What is the difference between an attenuated vaccine and an inactivated vaccine?

1. The state of pathogenic microorganisms is different.

Inactivated vaccines are vaccines made by inactivating pathogenic microorganisms (including bacteria, viruses and rickettsia, etc.) and their metabolites by physical or chemical methods, losing their virulence, but still retaining their immunogenicity; Live attenuated vaccines are made by making pathogenic microorganisms (bacteria and viruses) under artificial conditions to make them lose their pathogenicity, but still retain their reproductive ability and immunogenicity.

2. The action time in the human body is different.

Inactivated vaccines generally produce low immunity after one injection, and need to be injected 2 or 3 times or booster injections to produce more satisfactory immunity; Live attenuated vaccines have a long time in the body and often only need to be vaccinated once to produce solid immunity, such as polio vaccine and measles vaccine.

3. Security is different.

The inactivated vaccine is safe to use, easy to store, and free of contamination hazards; Generally, live attenuated vaccines retain a certain residual virulence, which may induce serious diseases in some individuals (such as immunodeficient patients), and live attenuated vaccines are live microbial preparations, which may cause environmental pollution and cross-infection.

1. Preparation principle:Inactivated vaccine is a vaccine made by killing pathogenic microorganisms, which lose their infectivity and pathogenicity, only retain immunogenicity, and are safe to use; Live attenuated vaccine is obtained by using the natural attenuated strain of pathogenic microorganisms or attenuated treatment by culture and passage, etc., pathogenic microorganisms have immunogenicity and weak pathogenicity, but may be imperfect attenuation, residual virulence rises, and is potentially dangerous to the human body.

Inactivated vaccines have a short immunization period; Live attenuated vaccines have a longer immunization period.

3. Immunization program:Inactivated vaccines are usually given in large doses and require multiple doses; Live-attenuated vaccines are usually given at smaller doses. Common inactivated vaccines include rabies vaccine, inactivated polio vaccine, influenza vaccine, epidemic hemorrhagic fever vaccine, etc.; Common live attenuated vaccines include measles-mumps combined live attenuated vaccine, live attenuated varicella vaccine, etc.

Different types of vaccines have their own advantages and disadvantages, and you can get the appropriate vaccine according to your own situation under the guidance of a professional doctor.

1. The state of pathogenic microorganisms is different.

Inactivated vaccines are vaccines made by inactivating pathogenic microorganisms (including bacteria, viruses and rickettsia, etc.) and their metabolites by physical or chemical methods, losing their virulence, but still retaining their immunogenicity; Live attenuated vaccines are made by making pathogenic microorganisms (bacteria and viruses) under artificial conditions to make them lose their pathogenicity, but still retain their reproductive ability and immunogenicity.

2. The action time of cherry barrage in the human body is different.

Inactivated vaccines generally produce low immunity after one injection, and need to be injected 2 or 3 times or booster injections to produce more satisfactory immunity; Live attenuated vaccines have a long time in the body and often only need to be vaccinated once to produce solid immunity, such as polio vaccine and measles vaccine.

3. Security is different.

The inactivated vaccine is safe to use, easy to store, and free of contamination hazards; Generally, live attenuated vaccines retain a certain residual virulence of spinal hu, which may induce serious disease in some individuals (such as immunodeficient patients), and live attenuated vaccines are live microbial preparations, which may cause environmental pollution and cross-infection.