What causes cerebellar ataxia?

Inherited genetic defects: due to abnormalities in the genes on the chromosomes, polyglutamine is produced, and polyglutamine has a neurotoxic effect that affects the normal function of cells and thus induces ataxia. This inheritance is autosomal dominant, which means that if one parent has the disease, the child may have the disease; Some are autochromed recessive, meaning that neither parent has the disease, but children may also have the disease.

Cerebral palsy: Cerebral palsy caused by congenital developmental problems can cause damage to a child's brain before, during, or after birth, which in turn impairs the child's ability to coordinate body movements, leading to ataxia.

Acquired ataxia.

Head trauma: When the head is traumatized, such as mechanical injury, smash injury, impact injury, etc., the impact on the head can damage the brain or spinal cord, causing damage to the nerve cells of the cerebellum that control muscle movement, or causing peripheral nerve damage between the spinal cord, cerebellum and muscles, thus causing acute ataxia.

Interruption of blood flow: When a part of the blood in the brain is suddenly interrupted or severely reduced, such as cerebral thrombosis, severe cerebral vascular stenosis, etc., the brain tissue will lack oxygen and nutrients, which may cause brain cell death and induce ataxia.

Autoimmune diseases: A variety of autoimmune diseases, such as multiple sclerosis, sarcoidosis, celiac disease, etc., can impair the ability of the cerebellum to control muscle coordination, leading to ataxia.

Viral infections [2]: Viral infections such as chickenpox, caused by varicella-zoster virus, can cause complications of ataxia. Ataxia may occur during the healing phase of the viral infection and persist for a certain period of time.

But in most cases, the ataxia caused by viral infections slowly resolves over time.

Paraneoplastic syndromes: When a patient has a malignant tumor such as lung, ovarian, breast, or lymphoma, the body's immune system responds to the tumor, thus inducing ataxia. Ataxia in this condition may develop before the cancer is diagnosed.

Brain or cerebellar lesions: such as brain tumors, cerebellar tumors, cerebellar abscesses, cerebellar deformities and atrophy, etc. As the tumor in the brain grows, it may invade the cerebellum or compress the cerebellum, causing damage to the cerebellar nerves and causing ataxia.

Cerebellar tumors and cerebellar atrophy can cause damage to cerebellar nerve cells, which in turn causes ataxia.

Medications: Some medications, such as barbiturates such as phenobarbitals and sedatives such as benzodiazepines, may affect the coordination of cerebellar control muscles. However, these medications can often be restored after the dose is reduced and the medication is stopped.

Poisoning: Alcoholism, drug poisoning, heavy metal poisoning (such as lead, mercury), paint thinner, etc., will paralyze and damage the cerebellar nerves, and then cause ataxia.

Cerebellar ataxia is a common neurological disorder caused by a variety of bacterial infections, such as diphtheria, whooping cough, scarlet fever, etc., and is an extremely rare disease. Viral meningococci, influenza bacilli, mycoplasma, etc. can also cause symptoms of acute cerebellar ataxia. Drug poisoning, especially ataxia due to phenytoin overdose.

Cerebellar dysfunction can be caused by enterovirus, echovirus, coxsackievirus, poliovirus, or measles, rubella, mumps, Epstein-Barr virus, influenza virus, adenovirus, herpes simplex virus, etc., and there is no familial genetic tendency.

Injury, degeneration, and loss of function of the nerve tissue that controls muscle coordination can lead to ataxia.

Problems with the connections between nervous tissues such as the cerebellum and spinal cord and muscles can also lead to ataxia.

Disease analysis: The most common causes of cerebellar ataxia are, cerebral hemorrhage, cerebral infarction, cerebral flow, etc., cranial nerve damage caused by a variety of reasons, resulting in coordination disorders, and balance disorders, such as unsteady standing, unsteady walking, and staggering gait.

Ataxia is the most common clinical symptom of cerebellar injury. Cerebellar injury caused by any cause will lead to ataxia, which can be mild or severe, and the common causes are cerebrovascular disease, inflammation, tumors, trauma, etc.

