What causes excessive levels of creatine kinase in the body? What are the effects on the human body?

Overview of metrics.

Creatine kinase, also known as creatine phosphokinase, is present in the cytoplasm and mitochondria and is involved in physiological processes such as intracellular energy transport, muscle contraction, and energy regeneration. Creatine kinase is abundant in skeletal muscle, myocardium and smooth muscle, and is one of the important indicators for the evaluation of myocardial diseases and skeletal muscle diseases.

The magnitude and duration of changes in serum creatine kinase activity are directly proportional to the degree of myocardial tissue necrosis, so creatine kinase activity measurement can be used for the diagnosis of myocardial diseases and skeletal muscle diseases.

Indicator abbreviation: CK

Normal coupling rate method: 50 310u l for males; Females 40 200u l

Creatine chromogenic method: 8 60 u l

The indicator is on the high side. Clinical significance.

Creatine kinase can be elevated due to many causes, such as acute myocardial infarction, viral myocarditis, dermatomyositis, muscular dystrophy, pericarditis, cerebrovascular disease, hypothyroidism and other common diseases. In addition, there are other factors that may cause creatine kinase to increase, such as prolonged strenuous exercise, the use of certain drugs that affect creatine kinase (such as painkillers, antibiotics, etc.), the installation of artificial pacemakers, and radiation**.

Disease ** element. Acute myocardial infarction.

It began to increase at 2 4 hours after the onset of the disease, reached a peak at 12 48 hours, and returned to normal in 2 4 days, and the degree of elevation was greater than that of AST and LDH, and it appeared early, which was basically consistent with the degree of myocardial injury, and the CK activity was also increased in subendocardial myocardial infarction that was not easy to be diagnosed by ECG.

Muscle disorders. Polymyositis, progressive muscular dystrophy, severe muscle trauma and other CK are also significantly elevated.

Brain disorders. Cerebrovascular accident, meningitis, systemic convulsions, shock, tetanus and other CK activities are also elevated.

Other diseases.

Hypothyroidism, certain infectious diseases, malignant hyperthermia, various intubations and surgeries may also increase CK activity.

Clinical significance.

1) After myocardial infarction, CPK is more specific than aspartate aminotransferase and lactate dehydrogenase, but the duration is short, and it returns to normal in 2 to 4 days.

2) In viral myocarditis, CPK can also be elevated, which has reference value for diagnosis and prognosis.

3) CPK can also be elevated in progressive muscular dystrophy, polymyositis and muscle injury.

4) Severe angina, pericarditis, atrial fibrillation, cerebrovascular accident, meningitis and cardiac surgery, etc., CPK can be increased.

Creatine kinase is mainly found in skeletal and cardiac muscles, and physiological elevation can be seen during strenuous exercise, and the longer the time, the more pronounced the increase in creatine kinase. Pathologic elevation can be seen in myocardial infarction, and elevated creatine kinase is a sensitive indicator for diagnosing early myocardial infarction. It can also be seen in myocarditis and muscle disease.

1.After myocardial infarction, CPK is more specific than aspartate aminotransferase and lactate dehydrogenase, but the duration is short, and it returns to normal in 2 to 4 days.

2.In viral myocarditis, CPK can also be elevated, which has reference value for diagnosis and prognosis.

3.CPK may also be elevated in progressive muscular dystrophy, polymyositis, and muscle injury.

4.Severe angina, pericarditis, atrial fibrillation, cerebrovascular accident, meningitis, and cardiac surgery can be seen to increase CPK.

According to the clinical manifestations, the manifestations of elevated creatine kinase can assist in clinical diagnosis and help**. Phosphocreatine kinase is elevated. This enzyme can be elevated when the heart or skeletal muscle is damaged, but you don't have a history or symptoms, and it can be elevated if you exercise vigorously before the exam.

Creatine kinase itself is not harmful to the human body, but some important organs such as heart disease can cause it to rise, indicating that the disease is more serious.

Below 200 μl of normal, creatine kinase is normally present in the heart, and creatine kinase has four isoenzyme forms: muscle, brain, hybrid, and mitochondria. The elevated meaning of different isoenzymes is not exactly the same, it is recommended to go to the hospital for examination, and then **.

Pay attention to rest, eat lightly, and drink plenty of water!

Is it done for the biochemistry of cardiac enzymes, and there should be a normal range on this test sheet, unless it is not done in a regular hospital.

Creatine kinase is too high generally indicates myocarditis, which has a greater impact on the heart, depending on whether it is troponin or myoglobin, or CK MB is high, and the bruises on the legs indicate that there is subcutaneous bleeding, you need to draw blood for a blood test to see if your platelets are too small, if less, it is easy to bleed under the skin, but there may be many reasons You need to do a comprehensive examination to see.

