Vitiligo Forum Network? Vitiligo, forum

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Vitiligo is a relatively common acquired pigmented disease that manifests as a localized or generalized** complete loss of mucosal pigment. It is caused by the loss of melanocyte function, but the mechanism is not clear. It can occur in all parts of the body, and young women are the majority.

1.The doctrine of genetics.

Vitiligo can occur in twins and families, indicating that genetics plays an important role in the pathogenesis of vitiligo. Vitiligo has been suggested to have incomplete penetrance and multiple pathogenic loci in the gene.

2.Autoimmune Theory.

Vitiligo can be combined with autoimmune diseases, such as thyroid disease, diabetes, chronic adrenal insufficiency, pernicious anemia, rheumatoid arthritis, malignant melanoma, etc. Specific antibodies to various organs can also be detected in serum, such as anti-thyroid antibodies, anti-gastric parietal cell antibodies, anti-adrenal antibodies, anti-parathyroid antibodies, anti-smooth muscle antibodies, anti-melanocyte antibodies, etc.

3.Psychiatry and Neurochemistry Doctrine.

Psychiatric factors are closely related to the onset of vitiligo, and most patients have mental trauma, excessive tension, depression or depression at the onset or development stage of the lesion. Degeneration of nerve endings at the vitiligo also supports the theory of neurochemistry.

4.The theory of self-destruction of melanocytes.

People with vitiligo can produce antibodies and T lymphocytes, suggesting that the immune response may cause the destruction of melanocytes. The toxic melanin precursors synthesized by the cells themselves and some chemicals that cause ** decolorization may also have a selective destructive effect on melanocytes.

5.Lack of doctrine of trace elements.

In patients with vitiligo, the level of copper or ceruloplasmin in the blood and ** decreases, resulting in a decrease in tyrosinase activity, which affects the metabolism of melanin.

6.Other factors.

Vitiligo can also be induced by trauma, sun exposure, and some photosensitive drugs.

There is no significant difference in the gender of vitiligo, and it can occur in all age groups, but it is more common in adolescents. The lesions are depigmented patches, often milky white or light pink, with a smooth surface and no rash. The boundaries of the vitiligo are clear, the pigment at the margins is increased compared with normal**, and the hair in the vitiligo is normal or white.

Lesions are more likely to occur in areas of sun exposure and friction injury, and the lesions are mostly symmetrically distributed. Leukoplakia is also often arranged in bands according to the distribution of nerve segments. Vitiligo is often accompanied by other autoimmune diseases, such as diabetes, thyroid disease, adrenal insufficiency, scleroderma, atopic dermatitis, alopecia areata, etc.

Prophylaxis. 1.Reduce the intake of contaminated food, correct picky eating, and formulate scientific dietary recipes.

2.Reduce the inhalation of harmful gases, and choose a place with fresh air during morning exercise or exercise.

3.Pay attention to labor protection.

4.Be aware of the pollution caused by the renovation of the house.

5.Keep a good mood.

Vitiligo has gradually entered our lives, and this disease has left a big shadow on our psyche. Since there is almost no precursor to the onset of vitiligo, which makes many patients unable to prevent it, in order to make our lives more comfortable and reassure our families, we must have a detailed understanding of vitiligo. Let's take a look at the early symptoms of vitiligo.

1. The color of the white spots.

As the condition continues to deteriorate, the color change of vitiligo will go through four processes: light white, cloud white, pure white, and porcelain white. In the early stage of the disease, the white spots are mainly light white, and it is generally difficult for fair-skinned patients to find the changes in their bodies. However, in the early stage of vitiligo, white patches have an obvious feature, that is, the ** around the white patches will be slightly raised, and a dark red circle will also appear on the edges of the white patches.

Except in a very small number of patients whose condition has deteriorated very severely, the symptoms usually last for a few weeks or so. If you find yourself appearing dark red in circles, you need to pay attention to it in time.

2. Number of white spots.

In the early stage of vitiligo, the number of white patches is limited, and the area of white patches does not spread in the early stage of the disease, mainly concentrated in a certain part of the body, and generally concentrates on the nerve segments of the human body. With the deterioration of the condition, the number of vitiligo will gradually increase, and the adjacent vitiligo will begin to fuse, and then connect into a large area of vitiligo. It is very normal for the human body to have spots, but if the spots are white, you need to pay more attention.

3. Hair at the lesions.

Although vitiligo directly affects the color of the hair in the vitiligo area, causing the hair around the vitiligo to turn white, only a very small number of patients with vitiligo develop rapidly in the early stages of vitiligo. Under normal circumstances, because the appearance of vitiligo will directly affect the normal secretion of melanin inside, the pigment band around the vitiligo will become darker, so the area of vitiligo is smaller and lighter in color in the early stage, and there is a clear dividing line between vitiligo. The hair in the damaged area usually does not change in color, but it begins to dry out.

After the vitiligo patient is sick, the doctor usually makes a recipe for the patient according to the patient's eating habits, these recipes are not just made to increase the patient's appetite, these recipes will help the patient's recovery from the disease, as for these recipes, they are mainly for the patient's symptoms to make food improvements, so as to help the patient speed up the recovery.

Vitiligo is an acquired depigmentation disease, which is caused by the loss of melanocyte function and will not affect the patient's life span and all aspects of the body. Although vitiligo does not affect the life expectancy of patients, it can cause other related diseases, such as hair loss, diabetes, thyroiditis, etc., causing damage to the body.

Topical medications. Corticosteroid-containing creams are effective for pigmentation in small lesions. Can be applied in conjunction with other methods.

Hormones can cause atrophy and even form stretch marks in specific areas and should be used under the guidance of a doctor. At present, the calcineurin inhibitor tacrolimus has achieved good results in vitiligo, and there is no long-term external use of hormones, which is worth trying.

Phototherapy. At present, there are 308nm excimer laser, narrow-wave UVB and other lasers and phototherapy instruments that can be used for vitiligo. Puva - The use of a photosensitizer psoralen can promote pigment production, after taking psoralen** very sensitive to light, and then irradiated with special ultraviolet UVA**, this method requires special equipment.

If the lesion is localized, topical psoralen may be used. Psoralen is usually taken by mouth. The use of puva** has a 50-70% chance of restoring color to the proximal end of the face, trunk and limbs.

Poor hand and foot reactions. **Cycle for at least one year, twice a week. Puva** must be supervised and monitored by a doctor.

Its side effects are similar to sunburn, and long-term application will cause freckle-like spots to form and increase the incidence of ** tumors. Psoralen also increases the sensitivity of the eyes to light, so patients need to wear UVA lenses throughout the day to prevent cataracts. PUVA is generally not used in children under 12 years of age, pregnant and lactating women, and patients with certain medical conditions.

Autologous epidermal transplantation.

Transplantation of normal** to the site of vitiligo is suitable for patients with relatively small skin lesions in the stable stage of the disease. The pigment at the transplant site may not always be fully restored.

Masking method. Using covering cosmetics, dyes, and self-tanning compounds is a simple and safe way to do so. Sun-faux compounds such as dihydroxyacetone can give ** a wheat-like color after sunning.

None of these masking agents are permanent and do not alter the course of the disease, but they are satisfactory for the improvement in appearance. If the effect of sunscreen and concealer is not ideal, for patients with severe conditions, some decolorizing drugs can be used to remove the normal residual pigment and make the whole body appear a uniform color. [

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