How does genetic testing play a role in precision medicine?

Genetic testing guides precision medicationIt is to interpret the genetic code related to drug response, and the degree of adverse reactions of patients to different drugs plays a certain guiding role in clinical use.

At present, clinicians follow the best guidelines in principle, but the guidelines are aimed at groups, and the individual differences in the human body are very large. <>

Referring to the results of genetic testing, doctors can propose individualized medication plans suitable for each patient in terms of drug selection, dose control and combination of drugs when prescribing, so as to improve drug efficacy, reduce drug toxicity and reduce medical costs. Let patients spend the shortest time, the least money, to achieve the best results.

For example, many people with cardiovascular and cerebrovascular diseases take an anticoagulant called warfarin. According to the instructions, it is enough to take 3 mg at a time, but some people eat it just right, some people will bleed heavily if they eat half ......a tablet, and some people will not work if they take two or three tabletsExactly how should the medication be used. <>

This is because each person has different genetics, gender, height and weight, different environment, different lifestyle, etc., which leads to differences in efficacy.

Through genetic testing and comprehensive analysis of acquired factors, precision medicine has formulated a first-class drug program, which on the one hand reduces the first-class drug and its corresponding toxicity, and on the other hand, it can also save medical costs.

Aspirin can prevent cardiovascular disease, but only half of 100 people may benefit, others may not benefit significantly, and even cause stomach bleeding, cerebral hemorrhage, etc. <>

However, individualization can lead to a better outcome for the 50% who do not benefit from the drug to switch to other drugs.

Using advanced molecular biology technology to detect and interpret drug-related genes of different individuals, clinicians can implement dosing regimens according to the patient's genotype data to improve the efficacy of the drug and reduce the toxicity and side effects of the drug, while reducing the pain and economic burden of the patient. <>

First of all, according to the instructions, it is okay to take one tablet of 3 mg at a time, but some people eat it just right, some people will bleed heavily if they eat half ......a tablet, and some people will not work if they take two or three tabletsIn the end, how to use medicine, the correct way is individualized medicine under the guidance of precision medicine. Genetic testing is carried out on the patient, and the patient's height and weight are calculated at the same time, so as to select the appropriate drug and the appropriate dosage for the patient. Integrative drugs** will be the way forward.

Furthermore, adverse reactions: due to individual genetic differences, different people will have different reactions to foreign substances (such as drugs), so some patients may have drug allergies, redness, swelling and rashes when using normal doses of drugs, or when taking the same drugs, some people feel that the effect is very good, but some people are not only ineffective but also toxic. It plays a certain guiding role in clinical use. <>

Referring to the results of genetic testing, doctors can put forward individualized medication plans suitable for each patient in terms of drug selection, dose control and combination of drugs when prescribing, so as to improve the efficacy of drugs and reduce drug toxicity, so that patients can get out of the blind spot of medication, use quasi-drugs, use good drugs, and grasp the best period. <>

Before taking the drug, the effect of genetic testing is more accurate, the effective drug is correctly selected, the drug waste and drugs are avoided, and the first plan of drug is formulated after the comprehensive analysis of genetic testing and acquired factors, which reduces the drug and its corresponding toxicity on the one hand, and can also save medical costs on the other hand, so as to achieve better results.

We have found that when certain drugs are applied to different people, the effects are different from ***.

In the past, for different patients with the same disease, they were simply divided into subtypes mainly through blood and imaging examinations, and the patients were given standard doses of the same drugs, without considering the effect of the drugs and the impact on different individuals, which meant that to some extent, patients had to "try the drug".

With the development of genomics, we know more and more about the truth of individual differences, and scientists continue to confirm which genes and which loci determine the efficacy and size of a drug after entering the human body.

The metabolic rate and enzymatic reaction rate of each person to the same class of drugs are different, and the dosage and dosage of drugs seen in the common drug instructions are the average data obtained during clinical trials based on the normal metabolic rate of most populations, but there are obvious differences in individual responses to drugs, and these differences are based on the genetic differences that encode related functional proteins in vivo.

Through genetic testing, individuals can know their own sensitivity to various drugs and medication recommendations, which can guide the clinical ** to directly choose the most suitable drug for patients between different drugs.

Especially in cancer, targeted drugs are based on the gene sequencing of tumor patients, targeting specific molecules in tumor cells to block or affect their functions, so as to inhibit tumor invasion or metastasis.

In other words, scientists first identify which gene or gene mutations cause cancer to occur or metastasize, and then design and develop drugs for this gene mutation. Generally, such drugs are not universal, but they have good efficacy and few drugs for the group they are suitable for, which greatly reduces the pain of patients and improves the success rate.

Da'an Gene Children's Safe Drug Genetic Testing, which can accurately detect the baby's drugs must be banned, and those drugs should be used with caution, pointing out the specific requirements for medication at different ages, and completely avoiding the harm caused to the baby by improper medication.

Chemically guided genetic testing is to analyze the absorption, transport, metabolism and toxic reactions to the nervous system, kidneys, liver and other organs that affect the drug, and compare the effect after using the drug, so as to determine the pros and cons of using the drug.

Genetic testing is the technology of DNA detection through body fluids or cells, taking the peripheral venous blood or other tissue cells of the tested person, expanding its genetic information, and testing the DNA molecular information in the cells of the tested person through specific equipment, analyzing the gene type and gene defects it contains and whether its expression function is normal, so that people can understand their own genetic information, and clearly or predict the risk of a certain disease in the body.

Detection method. There are generally three methods of genetic testing: biochemical testing, chromosomal analysis, and DNA analysis.

Genetic testing can be divided into the following five categories:

1) Genetic screening.