Creatine kinase is usually found in the cytoplasm and mitochondria of the heart, muscle, brain and other tissues of animals, and is an important kinase directly related to intracellular energy operation, muscle contraction, and ATP regeneration. Exercise, infection, muscle damage, and myocardial infarction can all cause an increase in creatine kinase, and the specificity is not high.

Creatine kinase is caused by viral myocarditis, dermatomyositis, muscle injury, muscular dystrophy, pericarditis, cerebrovascular accident and cardiac surgery. However, there are many factors that affect CK, so there is no need to worry too much, and a full set of cardiac enzyme tests can be done.

Creatine kinase (CK) is also known as creatine phosphokinase (Creati).

nephosphokinase，cpk）。Normally, the vast majority of creatine kinases are located in the muscle fines.

Intracellular, elevated creatine kinase in the blood usually indicates pre-existing or ongoing muscle damage.

Chronic elevated creatine kinase is called hypercreatine kinaseemia and occasionally occurs in normal people. In 1980, Rowland referred to the absence of clinical and histopathological evidence of neuromuscular disease as idiopathic hypercreatine kinaseemia.

In patients with hypercreatine kinaseemia with clinical signs of neuromuscular disease, the diagnosis may be confirmed by a variety of tests after presentation.

Asymptomatic hypercreatine kinaseemia is present in patients who meet the following criteria. 1.incidentally elevated serum creatine kinase; 2.

Persistent hypercreatine kinaseemia for at least 3 months; 3.asymptomatic or only mild and non-specific symptoms (incidental episodes of mild myalgia) at presentation; 4.No family history of neuromuscular disease; 5.

lack of clinical manifestations of neuromuscular disease associated with hypercreatine kinaseemia;

6.No cardiac disease (CK MB and normal ECG); 7.There are no other causes of hypercreatine kinemia (malignancy, alcohol and drug abuse, systemic metabolic disorders, infections, malignant hyperthermia, thyroid and parathyroid disorders, hematologic disorders, pregnancy, medications, etc.).

In patients with asymptomatic hypercreatine kinemia, the following tests should generally be performed to determine the cause. 1.Neurological examination, particularly muscle strength testing.

2.Creatine kinase assay in family members. 3.

Blood lactate test: includes basal status, post-forearm ischemia, and post-exercise. 4.

Needle electrode electromyography. 5.Muscle biopsy in which the specimen undergoes routine histology, multiple histochemical staining, immunohistochemical staining for certain antibodies, and electron microscopy.

If the results remain negative after the tests described above, idiopathic hypercreatine kinemias may be considered.

Condition analysis: Hello, for the increase of creatine kinase, it is mainly necessary to consider the opinions and suggestions of muscle diseases: for example, dermatomyositis and other muscle-related diseases, it is mainly necessary to combine the symptoms to make a comprehensive diagnosis.

Is the electrocardiogram normal, is the isoenzyme high, if there is only a high level of creatine kinase, it doesn't mean anything (normal value: 24-195u l), is there excessive activity when drawing blood, it is increased after exercise Muscle damage is also increased Generally within 500 will not have any effect on the human body, pay attention to rest, try to eat less greasy food, have you checked trace elements?

1. Acute myocardial infarction, when acute myocardial infarction occurs, phosphocreatine kinase increases within 3-8 hours of onset, and its peak is 10-36 hours, and it can return to normal in 3-4 days.

2. Seen in myocarditis and myocardial diseases, creatine phosphokinase will be significantly increased in myocarditis, and various muscle diseases, such as polymyositis, rhabdomyolysis, progressive muscular dystrophy, and myasthenia gravis, creatine phosphokinase will also be significantly increased.

3. Myocardial blood reperfusion occurs during thrombolysis in acute myocardial infarction, resulting in a significant increase in phosphocreatine kinase activity, so the activity of phosphocreatine kinase can be inferred from reperfusion after thrombolysis.

4. It can be seen in cardiac surgery or non-cardiac surgery and other injuries, and is closely related to the process of muscle injury, the scope of surgery, surgery, cardioverted heart rate, cardiac catheterization and coronary angioplasty.

In addition, other reasons for high creatine kinase: 1. Various types of muscular dystrophy can increase the activity of CPK, among which the activity of pseudohypertrophic muscular dystrophy enzyme can reach about 10-50 times of normal. 2. Muscle trauma can increase the vitality of CPK.

3. Strong exercise, surgery, and intramuscular injection can also cause an increase in the activity of this enzyme. 4. Cerebrovascular accident, meningitis, hypothyroidism, etc. can also increase CPK activity. 5. CPK activity in acute or rheumatic myocarditis can be up to 5 times of normal.

6. In the case of acute myocardial infarction, the early positive detection rate is high, the specificity is strong, and the increase in enzyme activity is consistent with the severity of the disease.