Are there any side effects of long term use of Heptin?

Lamivudine (Heptin) and Tilmivudine are nucleoside antiviral drugs, which are mainly manifested in the following points: (1) 10 patients have transient increases in amylase and lipase after taking it, and may cause damage to other organs and tissues such as liver. (2) During the high replication period of hepatitis B virus, serum alanine aminotransferase can be increased several times, so it is necessary to take traditional Chinese medicine Sunflower Liver Protection Tablets to assist **, which can not only synergistically lower enzymes, but also promote liver cell repair and regeneration, and inhibit liver fibrosis.

3) Long-term use, generally more than 6 months of patients, may appear HBV virus DNA polymerase mutations. (4) A small number of patients will have allergic reactions, drug discontinuation** and liver failure, paronychia, lipometabolism disorders, and hemophilia bleeding after taking lamivudine and telbivudine.

Of course, there will be allergic reactions, discontinuation of medication** and liver failure, paronychia, lipodystrophy, causing hemophilia bleeding.

Any drug has ***, and occasionally there are adverse reactions, which should be explained in the instructions. Among the many antiviral drugs, it is the first to go on the market, and it has been used for 11 years now, I think a product can be used for 11 years, and it is currently the most widely used, it must have its uniqueness, which includes good efficacy, rapid virus reduction, cheap, and safety. So I think since I have chosen, I should stick to it for a long time.

Antiviral fighting is a long-term battle, and it is better not to use drugs if you don't insist on using them. In addition, it does have a certain percentage of virus mutations, which is also common to all antiviral drugs, as long as it is combined with Shanghe Weili, it is completely fine. If you have any questions, you can still contact me.

Including wanting to buy this product.

According to the case report database data of the National Adverse Drug Reaction Monitoring Center, lamivudine may cause damage to the musculoskeletal system, and the prognosis of myalgia and increased creatine kinase is good, but if not treated in time, it may develop rhabdomyolysis. Timely detection of rhabdomyolysis associated with lamivudine and telbivudine is important and should be of concern to clinicians and patients.

**During this period, the patient's clinical condition and virological indicators should be checked regularly. A small number of patients may get worse after stopping using this product. Therefore, if this product is discontinued, the patient should be closely observed, and if the hepatitis worsens, the product should be considered again**.

This product is not recommended for patients with creatinine clearance < 30 ml min. This product cannot prevent patients from infecting others with hepatitis B virus through sexual contact or blood-borne transmission, so appropriate protective measures should still be taken.

The virus will mutate if you take it for a long time.

Precautions for the use of Heptin (lamivudine tablets):

1 Those who are allergic to this product are prohibited;

2 For patients with creatinine clearance of < 30ml min, this product is not recommended;

3 Generally should not be used during pregnancy;

4. When used simultaneously with drugs with the same excretion mechanism (such as trimethoprim), the blood concentration of this product can be increased by 40%, which is not clinically significant, but patients with renal impairment should pay attention;

5 There are no efficacy and safety data in patients under 16 years of age;

6 After the drug is stopped, it is easy to rebound, so during the withdrawal period, the serum ALT should be rechecked every month, if it is normal, it should be tested for HBEAG or HBV DNA once every 3 months, and if it turns from negative to positive, it must start a new round **.

Hepding's biggest problem is drug resistance! Once drug resistance occurs, it will have a huge impact on the future! Not much else!

Hello! 1. If the hepatitis B virus is in a high level of replication, it is necessary to take antiviral**, take Heptin, 1 tablet the next day, at least 1 year, and test B ultrasound, liver function and HBV-DNA once every three months or six months, if the virus stops replication, the aminotransferase will recover naturally;

2. If the hepatitis B virus no longer replicates, the dose of Heptin should be reduced, but the drug should not be stopped immediately to prevent hepatitis B virus**, and the dose of Heptin can be stopped until the dose is reduced to the minimum amount;

3. If the liver function test is normal, the HBV-DNA test is negative, and there is antiviral** for more than one year, you can gradually stop antiviral**, and coexist peacefully with hepatitis B virus, from the beginning of the drug to the discontinuation of the drug, it will take about 1 2 years to completely stop. There is a very high probability that the hepatitis B virus will no longer be able to do so.

First of all, it is rare for Heptin to want to take a single drug for a lifetime, because it is too easy to resist drugs! Oral antiviral drugs are all drug resistant, and they generally need to be taken for a long time, but they can be stopped after the discontinuation criteria: the drug can be stopped after one year of stability after the big three yang turns to the small three yang, but there are still some patients who have nothing **.

If you are young, it is recommended to use interferon. If you want to inquire further, you can ask us.

In the limited data on acute drug overdose in humans, no deaths occurred, and all patients were a**. No specific signs and symptoms were seen after the overdose. Although there are no studies on this, if an overdose occurs, patients should be monitored and given routine supportive care as required**.

Because lamivudine can be cleared by dialysis, continuous hemodialysis can be used when an overdose occurs and clinical signs or symptoms appear**.