Testing is mainly for specific groups or the entire population. Prenatal or neonatal genetic testing for screening purposes.

2) Reproductive genetic testing.

It can be used during the IVF stage to screen out whether the embryo has a genetic mutation and avoid hereditary diseases.

3) Diagnostic testing.

Most are used to assist in clinical medication guidance.

4) Gene carrier testing.

If the gene carrier is combined with some special genes, it can be used as a reference for the gene carrier for premarital examination and childbirth.

5) Testing before symptom onset.

The purpose of the test is to see if people who are currently healthy have a mutated gene.

It mainly depends on the design project. The medication guidance of Jiaxue Gene is designed to be admired by Xiaoke. First, look at the neurotoxicity, liver toxicity, kidney toxicity and so on of a drug in different people; Second, look at the metabolism of the same drug in the body, so as to analyze and evaluate the effective dose of the drug, and adjust the dose for different people.

Jiaxue Gene is even more unique in proposing the unique efficacy of some small molecule drugs. This is very high-tech, but it also requires a lot of knowledge from doctors.

For doctors, chemical drug genetic testing can predict the efficacy and toxicity of drugs before medication, increase the effectiveness of the first dose prescription, and optimize the drug dose after medication; For patients, it can shorten the course of the disease, reduce medication and hospital stay. Reduce misdiagnosis and alleviate doctor-patient disputes.

Chemical medication-guided genetic testing is to analyze the strength of the human body's drug absorption, metabolism and other functions by means of genetic testing, evaluate the effect and toxicity risk after medication, scientifically guide personalized medication, and avoid the physiological and economic double burden of step-by-step drug testing.

Genetic testing is the technology of DNA detection through body fluids or cells, taking the peripheral venous blood or other tissue cells of the tested person, expanding its genetic information, and testing the DNA molecular information in the cells of the tested person through specific equipment, analyzing the gene type and gene defects it contains and whether its expression function is normal, so that people can understand their own genetic information, and clearly or predict the risk of a certain disease in the body. There are generally three types of genetic testing: biochemical testing, chromosomal analysis, and DNA analysis.

The clinical application of downstream gene sequencing approved by the State Food and Drug Administration of China is divided into four categories, namely genetic disease diagnosis, prenatal screening and diagnosis, preimplantation embryo genetic diagnosis, and tumor diagnosis and **.

If you want to know more about genetic testing, we recommend consulting Hypros. Hypros is a national high-tech enterprise for tumor liquid biopsy and gene big data, and its Haicode Gene "Zhixin'an" is a medical-grade personal genetic testing product for hereditary cardiovascular diseases. Based on next-gereration sequencing (NGS), the whole exome region of more than 22,000 genes in the human genome is detected to help you predict the risk of congenital cardiovascular genetic diseases and prevent them accurately.

Is it necessary to do genetic testing if I am not sick? People have something to say.

Genetic testing for medication has two main functions.

1) Determine the existence of the target: Some tumor targeted drugs have target selectivity, and the positive expression of the target must be determined before molecular targeted drugs can be used.

2) Confirm the type of metabolism, there are obvious individual differences in the expression of CYP450 in the human body, and the metabolism speed and mode of the same drug in different human bodies are very different (isoniazid is divided into fast metabolism (liver damage) and slow metabolism (neuritis)), and the metabolic mode is determined by genetic testing to adjust the dosage and prevent adverse reactions.

Genetic testing is a technology that detects DNA through blood, other body fluids or cells, which is to take the oral mucosal cells or other tissue cells shed by the tested person, expand their genetic information, and detect the DNA molecular information in the cells of the tested person through specific equipment, predict the risk of disease in the body, and analyze the various genes it contains, so that people can understand their own genetic information, so as to avoid or delay the occurrence of diseases by improving their living environment and living habits.

Genetic testing can be used to diagnose diseases and can also be used to determine the risk of disease**. Disease diagnosis is the use of genetic testing technology to detect mutated genes that cause hereditary diseases. At present, the most widely used genetic testing is the detection of neonatal hereditary diseases, the diagnosis of genetic diseases and the auxiliary diagnosis of some common diseases.

There are currently more than 1,000 genetic diseases that can be diagnosed by genetic testing.

**Genetic testing is the use of genetic testing technology to detect the risk of disease before it occurs, and to prevent it early or take effective interventions. There are already more than 20 diseases that can be treated with genetic testing**.

In the test, the person's genes are extracted from the blood or other cells. Then, primers and PCR technology that can identify genes that may have mutations are used to replicate these genes many times, and mutant gene probe methods, enzyme digestion methods, gene sequence detection methods, etc. with special markers are used to determine whether there are mutations or sensitive genotypes in these genes.

More than a dozen common cancers, as well as nearly 100 common diseases such as depression, diabetes, and Alzheimer's disease, can be tested through genetic testing to understand the risk of disease and carry out targeted prevention.

What is the use of testing, and can doctors restore the genes to normal genes?

Can the patient die clearly? If you don't change your physique, which is prone to tumors, everything will be in vain.

Whether the crops grow well or not depends on the quality of the soil;

Whether the fish grow well depends on the quality of the water;

Whether a person's body is good or not depends on his physique.

Cold, damp, poisonous, and "poisonous" tumors grow in a hypoxic environment.

Because genes are the essence of these diseases, genetic testing can be used to check for diseases.

Accurately and effectively find the cause of the disease, so as to achieve early detection, early intervention, and early **.

You can find out the disease in a timely manner**.

The more powerful the gene bank, the more powerful it will be for big data analysis.

Find the first, intervene in time, and the drug can be targeted.

It provides a means to diagnose diseases and is more efficient.