The occurrence of first cerebrovascular diseases is generally caused by traumatic brain injury and brain tumors;

In the second year of aging, the functions of the human body decline and the immunity decreases, leading to the occurrence of diseases;

third, vitamin deficiency can easily lead to ataxia;

Fourth, bacteria cause ataxia, and many diseases of the human body can infect nerves, all of which can cause cerebellar dysfunction and cause ataxia.

Ataxia due to cerebellar atrophy is characterized by cerebellar atrophy and is a disease of the nervous system with a slow and progressive onset that may not be noticeable in the early stages of older patients. However, if it is a young patient, there may be dizziness, nausea and vomiting in the early stage of cerebral atrophy, and with the aggravation of cerebral atrophy, the symptoms of dizziness are more serious, accompanied by nausea and vomiting, and even unsteady walking, swaying from side to side, unable to pick up vegetables when eating, or unable to accurately put food into the mouth, and some patients will choke on drinking water and eating, and cerebellar language and typical plosive sounds will appear in the later stage. Bed rest is required.

Cerebellar ataxia is a disorder of voluntary movements caused by various lesions in the cerebellum. The cause of cerebellar ataxia is closely related to genetic factors, and cerebellar ataxia caused by genetic factors is a primary ataxia. In addition, there are provocative cerebellar ataxia caused by various diseases, and the common causes of secondary cerebellar ataxia mainly include various infectious diseases occurring in the cerebellum, alcoholism, vascular lesions, metabolic diseases, primary or metastatic tumors, multiple sclerosis and other diseases.

There are many reasons for this, natural aging, trauma, inflammation, tumors, etc. can cause cerebellar function to atrophy and ataxia.

Cerebellar ataxia is a relatively rare disease, although today's ** has made good achievements, but its comprehensive ** difficulty is still very large, and its condition is more complex, and the overall impact on the human body is very large, so if you want to complete it more targeted, you must understand its synthesis**, only in this way can you guarantee the effect of **.

Cerebellar ataxia can be divided into secondary cerebellar ataxia and primary cerebellar ataxia. Among them, hereditary ataxia is mainly caused by chromosomal dominant inheritance, which is generally closely related to genetic changes, so the incidence of this disease in the family will be greatly increased. Therefore, if the family has a history of related genetic diseases, special attention should be paid to pregnancy and follow-up examinations, and it is necessary to test from the degree of genetic health to ensure that family planning is done under the premise of genetic health, and only by ensuring the development of eugenics can the genetic generation of cerebellar ataxia be avoided as much as possible.

There are many causes of secondary cerebellar dyssupply, generally speaking, it is a complication of many diseases, such as infectious diseases, malignant tumors, cardiovascular diseases, metabolic diseases of the human body and other common diseases of the human body will be an important part of its onset**, and various changes in the state of the body may also lead to the onset of secondary cerebellar dyssupply. Therefore, after any abnormalities in the human body, we must seek medical attention in time, deeply understand the condition of the body, find out the positive**, and avoid the common harm of a variety of complications.

Nowadays, there are still many measures for cerebellar ataxia, but the use of hormones will have a certain amount, so we must seek a better way according to the patient's balance and coordination.

CT has been doneMRI, electroencephalogram, and routine tests are all confirmed by the doctor to be normal, and other tests are not necessary.

The age of onset can be between 20 and 30 years old or 50 years old, and patients show poor limb balance, unstable gait, and some patients cannot walk and need to be wheelchair-proof. In addition, carbon monoxide poisoning can also cause cerebellar atrophy; Traumatic cerebellar atrophy is also common; Drug poisoning can also cause cerebellar atrophy.

Cerebellar ataxia can be divided into: secondary cerebellar ataxia and hereditary cerebellar ataxia.

Secondary cerebellar ataxia: non-hereditary causes. These include idiopathic cerebellar ataxia and acquired ataxia with a well-defined** setback.

Acquired ataxia** includes paraneoplastic syndromes due to infection, ethanol toxicity, vitamin deficiencies, multiple metabolic disorders, mitochondrial encephalomyopathy, multiple sclerosis, vascular disease, prion disease, primary or metastatic tumor, ovarian, breast, or lung occult malignancy.

