritance of the next generation does not conform to the laws of heredity. The risk for the next generation may be a little higher than others, but not too high (e.g., 20% higher than the normal population).

Just like diseases such as high blood pressure, coronary heart disease, diabetes, asthma, etc., we can find dozens or even hundreds of genes associated with this disease. Each gene contributes a little bit, plus personal lifestyle habits, environment, and many other reasons, which ultimately determine whether or not to get sick.

The next generation will not inherit all genes and may not match all causes of the disease. So it can only be said that the incidence may be a little higher than that of the general population.

To end with one sentence: we don't have children because of high blood pressure, diabetes, coronary heart disease, because basically it is difficult to avoid all diseases, and the incidence of chronic diseases is too high, so many kidney diseases are the same.

Glomerulonephritis can be divided into primary, secondary and hereditary glomerulonephritis, which is a group of kidney diseases with hematuria, proteinuria, edema and hypertension as the main manifestations. Many patients are caused by bacteria, viruses or other pathogens into the body after the body has immune dysfunction, if the immune complex is deposited into the kidneys, resulting in kidney damage, patients often have hematuria, proteinuria, edema, hypertension, if the disease develops further, kidney function damage, blood creatinine increases, and some patients have no obvious clinical manifestations.

To date, there are no drugs that can improve damage to type IV collagen in the basal membrane of tissues in patients with Alport syndrome. For patients with end-stage renal disease in Alport syndrome, one of the most effective measures is to perform a kidney transplant. For patients with Alport syndrome who progress to end-stage renal disease, dialysis or kidney transplantation may be used**.

Kidney transplantation is an effective measure for this disease, but it has been reported that about 3 5% of patients with Alport syndrome who have undergone kidney transplantation produce antibodies to the normal glomerular basement membrane of the transplanted kidney after transplantation, and then develop anti-glomerular basement membrane nephritis, resulting in transplantation failure. In addition, some authors have reported that antiglomerular basement meningonephritis can occur again due to the occurrence of antiglomerular basement membrane nephritis after transplantation and retransplantation in patients who have failed transplantation.

With regard to the choice of donors for kidney transplantation in Alport syndrome, it is generally believed that it is better to choose living donor kidney transplantation, but if anti-basement membrane nephritis after transplantation has occurred, a living kidney should not be used at the end of transplantation. Some studies believe that female carriers of heterozygous col4A5 gene, who have no clinical manifestations of proteinuria, hypertension, renal dysfunction and deafness, can be used as kidney donors, but the probability of renal insufficiency after transplantation will be higher than that of transplanted healthy donor kidneys. Although the mutant genes of various hereditary types of Alport syndrome have been identified in recent years, and certain results have been achieved on the genes of animal models of Alport syndrome, there are still a series of problems in the genes, such as the low transfection efficiency of genes, the introduction route of target genes, the selection of introduction time and timing, the survival time in vivo, the safety of vectors such as viruses and the regulation of target genes after introduction, etc., so the genes of Alport syndrome** It will take time for clinical use.

At present, the cause of nephritis is still controversial in medicine, and it is generally believed that it is due to the human body's immune deficiency and kidney lesions caused by infection, that is, it is related to heredity.

But it is not necessary that parents have nephritis, children will definitely have nephritis. In addition, some mild nephritis does not need to be ** for a lifetime, which has a lot to do with individual differences. However, it is still recommended to pay more attention to diet and control the amount of activity to minimize the burden on the kidneys.

In your case, if there is no improvement after a period of conditioning, the hospital will recommend a kidney biopsy. If you feel that there is no abnormality, you can also skip it, but it is still recommended that you go to the hospital regularly for urinalysis tests.

Condition analysis: Chronic nephritis is not a genetic disease and is generally not hereditary.

Advice: Nephritis in general is not hereditary, only a small amount of nephritis is inherited, such as Alport syndrome, thin basal membrane nephropathy and.

Congenital nephrotic syndrome also has Fabry disease, kidney damage, cystic kidney disease. The proportion in the crowd is smaller.