Hereditary cerebellar ataxia: It is divided into three types: autosomal dominant ataxia, autosomal recessive cerebellar ataxia and X-linked cerebellar ataxia. It is mainly related to genetics.

Symptomatic manifestations of cerebellar atrophy ataxia at various stages:

Initial symptoms:

1. Walking is like getting drunk (dizziness).

2. The action response is less flexible, and it is difficult to lift heavy objects.

3. The legs are uncoordinated when going up and down the stairs, the muscles are stiff, and some specific actions cannot be completed accurately, such as running, climbing, playing ball, etc.

4. When standing still, the body will shake back and forth, and it is easy to splash out when carrying water. It is easy to bump into walls or door frames when walking.

5. There is an obstacle in eye movement, and the target cannot be quickly transferred.

6. Poor ability to distinguish distance, such as not being able to play table tennis.

Interim symptom presentation:

1. The sense of incoordination of limbs and muscles is aggravated, and the phenomenon of movement disorder is obvious.

2. Unable to control posture and pace, like a penguin walking; Wobbly, legs slightly spread or scissor step, inability to maintain balance, inability to walk long distances, inability to run, difficulty going up and down stairs, inability to adjust the body flexibly when walking. Therefore, it is easy to fall.

3. Knotted tongue, unclear speech, difficulty in writing, easy to choke when eating or drinking.

Late symptom presentation:

1. Speech is extremely unclear, unable to control the pitch, even unable to speak, indecipherable writing, and difficulty swallowing.

2. Unable to stand, or even sit up, need to rely on a wheelchair to walk, or stay in bed, unable to take care of themselves.

3. If the brain or peripheral nerves are affected, the patient's intelligence will be affected.

Cerebellar ataxia is caused by lesions of the cerebellum and its associated neurostructures: truncal ataxia, truncal ataxia (postural cerebellar ataxia), which is characterized by impaired gait and posture (standing and sitting) balance, such as unsteady standing, sedia-up, unsteady walking, positive Romberg sign (eyes open, closed), upper extremity ataxia is unknown and obvious, and nystagmus is often absent. The diagnosis is based on damage to the cerebellar vermis (primitive cerebellum).

It can be seen in ADCA type, ataxia, telangiectasia, etc. Limb coordination ataxia, limb coordination ataxia (motor cerebellar ataxia), mainly manifested as the patient's limb balance disorder to complete various movements, such as finger-nose test, heel knee and shin test inaccurate, poor distance discrimination, poor alternating movements, misfinger test bias to the affected side, nystagmus is more common (coarse), gait instability, etc. Ataxia is generally more severe in the upper limbs than in the lower limbs.

The localization diagnosis is based on damage to the cerebellar hemispheres (neocerebellum).

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Cerebellar ataxia is a syndrome characterized by cerebellar dysfunction due to a variety of causes. When infection, poisoning, brain tumors and other conditions occur, cerebellar ataxia can be caused, and infectious diseases are more common. In general, patients with cerebellar ataxia are mainly manifested by unsteady walking, limb tremor, slurred speech, abnormal posture, inability to complete fine motor skills, low muscle tone, clumsy movements, and difficulty in writing.

On **, if it is caused by infection, the main anti-infection ** is adopted. If it is tremor, it can be treated symptomatically with drugs. The disease lacks a specific effect**, and drugs such as idebenone and butylphthalide can be used to reduce symptoms.

It can also be used with traditional Chinese medicine for syndrome differentiation and treatment, and the effect is relatively good. **It is mainly to nourish the kidneys and strengthen the brain, nourish the blood and dispel wind. It can also be combined with acupuncture massage.

Cerebellar ataxia is a common neurological disorder caused by a variety of bacterial infections, such as diphtheria and whooping cough.

Scarlet fever. etc., is an extremely rare disease. Viral meningitis.

Diplococcus, influenza bacilli, mycoplasma, etc. can also cause symptoms of acute cerebellar ataxia. Drug poisoning, especially ataxia due to phenytoin overdose. Small enterovirus, echo virus, coxsackievirus, polio virus, or measles.

Rubella. Mumps, Epstein-Barr virus, influenza virus, adenovirus, herpes simplex virus, etc., can cause cerebellar dysfunction without familial genetic tendency.